A self-capacitance driven wearable electromyometrial imaging system for maternal and fetal monitoring during pregnancy and labor

一种自电容驱动的可穿戴式肌电成像系统，用于妊娠和分娩期间的母婴监测

• 批准号: 10666402
• 负责人: Chuan Wang
• 金额: $ 33.47万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10666402
• 关键词: 3-Dimensional; Abdomen; Address; Adoption; Area; Benchmarking; Birth; Body Surface; Body of uterus; Brain; Cerebral Palsy; Child; Clinical; Clinical Treatment; Data; Delivery Rooms; Electric Capacitance; Electrodes; Engineering; Fetal Monitoring; Fetal Mortality Statistics; Geometry; Health; Heart; Heart failure; Home; Human; Image; Imaging technology; Impaired cognition; Joints; Knowledge; Magnetic Resonance Imaging; Maps; Measurement; Measures; Medical center; Mental Retardation; Methods; Monitor; Morphologic artifacts; Motion; Organ; Outcome; Outpatients; Pathologic; Patients; Pattern; Performance; Perinatology; Persons; Pregnancy; Pregnant Women; Premature Birth; Premature Labor; Printing; Research; Research Activity; Resolution; Risk; Schedule; Signal Transduction; Site; Surface; System; Technology; Telemetry; Transducers; Translating; United States; Universities; Uterine Contraction; Uterine Monitoring; Uterus; Validation; Visual impairment; Washington; Wireless Charging; clinical application; clinical translation; cohort; cost; density; design; effectiveness evaluation; electrical property; hearing impairment; human subject; imaging platform; imaging study; imaging system; improved; instrument; instrumentation; mechanical properties; member; new technology; novel; patient mobility; portability; prevent; sensor; temporal measurement; tool; treatment strategy; wireless

PROJECT SUMMARY Approximately 10% of pregnant women give birth preterm In the United States and worldwide, which not only results in a high rate of fetal mortality but also puts the children at a lifelong risk of negative health consequences such as cerebral palsy, mental retardation, and visual and hearing impairments. Despite years of research, the mechanisms of initiation and propagation of uterine contractions resulting in preterm labor and birth remain unknown. In large part, this is because of our limited ability to monitor the human uterine contractions with sufficient spatial and temporal resolutions. This leads to a lack of critical knowledge of the pathologic factors that alter the normal uterine maturation, initiate preterm labor, and result in preterm birth. In order to address this unmet clinical and research need, our team has recently developed a novel high-resolution and noninvasive electromyometrial imaging (EMMI) system, which uses up to 256 unipolar electrodes to measure uterine electrograms from the patient's abdomen surface and then combines the patient-specific body-uterus geometry obtained by magnetic resonance imaging (MRI) to generate accurate and robust three-dimensional maps of uterine electrical activity during contractions. Because such a powerful experimental tool could permit closer and more precise study of birth-related risks and improve maternal and child outcomes, we believe there could be a significant clinical impact for us to develop a low-cost, wireless, and wearable version in order to make this imaging technology more accessible for outpatient or in-home monitoring settings. We propose to develop and validate the functionality of a unique wearable EMMI system with printed disposable electrodes, wireless power delivery, and telemetry for continuously monitoring of the uterine contraction activities in ambulatory patients. The proposed research activity will involve developing of ultrathin soft sensor patches with printed stretchable electrodes for recording high quality electrograms from the patient’s abdomen and generating accurate and robust 3D maps of the uterine surface; investigating and designing a novel self-capacitance based wireless power transfer instrumentation for wirelessly powering all the sensing and telemetry circuits at each recording site in a fully distributed high-density imaging system; validating the wireless and wearable EMMI system in human subjects and benchmarking its performance against “gold standard” wired EMMI system. Upon successful completion of this study, the entirely new wearable, wireless, and batteryless imaging system developed in the project will facilitate EMMI's clinical translations, allow it to be used outside the delivery room for outpatient setting or in-home monitoring applications, and ultimately enable us to leverage the electrical mapping data for evaluating uterine electrical maturation and contraction patterns during pregnancy and labor and use the results to better understand and treat preterm birth.

项目摘要 大约10％的孕妇在美国和世界范围 导致胎儿死亡率较高，但也使儿童终生有负面影响的影响 例如脑瘫，智力低下以及视觉和听力障碍。尽管有多年的研究， 子宫收缩的起始和传播机制导致早产和出生 未知。在很大程度上，这是因为我们与人子宫收缩的能力有限 足够的空间和临时决议。这导致缺乏对病理因素的批判性知识 改变正常的子宫成熟，开始早产并导致早产。为了解决这个问题 未满足的临床和研究需求，我们的团队最近开发了一种新颖的高分辨率和无创的 肌分泌成像（EMMI）系统，该系统最多使用256个单极电极来测量子宫 来自患者腹部表面的电电图，然后结合患者特异性的身体几何形状 通过磁共振成像（MRI）获得，以生成准确稳健的三维图的 子宫电活动在收缩期间。因为如此强大的实验工具可以允许更接近，并且 更精确地研究与出生有关的风险并改善了母亲和儿童的结果，我们认为可能会有一个 为我们制定低成本，无线和可穿戴版本的临床影响很大 成像技术更容易用于门诊或家庭监控设置。 我们建议开发和验证带有印刷的独特可穿戴emmi系统的功能 一次性电极，无线电源和遥测，用于连续监测子宫 门诊患者的收缩活动。拟议的研究活动将涉及开发超薄 软传感器贴片带有可伸缩电子的贴片，用于记录患者的高质量电子 腹部并产生子宫表面的准确，稳健的3D地图；调查和设计 基于新型的基于自我电气的无线电力传输仪器，用于无线为所有感应和 完全分布的高密度成像系统中每个录制位点的遥测电路；验证无线 和可穿戴的Emmi系统中的人类受试者，并根据“黄金标准”的有线测试其性能 Emmi系统。成功完成这项研究后，全新的可穿戴，无线和无电池 该项目中开发的成像系统将有助于Emmi的临床翻译，允许它在以外使用 用于门诊设置或家庭监控应用的运送室，并最终使我们能够利用 用于评估子宫电力成熟和收缩模式的电映射数据 和劳动并利用结果更好地理解和治疗早产。

项目成果

Ferroelectret nanogenerators for the development of bioengineering systems

• DOI: 10.1016/j.xcrp.2023.101388
• 发表时间: 2023-05-17
• 期刊: CELL REPORTS PHYSICAL SCIENCE
• 影响因子: 8.9
• 作者: Li，Wei;Cao，Yunqi;Sepulveda，Nelson
• 通讯作者: Sepulveda，Nelson

A Portable and a Scalable Multi-Channel Wireless Recording System for Wearable Electromyometrial Imaging.

用于可穿戴肌电成像的便携式且可扩展的多通道无线记录系统。

• DOI: 10.1109/tbcas.2023.3278104
• 发表时间: 2023
• 期刊: IEEE transactions on biomedical circuits and systems
• 影响因子: 5.1
• 作者: Li,Weilun;Xiao,Zhili;Zhao,Junyi;Aono,Kenji;Pizzella,Stephanie;Wen,Zichao;Wang,Yong;Wang,Chuan;Chakrabartty,Shantanu
• 通讯作者: Chakrabartty,Shantanu