Administrative core

行政核心

基本信息

批准号：
10540796
负责人：
Anita Sil
金额：
$ 23.4万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-01-01 至 2026-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10540796
关键词：
Area Arizona Basic Science Biological Models Biology Chronic Clinical Clinical Investigator Coccidioides Coccidioidomycosis Collaborations Communicable Diseases Core Facility Cytometry Data Development Diagnostic Disease Progression Elements Ensure Feedback Fostering Funding Genetic Goals Immune response Immunology Infection Leadership Meningitis Mentors Metabolic Metagenomics Microbiology Molecular Biology Mucosal Immunity Neurologist Occupational activity of managing finances Participant Pathogenesis Pathway interactions Patient Care Patients Persons Physicians Productivity Research Research Personnel Sampling Scientist Seasons Subgroup Technology Teleconferences The science of Mycology Therapeutic Universities Vaccine Design Virulence combat fungus infectious meningitis insight meetings member mutant next generation sequencing novel pathogen programs recruit single-cell RNA sequencing success synergism transcriptomics

Area Arizona Basic Science Biological Models Biology Chronic Clinical Clinical Investigator Coccidioides Coccidioidomycosis Collaborations Communicable Diseases Core Facility Cytometry Data Development Diagnostic Disease Progression Elements Ensure Feedback Fostering Funding Genetic Goals Immune response Immunology Infection Leadership Meningitis Mentors Metabolic Metagenomics Microbiology Molecular Biology Mucosal Immunity Neurologist Occupational activity of managing finances Participant Pathogenesis Pathway interactions Patient Care Patients Persons Physicians Productivity Research Research Personnel Sampling Scientist Seasons Subgroup Technology Teleconferences The science of Mycology Therapeutic Universities Vaccine Design Virulence combat fungus infectious meningitis insight meetings member mutant next generation sequencing novel pathogen programs recruit single-cell RNA sequencing success synergism transcriptomics

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项目摘要

Project Summary (Core 1, Administrative Core, Sil) Our goal is to establish a vibrant and productive Coccidioidomycosis Collaboration Research Center (CCRC) entitled Molecules and Pathways at the Coccidioides Host-Pathogen Interface. We are bringing together a cadre of basic scientists, clinical investigators, and technologists who will interrogate the pathogenesis of Coccidioides and the nuances of the host response in model systems, in chronic coccidiomycosis, and in coccidioidal meningitis. Taken together, we will provide insights that will bridge gaps in diagnostics, therapeutics, and potentially vaccine design for coccidioidomycosis. The Administrative Core is key to integrating the findings of each project, fostering synergy between our groups, and recruiting junior investigators to the coccidioidomycosis field via the mentored Developmental Research Program initiative. We will provide scientific, organizational, and administrative leadership as well as financial oversight. Scientific progress will be fostered and evaluated by extensive review of data at quarterly meetings attended by all of the CCRC members. In addition, we will have an annual in-person meeting for all participants. All investigators affiliated with each project and core will evaluate the scientific progress of each group and give constructive feedback that will support trainee development while fostering scientific excellence. Additionally, if this CCRC is funded, we will establish an external scientific advisory board (SAB) comprised of experts in basic mycology, microbiology, immunology of fungi, infectious disease, and host response. Thus we expect a unique synergy between all elements of this proposal that will allow us to support both seasoned and junior investigators in the Coccidioides field and make novel and critical contributions to diagnostic and therapeutic strategies to combat coccidioidomycosis.

项目摘要（核心1，行政核心，SIL）我们的目标是建立一个充满活力和富有成效的球虫菌病合作研究中心（CCRC）标题为Coccidioides宿主 - 病原体界面的分子和途径。我们带来一组基础科学家，临床研究人员和技术人员将询问发病机理在模型系统中，慢性球菌病和宿主反应的细微差别，在球虫脑膜炎。综上所述，我们将提供洞察力，以弥合诊断，治疗学，以及可能用于球虫菌病的疫苗设计。行政核心是整合每个项目发现的关键，从而促进我们的协同作用小组，并通过指导的发展招募初级研究人员到球虫病领域研究计划倡议。我们将提供科学，组织和行政领导以及财务监督。科学进步将通过对季度的数据进行广泛审查来促进和评估所有CCRC成员都参加了会议。此外，我们将为所有人举行年度面对面会议参与者。所有隶属于每个项目和核心的研究人员将评估每个项目的科学进步小组并提供建设性的反馈，以支持学员发展，同时促进卓越的科学卓越。此外，如果此CCRC资助，我们将建立一个由外部科学咨询委员会（SAB）组成的基本真菌学，微生物学，真菌免疫学，传染病和宿主反应的专家。因此我们期望本提案的所有要素之间有独特的协同作用，这将使我们能够支持经验丰富的和球虫下的初级研究人员，并为诊断和打击球虫菌病的治疗策略。