Core 5: Integrated Support Services

核心 5：综合支持服务

• 批准号: 10663837
• 负责人: RONALD B CORLEY
• 金额: $ 170.47万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663837
• 关键词: Accreditation; Address; Anatomy; Animal Experimentation; Animal Model; Animal Technicians; Animals; Autopsy; Basic Science; Biotechnology; Boston; Cells; Clinic; Clinical; Clinical Chemistry; Collaborations; Communities; Comparative Pathology; Competence; Containment; Development; Diagnostic; Emerging Communicable Diseases; Ensure; Equipment and supply inventories; Faculty; Fees; Fees and Charges; Flow Cytometry; Fostering; Funding; Future; Goals; IACUC; Image; Immunology; Individual; Infectious Agent; Infectious Diseases Research; Infrastructure; Institution; International; Laboratories; Libraries; Light; Link; Maintenance; Methodology; Methods; Microscopy; Monitor; Outcome; Pathologist; Pharmacologic Substance; Private Sector; Procedures; Protocols documentation; Reagent; Regulation; Research; Research Personnel; Research Project Grants; Research Support; Resources; Safety; Sampling; Sampling Studies; Schedule; Science; Scientific Inquiry; Scientist; Services; Specimen; Technical Expertise; Technology; Therapeutic; Time; Tissues; Training; Universities; Vaccines; Veterinary Pathology; Viral; Virus; Visual; Work; comparative; cost; frontier; high throughput screening; innovation; instrumentation; operation; pathogen; programs; recruit; research and development; response; screening; single cell sequencing; skills; small molecule inhibitor; tool; translational research program; viral genomics; virology

Core 5: Integrated Research Support Services Abstract The Integrated Research Support Services (ISS) Core serves to organize shared services that are provided to the research community within the NEIDL. These services support BSL-4/ABSL-4 studies to ensure that each investigator does not have to recreate infrastructure and expertise in their laboratories in order to carry out their funded research programs. The core will develop schedules and manage costs so that reasonable and responsible user fees are charged to investigators using these services to offset overall costs, as appropriate. The services offered evolve over time such that new services can be offered as the needs of the research community changes. Currently, core is broadly separated into the Animal Research Support Services, and the BSL-4 Laboratory Services. Animal Research Services includes trained veterinary professionals and veterinary technicians who collaborate with faculty to carry out studies in various animal models. The team is trained on a number of procedures to increase safety when working with animals, especially those that require the use of sharps. This unit also works with investigators to ensure the humane use of animals and to comply with institutional animal care and use committee requirements. Within the BSL-4 Laboratory Services, a number of units exist to support the BSL-4 and ABSL-4 studies. These include Veterinary Pathology (anatomic and laboratory) Service which oversees the necropsy services, storage and maintenance of the samples in compliance with the CDC select agent program, and is responsible for establishing and validating the inactivation protocols required to move tissues to the BSL-2. The Veterinary Pathologist is responsible for clinical chemistry. Virology Services is responsible for receiving, validating, and inventorying viruses that are utilized in BSL-4 research. This includes generating master and working stocks as well as maintaining an accurate inventory of agents. This core also develops advanced virologic tools as needed. The Viral Genomic Tracking and Single Cell omics Resource is responsible for ensuring the fidelity of viral stocks from VS given to investigators for their research, and for initiating single cell sequencing and single virus omics technologies in the BSL-4. The Imaging Services Unit provides several platforms to study living tissue specimens infected with BSL-4 pathogens, including Light Sheet microscopy. Many of the BSL-4 investigators rely on services from the NEIDL Comparative Pathology Laboratory (NCPL). Immunology Services provides training, guidance and maintenance of advanced immunology instrumentation inside the BSL-4 footprint, including flow cytometry. High-throughput screening has been operationalized to include automated visual screening of virus infected cells treated with small molecule inhibitors, and can be adapted to any virus or cell target. Linking the Clinic to NEIDL Programs includes a clinician whose responsibilities are to link clinical outcomes to the studies that are undertaken in the NEIDL (for comparative purposes) as well as to engage with clinical programs to obtain clinical samples for studies.

核心5：综合研究支持服务 抽象的 综合研究支持服务（ISS）核心有助于组织提供给的共享服务 NEIDL内的研究界。这些服务支持BSL-4/ABSL-4研究，以确保每个研究 调查人员不必在其实验室中重新创建基础设施和专业知识，以进行他们的 资助的研究计划。核心将制定时间表并管理成本，以便合理，并且 负责任的用户费用向调查人员使用这些服务收取，以抵消合适的总体成本。 随着时间的推移，提供的服务可以作为研究的需求提供新服务 社区变化。目前，核心已广泛分为动物研究支持服务， BSL-4实验室服务。动物研究服务包括训练有素的兽医专业人士和兽医 与教职员工合作进行各种动物模型进行研究的技术人员。该团队接受了训练 与动物一起工作时提高安全性的程序数量，尤其是那些需要使用的程序 尖锐。该单元还与调查人员合作，以确保人道使用动物并遵守 机构动物护理和使用委员会要求。在BSL-4实验室服务中，许多 存在用于支持BSL-4和ABSL-4研究的单位。这些包括兽医病理学（解剖和 实验室）服务，以监督样品的死灵尸体服务，存储和维护 遵守CDC选择代理程序，并负责建立和验证 将组织移至BSL-2所需的灭活方案。兽医病理学家负责 临床化学。病毒学服务负责接收，验证和库存病毒 用于BSL-4研究。这包括生成大师和工作库存以及维护 准确的代理清单。该核心还根据需要开发先进的病毒工具。病毒基因组 跟踪和单元格资源负责确保从vs提供的病毒库存的保真度 研究人员进行研究，并在中启动单细胞测序和单个病毒绝语技术 BSL-4。成像服务单元提供了多个研究感染的活组织标本的平台 BSL-4病原体，包括光片显微镜。许多BSL-4调查人员都依靠 NEIDL比较病理实验室（NCPL）。免疫学服务提供培训，指导和 维护BSL-4足迹内的高级免疫学仪器，包括流式细胞仪。 高通量筛选已被运营，包括对感染病毒的自动视觉筛查 用小分子抑制剂处理的细胞，可以适应任何病毒或细胞靶标。将诊所与 NEIDL计划包括一个临床医生，其责任是将临床结果与研究联系起来 在NEIDL（出于比较目的）中进行，并参与临床计划以获得 研究的临床样本。