Development of Advanced C-arm Cone-Beam CT for the Treatment of Liver Cancer
先进C型臂锥束CT治疗肝癌的开发
基本信息
- 批准号:8616609
- 负责人:
- 金额:$ 48.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-07-01 至 2018-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdvanced DevelopmentAlgorithmsAnatomyAsorbicapCathetersClinicalContrast MediaDataDevelopmentDoseEvaluation StudiesFluoroscopyHepaticImageImage-Guided SurgeryImageryInterruptionInterventionKidneyLeadLesionLifeLiverLiver neoplasmsLungMalignant NeoplasmsMalignant neoplasm of liverMethodsMorphologic artifactsNephrotoxicNoiseOperative Surgical ProceduresPatientsProceduresProtocols documentationRadiationRadiation therapyResearchResearch DesignRotationSamplingScanningSterile coveringsTechniquesTechnologyTherapeutic EmbolizationTimeTissuesWorkarmbasecancer therapyclinically significantcone-beam computed tomographydesigndetectorfeedinghazardimage reconstructionimaging modalityimprovedinnovationinsightliver visualizationpreclinical studypreventprogramspublic health relevancereconstructionstandard of caretumor
项目摘要
Abstract/Project Summary
The objective of this program is to improve cone-beam computed tomography (CBCT) imaging performed on
an interventional C-arm for guiding catheter-directed embolization of liver tumor in particular, and multiple other
interventional procedures. The current standard of care for hepatic catheter directed therapy uses an
interventional C-arm and injected contrast agent to visualize tumor and its feeding vessels. C-arm CBCT can
be used to understand the lesion anatomy, allowing 3D visualization of the tumor and feeding vessels.
However, current C-arm CBCT is far from being optimized for the application due to a number of important
limitations concerning exam time, radiation dose, image quality, and intrusiveness to workflow. These
limitations can be addressed through the development of innovative CBCT scans and optimization-based
reconstructions. In the project, we focus on tackling the practical limitations of the C-arm CBCT in image-
guided liver-tumor catheter delivery through the development of innovative scans and optimization-based
reconstructions, and demonstrating their translational potential to clinical tasks of image-guided liver-tumor
treatment. The specific aims of the project include (1) to develop optimization-based reconstruction for
improving current C-arm imaging, (2) to develop scans and optimization-based reconstruction for further
improving C-arm imaging, and (3) to verify, characterize, and evaluate optimization-based reconstructions. The
clinical and technical significances of the project are high, because it can directly impact significantly
intervention and treatment of liver-cancer and other forms of cancer, particularly, in the lung and kidney, and
because it can lead to the development of advanced C-arm CBCT technology for addressing technical
challenges such as sparse-view, truncation, and limited-angular-range problems of extremely high practical
merit. The project has a high level of innovation, because it includes numerous creative ideas and methods for
enhancing workflow and for reducing contrast volume, radiation dose, and patient discomfort.
摘要/项目摘要
该计划的目标是改进锥束计算机断层扫描 (CBCT) 成像
特别是用于引导肝肿瘤导管定向栓塞的介入 C 形臂,以及其他多种
介入程序。目前肝导管定向治疗的护理标准采用
介入 C 形臂和注射造影剂以可视化肿瘤及其供给血管。 C型臂CBCT可以
用于了解病变解剖结构,实现肿瘤和喂养血管的 3D 可视化。
然而,由于许多重要的原因,当前的 C 臂 CBCT 远未针对应用进行优化。
有关检查时间、辐射剂量、图像质量和对工作流程的干扰的限制。这些
可以通过开发创新的 CBCT 扫描和基于优化的方法来解决局限性
重建。在该项目中,我们重点解决 C 型臂 CBCT 在图像方面的实际局限性
通过开发创新扫描和基于优化的引导肝肿瘤导管输送
重建,并展示其在图像引导肝脏肿瘤临床任务中的转化潜力
治疗。该项目的具体目标包括(1)开发基于优化的重建
改进当前的 C 形臂成像,(2) 开发扫描和基于优化的重建以进一步
改进 C 形臂成像,以及 (3) 验证、表征和评估基于优化的重建。这
该项目的临床和技术意义很高,因为它可以直接产生重大影响
肝癌和其他形式的癌症,特别是肺癌和肾癌的干预和治疗,以及
因为它可以带动先进C型臂CBCT技术的发展,以解决技术问题
稀疏视图、截断和有限角度范围问题等实用性极高的挑战
优点。该项目具有很高的创新水平,因为它包含了众多的创意想法和方法
增强工作流程并减少造影剂体积、辐射剂量和患者不适。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(3)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
XIAOCHUAN PAN其他文献
XIAOCHUAN PAN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('XIAOCHUAN PAN', 18)}}的其他基金
Algorithm-Enabled Auto-Calibrating Quantitative Dual-Energy CT
支持算法的自动校准定量双能 CT
- 批准号:
10448987 - 财政年份:2022
- 资助金额:
$ 48.39万 - 项目类别:
Advanced iterative image reconstruction for digital breast tomosynthesis - Resubmission 01
用于数字乳腺断层合成的高级迭代图像重建 - 重新提交 01
- 批准号:
10224861 - 财政年份:2018
- 资助金额:
$ 48.39万 - 项目类别:
Advanced iterative image reconstruction for digital breast tomosynthesis - Resubmission 01
用于数字乳腺断层合成的高级迭代图像重建 - 重新提交 01
- 批准号:
9978584 - 财政年份:2018
- 资助金额:
$ 48.39万 - 项目类别:
36th Annual International Conference of the IEEE Engineering in Medicine and Biol
第 36 届 IEEE 医学和生物工程国际年会
- 批准号:
8720474 - 财政年份:2014
- 资助金额:
$ 48.39万 - 项目类别:
Development of Advanced C-arm Cone-Beam CT for the Treatment of Liver Cancer
先进C型臂锥束CT治疗肝癌的开发
- 批准号:
9305887 - 财政年份:2014
- 资助金额:
$ 48.39万 - 项目类别:
Digital Specimen Tomosynthesis for Volumetric Imaging of Lumpectomy Specimens
用于肿瘤切除标本体积成像的数字标本断层合成
- 批准号:
9085109 - 财政年份:2014
- 资助金额:
$ 48.39万 - 项目类别:
Digital Specimen Tomosynthesis for Volumetric Imaging of Lumpectomy Specimens
用于肿瘤切除标本体积成像的数字标本断层合成
- 批准号:
8766676 - 财政年份:2014
- 资助金额:
$ 48.39万 - 项目类别:
International Symposium on Biomedical Imaging: from Nano to Macro 2011 (ISBI2011)
生物医学成像国际研讨会:从纳米到宏观2011 (ISBI2011)
- 批准号:
8133639 - 财政年份:2011
- 资助金额:
$ 48.39万 - 项目类别:
31st Annual International Conference of IEEE Engineeering in Medicine and Biology
第 31 届 IEEE 医学和生物学工程国际会议
- 批准号:
7744371 - 财政年份:2009
- 资助金额:
$ 48.39万 - 项目类别:
Optimized Cone-Beam CT for Image-Guided Radiation Therapy
用于图像引导放射治疗的优化锥束 CT
- 批准号:
7477349 - 财政年份:2007
- 资助金额:
$ 48.39万 - 项目类别:
相似国自然基金
减少编程错误:基于认证内核的全新的快捷依赖类型PiSigma高级编程语言开发
- 批准号:61070023
- 批准年份:2010
- 资助金额:30.0 万元
- 项目类别:面上项目
相似海外基金
MASS: Muscle and disease in postmenopausal women
MASS:绝经后妇女的肌肉和疾病
- 批准号:
10736293 - 财政年份:2023
- 资助金额:
$ 48.39万 - 项目类别:
Machine Learning with Scintillation Photon Counting Detectors to Advance PET Imaging Performance
利用闪烁光子计数探测器进行机器学习以提高 PET 成像性能
- 批准号:
10742435 - 财政年份:2023
- 资助金额:
$ 48.39万 - 项目类别:
Small Molecule Therapeutics for Sickle Cell Anemia
镰状细胞性贫血的小分子疗法
- 批准号:
10601679 - 财政年份:2023
- 资助金额:
$ 48.39万 - 项目类别:
Addressing Algorithmic Unreliability and Dataset Shift in EHR-based Risk Prediction Models
解决基于 EHR 的风险预测模型中的算法不可靠性和数据集转移
- 批准号:
10679376 - 财政年份:2023
- 资助金额:
$ 48.39万 - 项目类别:
HORMAD-specific TGF-beta resistant memory T cells for treatment of patients with Gastro-esophageal Cancer
HORMAD 特异性 TGF-β 耐药性记忆 T 细胞用于治疗胃食管癌患者
- 批准号:
10731407 - 财政年份:2023
- 资助金额:
$ 48.39万 - 项目类别: