Caenorhabditis Genetics Center

秀丽隐杆线虫遗传学中心

• 批准号: 8866245
• 负责人: Ann E. Rougvie
• 金额: $ 42.49万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8866245
• 关键词: Aging; Alzheimer' s Disease; Animal Model; Animals; Anthelmintics; Apoptosis; Applied Research; Area; Basic Science; Biological; Biology; Caenorhabditis; Caenorhabditis elegans; Chromosomal Rearrangement; Chromosomes; Collection; Communities; Country; Disease; Education; Educational process of instructing; Generations; Genes; Genetic; Genome; Goals; Health; Human; Human Development; Individual; International; Label; Livestock; Locales; Malignant Neoplasms; Marketing; MicroRNAs; Mission; Modeling; Mutation; Nematoda; Neurodegenerative Disorders; Parasitic nematode; Parkinson Disease; Policies; Publishing; RNA Interference; Recovery; Reporter Genes; Research; Research Personnel; Resources; Science; Services; Sterility; System; Technology; Transgenic Organisms; Work; base; cost; insight; model organisms databases; null mutation; repository; response; tool; tumor progression; web site

The overall objective of the Caenorhabditis Genetics Center (CGC) is to promote research on the small metazoan Caenorhabditis elegans by acquiring, maintaining, and distributing genetically characterized nematode stocks. Researchers throughout the world use genetic stocks obtained from the CGC in diverse basic and applied research endeavors. Studies using this premier model organism have led to fundamental insights into basic biological mechanisms, including the genetic basis of programmed cell death, the discovery of microRNAs, and the mechanism of RNA interference in animals. The nematode has also proved important for understanding mechanisms of cancer progression and other diseases including Alzheimer's and Parkinson's, as well as for revealing basic mechanisms underlying human development. In addition, C. elegans serves as a key model for illuminating our understanding of parasitic nematodes with relevance to human and livestock health. As the sole general stock center for the nematode C. elegans, the CGC is an extremely important international research resource. The high demand for CGC strains reflects their great importance to the research community; currently more than 25,000 strains are distributed per year. The CGC curates C. elegans strains and distributes them upon request through an on-line ordering system. A new research component will be implemented to expand the activities of the CGC. The C. elegans genetic tool-kit will be enhanced through the generation of genetic tools to aid researchers in manipulations of lethal and sterile mutations.

秀丽隐杆线虫遗传学中心 (CGC) 的总体目标是通过获取、维持和分发具有遗传特征的线虫种群，促进对小型后生动物秀丽隐杆线虫的研究。世界各地的研究人员在各种基础和应用研究工作中使用从 CGC 获得的遗传资源。使用这种首要模型生物体进行的研究使人们对基本生物学机制有了基本的了解，包括程序性细胞死亡的遗传基础、microRNA 的发现以及动物 RNA 干扰的机制。事实证明，线虫对于理解癌症进展和其他疾病（包括阿尔茨海默氏症和帕金森氏症）的机制以及揭示人类发育的基本机制也很重要。此外，线虫是阐明我们对与人类和牲畜健康相关的寄生线虫的理解的关键模型。作为线虫线虫的唯一总资源中心，CGC 是极其重要的国际研究资源。对 CGC 菌株的高需求反映了它们对研究界的重要性；目前每年分发超过25,000株菌株。 CGC 精选秀丽隐杆线虫菌株，并根据要求通过在线订购系统进行分发。将实施新的研究部分以扩大 CGC 的活动。线虫遗传工具包将通过遗传工具的生成得到增强，以帮助研究人员操纵致命和不育突变。