2022 Midwest Platelet Conference

2022年中西部血小板会议

• 批准号: 10536072
• 负责人: MICHAEL Allan HOLINSTAT
• 金额: $ 1万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10536072
• 关键词: Address; Adhesions; Adhesives; Affinity; Atherosclerosis; Basic Science; Binding; Biochemistry; Biological Process; Biology; Biotechnology; Blood; Blood Platelet Disorders; Blood Platelets; Blood Vessels; Blood coagulation; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Charge; Clinic; Clinical; Clinical Research; Clinical Treatment; Clinical Trials; Collaborations; Collagen; Communication; Data; Defect; Development; Diabetes Mellitus; Discipline; Disease; Diverse Workforce; Endothelial Cells; Ensure; Environment; Faculty; Feedback; Fees; Fibrinolysis; Fostering; Functional disorder; Future; Goals; Health; Hemostatic Agents; Hemostatic function; Immune; Immunity; Individual; Infection; Inflammation; Injury; Life; Malignant Neoplasms; Midwestern United States; Morbidity - disease rate; Myocardial Infarction; Names; National Heart, Lung, and Blood Institute; Obesity; Oral; Pathologic; Pathology; Pathway interactions; Patients; Pharmacologic Substance; Physiological; Plant Roots; Play; Poaceae; Postdoctoral Fellow; Prevention; Property; Regulation; Research; Research Personnel; Role; Science; Scientist; Series; Signal Transduction; Stroke; Surface; Therapeutic Intervention; Thrombosis; Time; Training; Translating; Translational Research; Translations; Trauma; Travel; Underrepresented Minority; United States National Institutes of Health; Vascular Endothelial Cell; Venous Thrombosis; Woman; angiogenesis; clinical development; cost; disorder prevention; drug development; experience; faculty support; graduate student; immunoregulation; innovation; meetings; mortality; nervous system disorder; new technology; new therapeutic target; next generation; novel; novel strategies; novel therapeutics; physically handicapped; platelet function; posters; prevent; programs; symposium; trend; tumor progression; undergraduate student; wound healing

The Midwest Platelet Conference will be held in Ann Arbor, MI, September 29th - October 30th. This is the 18th meeting in a series established to showcase the most innovative science in platelet biology in the basic, clinical, and translational forefronts of the field and support the trainees and young investigators as they develop their science in the field of platelets, hemostasis, and thrombosis. The Midwest Platelet Conference (MPC) was established 38 years ago to promote interactions between established investigators and trainees studying platelets, vascular biology, thrombosis and hemostasis. This conference is closely aligned with the goals of the NIH and NHLBI to understand how the platelet functions and its role in arterial and venous thrombosis, hemostasis, immune-thrombotic diseases, and inflammation in order to develop better approaches to treating these pathological conditions. Platelets play an essential role in maintaining hemostasis. Under normal physiological conditions, platelets circulate and have no affinity for vascular endothelial cells that cover the surface of blood vessels. However, upon injury to blood endothelial cells, platelets bind with high affinity to the collagen exposed in the underlying sub-endothelial matrix. This interaction also leads to other adhesive interactions that result in the activation of other platelets and their binding with each other to form an aggregate. In addition to their essential function in the hemostatic pathway, platelets also secrete >300 bioactive molecules, which have a range of other properties that are essential for modulation of key biological processes including fibrinolysis, wound repair, proliferation, angiogenesis and inflammation, just to name a few. These biological processes are tightly regulated by a crosstalk between platelets and vessel wall endothelial cells. A defect in the interactions/communications between platelets and endothelial cells can compromise the integrity of blood vessels culminating in cardiovascular disease (CVD) including heart attacks and strokes, which are the leading causes of death in the US. This conference is an essential grassroots forum for trainees and junior investigators to present their findings, receive critical feedback on their studies and network with trainees and faculty from around the US. To this end, there is an emphasis on presentation of unpublished data to ensure the presentation of cutting edge research in many fields focused in blood clotting and platelets. In line with the focus of the NIH and NHLBI, there is a focus on inclusion of women, underrepresented minorities, and young investigators in the conference including undergraduates, graduate students, postdoctoral fellows, clinical fellows, junior faculty, and individuals with physical disabilities. The conference will include oral presentation slots for trainees in each of 6 session as well as 50 poster discussions in a dedicated session. The oral sessions will focus on topics including: New technologies in platelet research, Platelet biochemistry and signaling, Platelet disorders in the clinic, Platelet adhesion, aggregation, and secretion, New advances in antiplatelet therapy in translational research, and Emerging trends in platelet research. The goal of the Midwest Platelet Conference is to bring together leading experts and trainees in order to foster free exchange of ideas that will lead to advances in preventing or treating life-threatening diseases caused by dysregulation of platelet activity.

中西部血小板会议将于9月29日至10月30日在密歇根州安阿伯举行。这是第18次会议 建立的系列旨在展示基本，临床和翻译中血小板生物学上最具创新性的科学 该领域的前沿，并支持受训人员和年轻的调查员在该领域发展科学 血小板，止血和血栓形成。中西部血小板会议（MPC）成立于38年前，以促进 研究人员和研究血小板，血管生物学，血栓形成和研究人员之间的相互作用 止血。这次会议与NIH和NHLBI的目标密切相符，以了解血小板如何 功能及其在动脉和静脉血栓形成，止血，免疫栓性疾病和炎症中的作用 为了开发更好的治疗这些病理状况的方法。血小板在 保持止血。在正常的生理条件下，血小板循环，对血管无亲和力 覆盖血管表面的内皮细胞。但是，在血液内皮细胞受伤后，血小板结合 与在基础底皮基质中暴露的胶原蛋白的亲和力高。这种互动也导致其他 导致其他血小板激活及其彼此结合以形成聚集体的粘合性相互作用。 除了它们在止血途径中的基本功能外，血小板还分泌> 300个生物活性分子，其中 具有一系列其他特性，这些特性对于调节关键生物学过程至关重要，包括纤维蛋白溶解， 伤口修复，增殖，血管生成和炎症，仅举几例。这些生物过程紧密 由血小板和血管壁内皮细胞之间的串扰调节。互动/通信中的缺陷 血小板和内皮细胞之间会损害血管的完整性 疾病（CVD），包括心脏病发作和中风，这是美国死亡的主要原因。这次会议是 一个基本的基层论坛，适用于学员和初级调查人员，以介绍他们的发现，收到关键反馈 在他们的学习和与来自美国各地的受训者和教职员工的网络上。为此，强调 呈现未发表的数据，以确保在许多领域的尖端研究中提出尖端研究 凝结和血小板。符合NIH和NHLBI的重点，重点是纳入女性 会议中代表不足的少数民族和年轻调查员，包括本科生，研究生， 博士后研究员，临床研究员，初级教职员工和身体残障人士。会议将 在6个会话中的每一个中都会为受训者提供口头演示插槽，并在专门的会议中进行50个海报讨论。 口腔会议将重点介绍：血小板研究，血小板生物化学和 信号传导，诊所中的血小板疾病，血小板粘附，聚集和分泌，抗血小板的新进展 翻译研究中的治疗以及血小板研究的新兴趋势。中西部血小板的目标 会议是将领先的专家和学员汇集 在预防或治疗由于血小板活性失调引起的预防或治疗威胁生命的疾病。