A wearable monitor for pediatric asthma: Developing environmental and breath sensors linked to spirometry

小儿哮喘可穿戴监测仪：开发与肺活量测定相关的环境和呼吸传感器

• 批准号: 9077049
• 负责人: CRISTINA ELIZABETH DAVIS
• 金额: $ 145.42万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2020-06-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9077049
• 关键词: Adolescent; Adult; Affect; Asthma; Benchmarking; Biological Markers; Breath Tests; Child; Childhood; Childhood Asthma; Chronic; Clinical; Clinical Trials; Clothing; County; Data; Detection; Devices; Diagnosis; Diagnostic; Disease; Drug usage; Eicosanoids; Enrollment; Exhalation; Family; Foundations; Funding; Goals; Health; Hospitals; Inflammatory; Inhalators; Laboratories; Laboratory Research; Life; Link; Lung; Lung Inflammation; Maps; Measurement; Measures; Monitor; Outcome; Patients; Prevalence; Pulmonary Function Test/Forced Expiratory Volume 1; Quality of life; Respiratory physiology; Schools; Spirometry; Surveys; Symptoms; System; Technology; Testing; Time; United States; Universities; Visit; Work; asthmatic; base; design; economic impact; environmental chemical; graphical user interface; improved; inflammatory lung disease; inner city; instrument; novel; programs; prototype; public health relevance; research clinical testing; sensor; system architecture

 DESCRIPTION (provided by applicant): Asthma is a progressive inflammatory disease of the lungs that leads to structural airway changes and debilitating symptoms in many affected children and adults. It is the most common chronic childhood disease, and asthma attacks are the most common reason children miss school. More than 5 million children have asthma and the prevalence of asthma in some inner cities in the United States is greater than 20%. While environmental triggers are recognized as key parameters in managing pediatric asthma, it has been challenging to concurrently measure health metrics in children at the same time as quantifying the triggers to which they are being exposed. A technology gap has existed for portable monitoring systems that can perform these functions simultaneously while continuously logging data. This project will develop a safe and effective wearable diagnostic health monitoring sensor for children with asthma to improve their daily quality of life. It will combine four major functions in a single packaged system worn by the user: (1) routine portable spirometry and pulmonary lung function measurements can be taken and logged by the user on-demand; (2) exhaled breath oxylipin biomarkers can be measured and logged in near-real-time by the user on-demand; (3) environmental chemical monitoring will be continuously logged to understand background triggers of asthma; (4) patient symptoms and drug use will be manually logged by the user enabled by an intuitive graphical user interface. In a prior pediatric asthma clinical trial using breath monitoring, we found that eicosanoids were measureable in exhaled breath and were consistent with the levels needed for detection using the novel and portable instruments we have developed. For this period, we aim: 1) To establish a wearable sensor system architecture integrating our modular components into a total breath monitoring system capable of: spirometry, real-time eicosanoid measurements, and continuous environmental chemical monitoring, and 2) To enroll 10 adolescent asthmatic subjects to use the new wearable sensor in a longitudinal pilot clinical trial over 8 months to test the hypothesis that increased breath eicosanoid levels correlate with increased asthma symptoms and worse lung function. At the end of this study, we anticipate our prototype system will have been benchmarked for use specifically in pediatric asthma metabolite monitoring. Our goal is to improve asthma monitoring for all children.

 描述（由申请人提供）：哮喘是一种进行性肺部炎症性疾病，会导致许多受影响的儿童和成人出现气道结构变化和衰弱症状。它是最常见的慢性儿童疾病，而哮喘发作是儿童最常见的原因。超过 500 万儿童患有哮喘，美国一些内城区的哮喘患病率超过 20% 虽然环境触发因素被认为是治疗小儿哮喘的关键参数，但同时衡量健康状况一直是一项挑战。便携式监测系统在持续记录数据的同时执行这些功能，目前存在技术差距。该项目将开发一种安全有效的可穿戴诊断健康监测系统。它将四个主要功能结合在用户佩戴的单个封装系统中：（1）用户可以进行常规便携式肺活量测定和肺功能测量并记录。 (2)呼气用户可以按需近乎实时地测量和记录氧脂质生物标记物；(3) 将持续记录环境化学监测，以了解哮喘的背景触发因素；(4) 将手动记录患者症状和药物使用情况；在之前使用呼吸监测的儿科哮喘临床试验中，我们发现呼出气中的类花生酸含量与使用我们开发的新型便携式仪器检测所需的水平一致。这段时间，我们的目标是：1) 建立一个可穿戴传感器系统架构，将我们的模块化组件集成到一个全面呼吸监测系统中，该系统能够：肺活量测定、实时类二十烷酸测量和连续环境化学监测，以及 2) 招募 10 名青少年哮喘受试者使用新的可穿戴传感器在为期 8 个月的纵向试点临床试验中检验了这一假设 呼吸类二十烷酸水平的增加与哮喘症状的增加和肺功能的恶化相关。在这项研究结束时，我们预计我们的原型系统将专门用于小儿哮喘代谢监测。我们的目标是改善所有儿童的哮喘监测。 。