VISION RESEARCH CORE GRANT

愿景研究核心资助

• 批准号: 10650722
• 负责人: W MARTIN USREY
• 金额: $ 78.5万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10650722
• 关键词: Animals; Applications Grants; California; Clinical; Collaborations; Collection; Communities; Core Facility; Core Grant; Custom; Data; Discipline; Disease; Eligibility Determination; Environment; Faculty; Fostering; Funding; Goals; Grant; Growth; Health; Home; Human Resources; Individual; Institution; Laboratories; Microscopy; Molecular; Play; Postdoctoral Fellow; Principal Investigator; Productivity; Research; Research Personnel; Resource Sharing; Resources; Role; Scientist; Services; Software Engineering; Structure; Talents; Technical Expertise; Training Programs; Translational Research; Universities; Vision; Vision research; Visual System; Work; cohort; cost; cost efficient; design; innovation; multidisciplinary; ocular imaging; recruit; skills; student training; tissue processing; tool; vision science

SUMMARY – OVERALL This application seeks five years of continued support for an NEI Core Grant that has facilitated the research efforts of vision scientists at the University of California, Davis for the past 20 years. The goal is to enhance vision science by providing cost-efficient, stable, and shared resources that are not generally available to individual laboratories. It will enhance collaborations and translational research among a large group of 35 funded vision scientists at UC Davis who hold 20 Core-eligible NEI R01 grants. It will also facilitate collection of preliminary data for new grant applications by funded and yet-to-be-funded UC Davis laboratories, and sharing of resources developed for UC Davis with the vision science community outside of our institution. Building on our strengths and new directions in the field, we have redesigned the currently funded cores to better serve the needs of our NEI investigators. The proposed Cores are: (i) Software Engineering, (ii) Molecular Construct and Packaging, (iii) Microscopy and Tissue Processing, (iv) Small Animal Ocular Imaging, and (v) Large Animal. Each Core Director has one or more NEI R01 grants, and is supported by talented and skilled technical staff. These five Cores provide custom facilities and personnel that serve the needs of our NEI investigators and their trainees. The administrative structure includes an Executive Committee, comprising the Principal Investigator and the Core Directors, along with regular input from all vision scientists on campus, and a distinguished group of External Advisors. Priorities for use of core facilities have been carefully honed and made available to all investigators. The administration of UC Davis has been and continues to be exceptionally supportive of vision research on campus. This is demonstrated by a substantial increase in the number of vision scientists recruited to the university, with a commensurate increase in NEI-funded grants. This growth is further buttressed by institutional support in the form of seed grants to stimulate new research in vision science, the planned recruitment of new faculty in vision science, and funding for the Center for Vision Science, which provides a means for unifying our community of vision researchers and fostering collaborations with an accomplished cohort of biologists on campus and vision scientists at other institutions.

摘要 - 总体 该申请寻求五年的继续支持NEI核心赠款，该资助已准备好研究 在过去的20年中，加利福尼亚大学戴维斯分校的视觉科学家的努力。目标是增强 通过提供成本效益，稳定和共享的资源，视觉科学通常不可用 个别实验室。它将增强合作和翻译研究的研究 加州大学戴维斯分校的愿景科学家资助的科学家持有20个核心资格的NEI R01补助金。它也将有助于收集 通过资助和尚未资助的UC Davis实验室的新赠款申请的初步数据，并共享 为加州大学戴维斯分校开发的资源与我们机构之外的视觉科学界开发。建立 我们在该领域的优势和新方向，我们重新设计了当前资助的核心，以更好地服务 我们的NEI调查人员的需求。提出的核心是：（i）软件工程，（ii）分子结构和 包装，（iii）显微镜和组织加工，（iv）小动物眼成像和（v）大动物。 每个核心主任都有一个或多个NEI R01赠款，并得到才华横溢和熟练的技术人员的支持。 这五个核心提供了定制的设施和人员，可满足我们的NEI调查人员的需求 学员。行政结构包括一个执行委员会，完成了首席调查员 以及核心主管，以及校园中所有视觉科学家的定期投入，以及一个杰出的团体 外部顾问。使用核心设施的优先事项已经过仔细的荣誉，并提供给所有人 调查人员。加州大学戴维斯分校的管理一直并继续受到远见的极为支持 校园的研究。这是通过招募的视力科学家数量的大幅增加来证明的 到大学，由Nei资助的赠款提高。这种增长进一步支持 以种子赠款形式的机构支持，以刺激视力科学中的新研究 招募视觉科学领域的新教师，并为视觉科学中心提供资金，该中心提供了一个 用于统一我们的视觉研究人员社区，并与成就的队列促进合作 其他机构的校园和视力科学家的生物学家。

项目成果

Involvement of YAP, TAZ and HSP90 in contact guidance and intercellular junction formation in corneal epithelial cells.

• DOI: 10.1371/journal.pone.0109811
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Raghunathan VK;Dreier B;Morgan JT;Tuyen BC;Rose BW;Reilly CM;Russell P;Murphy CJ
• 通讯作者: Murphy CJ

Bright flash response recovery of mammalian rods in vivo is rate limited by RGS9.

• DOI: 10.1085/jgp.201611692
• 发表时间: 2017-04-03
• 期刊: The Journal of general physiology
• 作者: Peinado Allina G;Fortenbach C;Naarendorp F;Gross OP;Pugh EN Jr;Burns ME
• 通讯作者: Burns ME

The Use of Electrotherapeutics in Ophthalmology.

• DOI: 10.1016/j.ajo.2019.11.011
• 发表时间: 2020-03
• 期刊: American journal of ophthalmology
• 影响因子: 4.2
• 作者: Luu KY;Zhao M;Mannis MJ
• 通讯作者: Mannis MJ

Inhibition of adult rat retinal ganglion cells by D1-type dopamine receptor activation.

• DOI: 10.1523/jneurosci.3827-09.2009
• 发表时间: 2009-11-25
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Hayashida Y;Rodríguez CV;Ogata G;Partida GJ;Oi H;Stradleigh TW;Lee SC;Colado AF;Ishida AT
• 通讯作者: Ishida AT

The responses of VIP neurons are sufficiently sensitive to support heading judgments.

• DOI: 10.1152/jn.00401.2009
• 发表时间: 2010-02
• 期刊: Journal of neurophysiology
• 影响因子: 2.5
• 作者: Tao Zhang;K. H. Britten