Cancer Invasion and Metastasis

癌症侵袭和转移

基本信息

批准号：
10650408
负责人：
Andrew Josef Ewald
金额：
$ 5.43万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-05-07 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10650408
关键词：
3-Dimensional Address Adhesions Aging Animal Model Area Automobile Driving Biology Biomedical Engineering Biophysics Cancer Biology Cancer Patient Catchment Area Cell physiology Cells Clinic Clinical Clinical Trials Collaborations Colon Carcinoma Complex Comprehensive Cancer Center Cytometry Disease Disparity Distant Metastasis Doctor of Medicine Doctor of Philosophy Drug Targeting Early Diagnosis Engineering Epithelium Faculty Funding Gene Expression Genes Genetic Screening Genetically Engineered Mouse Genomics Goals Grant Head and neck structure Image Immune Individual Interdisciplinary Study Invaded Journals Lead Malignant Neoplasms Malignant neoplasm of prostate Manuscripts Mass Spectrum Analysis Mechanics Metastatic Prostate Cancer Modeling Molecular National Cancer Institute Neoplasm Circulating Cells Neoplasm Metastasis Oncology Organ Organism Organoids Outcome Patient-Focused Outcomes Patients Peer Review Physiological Process Productivity Prostate Public Health Schools Publications Radiation Radiation Dose Unit Recurrence Recurrent Malignant Neoplasm Recurrent disease Regulation Research Research Personnel Resistance Resource Sharing Schools Scientist Services Site Skin Stress System Techniques Therapeutic Tissues Toxic effect Training Translating United States National Institutes of Health Universities Upper aerodigestive tract cancer Work anticancer treatment cancer cell cancer recurrence cell behavior cell motility design insight malignant breast neoplasm medical schools melanoma member men migration molecular imaging mortality mouse model multiple omics neoplastic cell novel patient derived xenograft model peer physical science programs real-time images reconstruction single cell sequencing skills success technology development three dimensional cell culture tool translational physician tumor tumor microenvironment tumor progression

项目摘要

PROJECT SUMMARY/ABSTRACT The Cancer Invasion and Metastasis Program (CIM) is a new Program within the Sidney Kimmel Comprehensive Cancer Center (SKCCC). CIM was launched to elucidate and target the mechanisms driving metastasis, as metastasis is the major driver of patient outcomes. The Program consists of highly accomplished basic scientists working collaboratively with engineers and translational physician-scientists. The Co-Leaders are Andrew Ewald, Ph.D. (basic, invasion focused); Ashani Weeraratna, Ph.D. (basic, tumor microenvironment focused); and Phuoc Tran, M.D., Ph.D (basic/clinical, recurrent disease focused). CIM is comprised of 42 Members (31 Full Members and eleven Associate Members) from three schools and 16 departments at Johns Hopkins University. Faculty are affiliated with four T-32 training grants across the School of Medicine, School of Public Health, and School of Engineering. The total direct cancer-relevant peer- reviewed funding is $14.1 million, with $8.3 million from the National Cancer Institute. The total number of publications by Program members is 768, of which 129 (16.8%) are Intra-Programmatic, 412 (53.8%) are Inter- Programmatic and 487 (63.4%) have external collaborations. Of these publications, 20.6% are in journals with impact factors >10 and 5.7% in journals with impact factors >25. The Aims of the Program are: Aim 1: To elucidate the molecular and cellular mechanisms regulating individual and collective cancer cell motility and invasion across organ sites using cutting-edge models and tools. Aim 2: To define the regulation of cancer function by the cellular, molecular and mechanical features of the tumor microenvironment. Investigators target and disrupt the crosstalk between the cancer cell and the metastasis-promoting microenvironment using physiologically relevant models (e.g., organoids, 3D skin reconstruction, cell-derived matrices, humanized animal models). Aim 3: To determine and disrupt the underlying cause of recurrent cancer at the cellular and molecular level by targeting barriers to therapeutic success in cancer, including therapy resistance, tumor dormancy and recurrent disease. Research success across these aims is critically enabled by SKCCC Shared Resources (Oncology Tissue and Imaging Services, Experimental and Computational Genomics, Flow/Mass Cytometry and Technology Development, and Mass Spectrometry Molecular Imaging and Multi-Omics). Program members lead a P01 grant to understand microenvironmental regulation of therapy resistance and metastasis in melanoma, and a U54 that integrates physical science and translational perspectives to understand cancer invasion. Members also participate in three SPOREs (Prostate, GI, Head and Neck) and six MPI U01 grants.

项目概要/摘要癌症侵袭和转移计划 (CIM) 是 Sidney Kimmel 的一项新计划综合癌症中心（SKCCC）。 CIM 的推出是为了阐明和瞄准驱动机制转移，因为转移是患者结果的主要驱动因素。该计划包括高度成就卓著的基础科学家与工程师和转化医学科学家合作。这联合领导者是 Andrew Ewald 博士。（基本，以入侵为重点）；阿沙尼·维拉拉特纳博士（基础、肿瘤重点关注微环境）；和 Phuoc Tran，医学博士、哲学博士（基础/临床，重点关注复发性疾病）。 CIM 是由来自三所学校的 42 名会员（31 名正式会员和 11 名准会员）和 16 名会员组成约翰霍普金斯大学的系。学院内的教师均隶属四项 T-32 培训补助金医学院、公共卫生学院和工程学院。与癌症直接相关的同行总数审查资金为 1410 万美元，其中 830 万美元来自国家癌症研究所。总数计划成员发表的出版物为 768 篇，其中 129 篇 (16.8%) 为计划内出版物，412 篇 (53.8%) 为计划间出版物程序化和 487 个（63.4%）有外部合作。在这些出版物中，20.6% 发表在以下期刊上：影响因子 >10 的期刊和影响因子 >25 的期刊为 5.7%。该计划的目标是：目标 1：阐明调节个体和集体癌细胞运动的分子和细胞机制使用尖端模型和工具入侵器官部位。目标 2：明确癌症的监管其功能受肿瘤微环境的细胞、分子和机械特征的影响。调查人员的目标并破坏癌细胞和促进转移的微环境之间的串扰生理相关模型（例如类器官、3D 皮肤重建、细胞衍生基质、人源化模型）动物模型）。目标 3：确定并破坏细胞和细胞层面癌症复发的根本原因。分子水平，针对癌症治疗成功的障碍，包括治疗耐药性、肿瘤休眠和疾病复发。 SKCCC 共享对这些目标的研究成功至关重要资源（肿瘤组织和成像服务、实验和计算基因组学、流量/质量细胞计数和技术开发、质谱分析、分子成像和多组学）。计划成员领导 P01 拨款，以了解治疗抵抗的微环境调节和黑色素瘤的转移，以及结合物理科学和转化观点的 U54 了解癌症的侵袭。会员还参加三个 SPORE（前列腺、胃肠道、头颈）和六个 SPORE MPI U01 补助金。