Examining Neural Modulatory Effects of Serotonergic Psychedelic Compounds in Relation to Neuroticism

检查血清素迷幻化合物与神经质相关的神经调节作用

基本信息

批准号：
10535571
负责人：
Brandon Weiss
金额：
$ 5.27万
依托单位：
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-11-01 至 2023-07-26
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10535571
关键词：
Acute Agonist Amygdaloid structure Animal Model Animals Binding Bolus Infusion Brain Brain region Clip DSM-V Dose Fellowship Functional Magnetic Resonance Imaging Future Goals Hallucinogens Hippocampus (Brain)Human Infusion procedures Intervention Link Literature Magnetic Resonance Imaging Mental Health Mental disorders Methods Modeling Molecular Neurobiology Neuronal Plasticity Neurophysiology - biologic function Neurotic Disorders Outcome Patient Self-Report Pattern Personality Personality Traits Personality inventories Physiological Positron-Emission Tomography Prefrontal Cortex Process Psychopathology Research Research Personnel Role Stress Structure Synapses Synaptic plasticity Therapeutic Effect Time blood oxygen level dependent density first-in-human indexing movie negative affect physical conditioning psychologic radioligand receptor relating to nervous system trait

项目摘要

PROJECT SUMMARY/ABSTRACT Serotonergic 2A receptor agonists (“classic psychedelics”) have recently been described as psychoplastogens in view of their selective modulatory effects on neural structure and function. Although this neural modulatory mechanism has been well demonstrated in animal models, researchers are only now examining its role in the living human brain. Understanding processes involving selective and adaptive modulation of neural structure may in the future catalyze important interventions into mental and physical health that harness the brain’s capacity for plasticity. The present proposal leverages a comprehensive set of methods at molecular, functional, and psychological levels of analysis to investigate whether and how psychedelic compounds produce neural plasticity, and whether neural modulatory processes underlie post- acute changes in functional activation and synchrony in regions related to the personality trait neuroticism and adaptive post-acute effects on neuroticism found in the literature. The long-term goal of this line of research is to understand processes underlying selective modulation of neural structure and function. The overall objective is to ascertain whether psychedelic compounds produce neural plasticity indexed by Positron Emission Tomography radioligand indices of synaptic density and functional Magnetic Resonance Imaging activation and synchrony, and whether these changes covary with adaptive changes in neuroticism.

项目摘要/摘要血清素能2A受体激动剂（“经典迷幻药”）最近被描述为鉴于其选择性调节作用对神经结构和功能的选择性作用。尽管这种神经调节机制在动物模型中得到了很好的证明，但研究人员直到现在才研究其在活着的人脑中的作用。了解过程涉及神经元结构的选择性和适应性调制可能会在将来催化对精神和身体健康的重要干预，可以利用大脑的能力可塑性。本提案利用分子上的一组综合方法，功能和心理分析水平，以调查是否以及如何迷幻化合物产生神经可塑性，以及神经调节过程是否是在与人格特征有关的地区功能激活和同步的急性变化神经质和适应性后急性后对文献中发现的神经质作用。长期这一研究的目标是了解神经选择性调制的过程结构和功能。总体目标是确定迷幻化合物是否通过正电子发射断层扫描放射性索引产生神经可塑性索引突触密度和功能磁共振成像激活和同步，以及这些变化是否随着神经质的自适应变化而变化。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Prevalence and therapeutic impact of adverse life event reexperiencing under ceremonial ayahuasca.

DOI：
10.1038/s41598-023-36184-3
发表时间：
2023-06-09
期刊：
Scientific reports
影响因子：
4.6
作者：
通讯作者：

A critical evaluation of QIDS-SR-16 using data from a trial of psilocybin therapy versus escitalopram treatment for depression.

DOI：
10.1177/02698811231167848
发表时间：
2023-07
期刊：
JOURNAL OF PSYCHOPHARMACOLOGY
影响因子：
4.1
作者：
Weiss, Brandon;Erritzoe, David;Giribaldi, Bruna;Nutt, David J.;Carhart-Harris, Robin L.
通讯作者：
Carhart-Harris, Robin L.

Examining the Therapeutic Effect of Ceremonial Ayahuasca on Narcissistic Personality and Antagonistic Externalizing in Adults.