Functional and Radiomic Magnetic Resonance Profiling in Normal and Hypertensive Placentas

正常和高血压胎盘的功能和放射磁共振分析

• 批准号: 10525117
• 负责人: Christina Lynn Herrera
• 金额: $ 14.07万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-02 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10525117
• 关键词: Address; Affect; Area; Arteries; Award; Basic Science; Biological Markers; Blood Vessels; Characteristics; Chronic; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Data; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Doppler Ultrasound; Early identification; Fetal Growth Retardation; Fetal health; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Grant; Growth; Heterogeneity; Human; Hypertension; Image; Interdisciplinary Study; Intervention; K-Series Research Career Programs; Knowledge; Magnetic Resonance; Magnetic Resonance Imaging; Manuals; Maps; Maternal Health; Measurement; Measures; Mediating; Mentors; Motion; Outcome; Pathologic; Pathology; Pattern; Peer Review; Perfusion; Placenta; Placenta Diseases; Placentation; Populations at Risk; Pre-Eclampsia; Pregnancy; Pregnant Women; Process; Publications; Reproducibility; Reproducibility of Results; Research; Research Personnel; Resistance; Risk; Role; Second Pregnancy Trimester; Spiral Artery of the Endometrium; Standardization; T2 weighted imaging; Technical Expertise; Techniques; Technology; Testing; Texture; Time; Translational Research; Uterus; Woman; Work; arterial spin labeling; automated segmentation; base; blood oxygen level dependent; career; clinical investigation; cohort; contrast imaging; deep learning; faculty mentor; hypertensive; hypoperfusion; imaging Segmentation; imaging modality; improved; in vivo; insight; interest; non-invasive imaging; novel; predictive modeling; pregnant; prenatal exposure; prospective; protein biomarkers; radiomics; skills; ultrasound

PROJECT SUMMARY One in 3 pregnant women with chronic hypertension (CHTN) deliver preterm from complications of superimposed preeclampsia or fetal growth restriction (FGR). The specific aims are: 1) prospectively evaluate the placental longitudinally via functional magnetic resonance imaging (MRI) in healthy pregnant women and pregnant women with CHTN; 2) extract radiomics texture features in normal and hypertensive placentas and 3) execute technical refinement toward automated segmentation for regions of interest to delineate patterns in placental abnormalities. We will study 20 normal pregnant women and 40 pregnant women with CHTN across gestation. MRI will be performed in the early and late second trimester to assess perfusion via arterial spin labeling (ASL), diffusion via intra-voxel incoherent motion (IVIM) diffusion weighted imaging (DWI) and DWI- derived apparent diffusion coefficient (ADC) mapping, and oxygenation via T2* from blood-oxygen level dependent (BOLD) MRI. Radiomics texture features also be extracted from MR imaging and automated segmentation applied for more subjective placental assessment. This career development award will establish Dr. Herrera as a clinical investigator focused on non-invasive imaging assessment of placental development and dysfunction. The award will provide her with the support needed to develop expertise in 3 areas: 1) clinical research 2) application and interpretation of advanced imaging modalities, and 3) technical skills of post- processing and deep learning. To achieve these goals, Dr. Herrera has assembled an interdisciplinary team with expertise in clinical investigation, placental imaging, and post-processing and automated segmentation techniques. Her primary mentor, Dr. Catherine Spong, has a long track record of successful clinical, translational, and basic science research including over 270 peer review publications and mentoring faculty to become independent investigators. The focus of this proposal is on the human placenta. Despite 150+ years of placental research, the role of the placenta in the pathology of pregnancy-related disease remains poorly understood. Understanding normal placental development and changes present in placental disease will provide a foundation to facilitate clinical prediction of pathologic conditions during pregnancy and provide an opportunity to test interventions. In this study, we will address the unmet clinical need to characterize both normal placental development and placental dysfunction in vivo. We have chosen to compare normal pregnant women with pregnant women with chronic hypertension as these women are increased risk for placental- mediated disease. Successful completion of this project will allow for better understanding of the placenta in normal pregnancy and pregnancy affected by chronic hypertension. We will also correlate our results with clinical outcomes of preeclampsia and FGR. Given the increased risk of superimposed preeclampsia and FGR in pregnant women with chronic hypertension, we anticipate from these results additional insights and novel hypotheses regarding potential radiomic biomarkers for the prediction of preeclampsia and FGR.

项目摘要 三分之一的患有慢性高血压（CHTN）的孕妇从并发症中分娩了早产 叠加的先兆子痫或胎儿生长限制（FGR）。具体目的是：1）前瞻性评估 健康孕妇和 患有CHTN的孕妇； 2）提取正常和高血压胎盘中的放射组学纹理特征以及3） 执行对自动细分的技术精炼 胎盘异常。我们将研究20名正常孕妇和40名CHTN的孕妇 妊娠。 MRI将在第二学期和晚期进行通过动脉自旋评估灌注 标记（ASL），通过体内内部不相互运动（IVIM）扩散加权成像（DWI）和DWI-的扩散 得出的表观扩散系数（ADC）映射，通过T2*从血氧水平进行氧合 依赖（粗体）MRI。也从MR成像和自动化中提取放射线纹理特征 细分适用于更主观的胎盘评估。这个职业发展奖将建立 Herrera博士作为临床研究者，重点介绍胎盘发育的非侵入性成像评估 和功能障碍。该奖项将为她提供在3个领域发展专业知识所需的支持：1）临床 研究2）应用和解释高级成像方式，以及3）后的技术技能 - 处理和深度学习。为了实现这些目标，埃雷拉博士召集了一个跨学科团队 具有临床研究，胎盘成像以及后处理和自动分割方面的专业知识 技术。她的主要导师凯瑟琳·斯波（Catherine Spong）博士在成功的临床上有很长的记录， 翻译和基础科学研究，包括270多个同行评审出版物和指导教师 成为独立的调查员。该提议的重点放在人体胎盘上。尽管有150年以上 胎盘研究，胎盘在妊娠相关疾病的病理中的作用仍然很差 理解。了解正常的胎盘发育和胎盘疾病中存在的变化将 为怀孕期间病理状况的临床预测提供基础 测试干预措施的机会。在这项研究中，我们将解决未满足的临床需求，以表征 正常的胎盘发育和体内胎盘功能障碍。我们选择比较正常怀孕 患有慢性高血压孕妇的妇女由于这些妇女的胎盘风险增加 - 介导的疾病。成功完成该项目将使您可以更好地了解胎盘 正常怀孕和怀孕受慢性高血压影响。我们还将将我们的结果与 先兆子痫和FGR的临床结果。鉴于叠加先兆子痫和FGR的风险增加 在患有慢性高血压的孕妇中，我们可以从这些结果中预期更多的见解和新颖的见解 关于预测先兆子痫和FGR的潜在放射性生物标志物的假设。