Development of a Personalized Intervention to Motivate Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease

制定个性化干预措施以激励有阿尔茨海默病风险的中年成年人改变健康行为

• 批准号: 10524271
• 负责人: JENNIFER D DAVIS
• 金额: $ 21.74万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10524271
• 关键词: Address; Adherence; Adult; Age; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Behavior; Behavioral Model; Belief; Cognition; Cognitive; Communities; Cues; Data; Dementia; Development; Diet; Discipline; Disease; Distal; Education; Educational Intervention; Elderly; Ensure; Focus Groups; Future; Goals; Grant; Health behavior; Health behavior change; Health education; Impaired cognition; Individual; Infrastructure; Intervention; Interview; Knowledge; Life Style; Life Style Modification; Mediator of activation protein; Methods; Modeling; Monitor; Motivation; Outcome; Participant; Persons; Physical activity; Play; Population; Prevention; Prevention trial; Protocols documentation; Psyche structure; Qualitative Methods; Randomized; Registries; Reporting; Research; Rhode Island; Risk; Risk Factors; Role; Science; Self Efficacy; Stress; Time; United States National Institutes of Health; Work; base; behavior change; cohort; dementia risk; depressive symptoms; efficacy study; evidence base; good diet; health assessment; health belief; improved; insight; lifestyle intervention; middle age; modifiable risk; motivated behavior; patient engagement; personalized intervention; pilot trial; prevent; programs; recruit; risk perception; self-reported depression; stress reduction; tailored messaging; theories; therapy development; Address; Adherence; Adult; Age; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Behavior; Behavioral Model; Belief; Cognition; Cognitive; Communities; Cues; Data; Dementia; Development; Diet; Discipline; Disease; Distal; Education; Educational Intervention; Elderly; Ensure; Focus Groups; Future; Goals; Grant; Health behavior; Health behavior change; Health education; Impaired cognition; Individual; Infrastructure; Intervention; Interview; Knowledge; Life Style; Life Style Modification; Mediator of activation protein; Methods; Modeling; Monitor; Motivation; Outcome; Participant; Persons; Physical activity; Play; Population; Prevention; Prevention trial; Protocols documentation; Psyche structure; Qualitative Methods; Randomized; Registries; Reporting; Research; Rhode Island; Risk; Risk Factors; Role; Science; Self Efficacy; Stress; Time; United States National Institutes of Health; Work; base; behavior change; cohort; dementia risk; depressive symptoms; efficacy study; evidence base; good diet; health assessment; health belief; improved; insight; lifestyle intervention; middle age; modifiable risk; motivated behavior; patient engagement; personalized intervention; pilot trial; prevent; programs; recruit; risk perception; self-reported depression; stress reduction; tailored messaging; theories; therapy development

PROJECT ABSTRACT Modifiable risk factors such as physical activity, healthy diet, stress reduction, and cognitive stimulation are associated with lower risk of Alzheimer’s disease (AD) and related dementias. Population-level engagement in positive health behaviors in midlife and early late life is low, and large, multi-domain prevention trials have reported a positive impact of lifestyle modification on risk for cognitive decline. However, adherence to trial protocols is poor despite intensive individualized coaching, raising concern about generalizability and the ability to motivate sustained behavior change. The objective of this Stage I intervention development project is to use the science of behavior change to develop a theoretically grounded, personalized health education intervention that will motivate sustained health behavior change to prevent or delay the onset of Alzheimer’s disease (AD). The intervention will be grounded in the Health Belief Model, a widely-used conceptual framework that posits that health beliefs including perceived threat of disease, perceived benefits and barriers, and self-efficacy (belief in one’s ability to change) are mediators of behavior change. The proposed project will enhance our existing 12-session basic healthy living education program to include evidence-based assessment of health belief factors and personalized education about the role these factors play in motivating and sustaining behavior change. We will use qualitative methods to develop an explanatory method for communicating personal health beliefs (Aim 1) and conduct a randomized controlled pilot trial to assess feasibility and the effect of the enhanced intervention versus basic health education alone on proximal outcomes including AD risk perception, self-efficacy, and AD risk knowledge (Aim 2). Results will motivate future efficacy studies investigating the impact of the enhanced healthy living education intervention on distal outcomes, including engagement in positive health behaviors, lower AD risk, and prevention of cognitive decline.

项目摘要 可修改的危险因素，例如体育活动，健康饮食，减轻压力和认知刺激是 与阿尔茨海默氏病（AD）和相关痴呆症的较低风险有关。人口级参与 中年和后期的积极健康行为较低，大型多域预防试验具有 报道了生活方式改变对认知能力下降的风险的积极影响。但是，遵守审判 协议是剂量较差的强化个性化教练，引起了人们对概括性和能力的关注 融合持续的行为改变。 I阶段I干预开发项目的目的是使用 行为科学改变以发展理论基础，个性化的健康教育干预措施 这将激发持续的健康行为改变，以防止或延迟阿尔茨海默氏病（AD）的发作。 干预措施将基于健康信念模型，这是一个广泛使用的概念框架 健康认为包括对疾病的威胁，感知的福利和障碍以及自我效力 （相信一个人的能力）是行为改变的调解人。拟议的项目将增强我们的 现有的12条基本健康生活教育计划，包括基于证据的健康评估 相信这些因素在激励和维持中起作用的因素和个性化教育 行为改变。我们将使用定性方法来开发一种传播方法来进行交流 个人健康信念（AIM 1）并进行随机对照试验试验，以评估可行性和 增加干预与基本健康教育对近端结果在内的影响（包括广告）的影响 风险感知，自我效能和AD风险知识（AIM 2）。结果将激励未来的效率研究 调查增强健康生活教育干预对远端结果的影响，包括 参与积极的健康行为，降低AD风险以及预防认知能力下降。