Interaction of Visual and Oculomotor Signals in Cortex

皮层视觉和动眼神经信号的相互作用

基本信息

批准号：
10667437
负责人：
TIRIN MOORE
金额：
$ 38.37万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-20 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10667437
关键词：
Address Adult Affect Area Attention Attention deficit hyperactivity disorder Behavior Behavioral Brain Child Cognition Disorders Dopamine Exhibits Eye Movements Funding Goals Image Lead Maintenance Mediating Mental Health Mental disorders Methods Midbrain structure Motivation Motor Movement Neurons Parietal Parietal Lobe Perception Prefrontal Cortex Preparation Primates Research Role Saccades Sensory Shapes Short-Term Memory Signal Transduction Source Stimulus Structure System Testing Vision Visual Visual Cortex Visual Perception Visual System Visual attention Work attentional control behavior influence combat contextual factors density experimental study extrastriate extrastriate visual cortex frontal eye fields gaze innovation lateral intraparietal area luminance neural neural circuit neural correlate neuromechanism neurophysiology nonhuman primate oculomotor public health relevance retinal imaging selective attention superior colliculus Corpora quadrigemina tool virtual visual cognition visual control visual information visual processing visual stimulus

项目摘要

A fundamental fact of vision is that our perception of the external world is shaped by a number of behavioral and contextual factors. These factors include visual selective attention, in which sensory information is filtered in favor of items that are behaviorally and contextually relevant. In addition, it includes the modulation of visual processing during saccadic eye movements which occur several times each second. These factors are known to modulate the processing of visual information and to contribute to adaptive visually guided behavior. In the primate brain, the visual and oculomotor systems are highly interconnected, and past work has shown that movement-related signals exert robust influences on visual processing in visual cortex. The current proposal focuses on addressing key questions concerning the role of gaze control mechanisms in visual selection and visual stability, two ways in which those mechanisms clearly influence visual perception and cognition. These questions will be addressed using a broad set of innovative approaches and tools including newly developed, large-scale, high-density Neuropixels (NP) probes made specifically for use in nonhuman primates. In this first aim, we will test the role of persistent activity in the selection of visual signals and in visually guided saccades in a set of key, complementary experiments that include large-scale neurophysiological recordings with primate NP probes. Our hypothesis is that persistent activity in the frontal eye field (FEF) serves primarily to select the visual information required to guide saccadic eye movements, and that this function is mediated by dopamine D1Rs. In the second aim, we will address a major open question regarding the basis of stimulus-driven attention by testing the contribution of posterior parietal cortex (PPC) to the representation of visual salience in the brain, and to saliency-driven behavior. Experiments in this aim combine the use of reversible inactivation of PPC with large- scale neurophysiological recordings and behavior. In the third aim, we will address another major open question regarding the basis of the distortions in vision that occur during saccadic eye movements. We will leverage the use of large-scale recordings, and the use of reversible parietal inactivation to test the role of PPC in perisaccadic changes in visual processing within extrastriate visual cortex and the FEF. Overall, our focus on the influence of gaze control mechanisms on visual processing, combined with our use of state-of-the-art neurophysiological approaches and causal methods, are likely to produce results that exert a large and sustained impact on our understanding of the neural mechanisms of visual perception and cognition.

视力的基本事实是，我们对外部世界的看法是由许多人塑造的行为和上下文因素。这些因素包括视觉选择性关注，其中感官信息过滤以在行为和上下文相关的项目中过滤。此外，它包括调制每秒发生几次的刺激性眼动过程中的视觉处理。这些因素是已知可以调节视觉信息的处理并有助于自适应视觉引导行为。在灵长类动物的大脑中，视觉和动眼系统是高度互连的，过去的工作表明与运动有关的信号对视觉皮层中的视觉处理产生了强大的影响。当前的建议专注于解决有关目光控制机制在视觉选择和视觉稳定性，这些机制显然影响视觉感知和认知的两种方式。这些将使用广泛的创新方法和工具来解决问题，包括新开发，专门用于非人类灵长类动物的大规模高密度神经偶像（NP）探针。在第一个目的，我们将测试持续活动在选择视觉信号和视觉引导的扫视中的作用一组钥匙，互补的实验，其中包括带有灵长类动物NP的大规模神经生理记录探针。我们的假设是额眼场（FEF）中的持续活动主要用于选择视觉引导saccadic眼动的信息，并且该功能是由多巴胺D1RS介导的。在第二个目标中，我们将解决有关刺激驱动的关注基础的主要开放问题测试后顶叶皮层（PPC）对大脑视觉显着性表示的贡献以显着驱动的行为。此目标的实验结合了PPC的可逆失活的使用缩放神经生理记录和行为。在第三个目标中，我们将解决另一个主要的公开问题关于在眼球运动中发生的视力扭曲的基础。我们将利用使用大规模记录，并使用可逆顶叶灭活来测试PPC在Perisaccadic中的作用腹部外视皮层和FEF内视觉处理的变化。总体而言，我们关注的关注视觉处理上的凝视控制机制，结合我们使用最先进的神经生理学方法和因果方法可能会产生对我们的巨大且持续影响的结果了解视觉感知和认知的神经机制。

项目成果

期刊论文数量（46）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Saccades and shifting receptive fields: anticipating consequences or selecting targets?

DOI：
10.1016/j.tics.2014.10.002
发表时间：
2014-12
期刊：
TRENDS IN COGNITIVE SCIENCES
影响因子：
19.9
作者：
Zirnsak, Marc;Moore, Tirin
通讯作者：
Moore, Tirin

Persistent spatial information in the frontal eye field during object-based short-term memory.

DOI：
10.1523/jneurosci.1450-12.2012
发表时间：
2012-08-08
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
0
作者：
Clark KL;Noudoost B;Moore T
通讯作者：
Moore T

Working memory gates visual input to primate prefrontal neurons.

DOI：
10.7554/elife.64814
发表时间：
2021-06-16
期刊：
eLife
影响因子：
7.7
作者：
Noudoost B;Clark KL;Moore T
通讯作者：
Moore T

Intrinsic timescales in the visual cortex change with selective attention and reflect spatial connectivity.

DOI：
10.1038/s41467-023-37613-7
发表时间：
2023-04-03
期刊：
NATURE COMMUNICATIONS
影响因子：
16.6
作者：
Zeraati, Roxana;Shi, Yan-Liang;Steinmetz, Nicholas A.;Gieselmann, Marc A.;Thiele, Alexander;Moore, Tirin;Levina, Anna;Engel, Tatiana A.
通讯作者：
Engel, Tatiana A.

Exploration Disrupts Choice-Predictive Signals and Alters Dynamics in Prefrontal Cortex.