Pilot Resarch

试点研究

• 批准号: 10649606
• 负责人: Elena V Romanova
• 金额: $ 11.55万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-23 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10649606
• 关键词: Address; Advisory Committees; Affect; Area; Award; Behavioral; Bioinformatics; Categories; Chemicals; Collaborations; Communication; Communities; Data; Data Analytics; Dimensions; Drug usage; Effectiveness; Electronic Mail; Ensure; Evaluation; Feasibility Studies; Feedback; Follow-Up Studies; Fostering; Funding; Future; Goals; Illinois; Individual; Informatics; International; Lead; Mass Spectrum Analysis; Measurement; Methodology; Molecular; Molecular Profiling; National Institute of Drug Abuse; Neuronal Plasticity; Neuropeptides; Neurosciences; Neurotransmitters; Notification; Outcome; Outcomes Research; Phenotype; Physiological; Pilot Projects; Process; Proteins; Qualifying; Reporting; Research; Research Personnel; Research Project Grants; Resolution; Resources; Route; Sampling; Scientific Evaluation; Scientist; Secure; Services; Social Environment; Societies; Staff Development; Substance abuse problem; Technology; Work; Writing; addiction; base; career; follow-up; high risk; improved; innovation; insight; intercellular communication; interest; meetings; neuroproteomics; predictive modeling; programs; prospective; recruit; social influence; success; transmission process; web site

The Pilot Research Project Core solicits, evaluates and supports new and innovative feasibility studies for the UIUC Neuroproteomics and Neurometabolomics Center on Cell-Cell Signaling. Our Core (and Center) are successful when we foster the success of promising young investigators new to either our `omics measurement capabilities or to addiction research, and we also encourage established researchers to explore new directions in addiction research. The selected pilot projects will have access to our considerable Center resources available through our scientific cores—Sampling and Separation, Molecular Profiling and Characterization, and Bioinformatics, Data Analytics and Predictive Modeling—to generate the data required for continued research and potential for longer-term support. The Center has worked with 38 users in the past, and the Pilot Research Project Core will ensure that this pipeline of innovative research and ideas continues to take advantage of the opportunities and expertise offered by our Center. Applicants who propose feasibility studies, who want to explore how to incorporate `omics data into their research, or what to start a new direction that fits the NIDA and Center research areas may qualify for support from the Pilot Core. To improve overall Center capabilities that will benefit multiple users, the Pilot Core will also support small technical, methodological, or conceptual developments from staff and users to improve Center measurement and informatics capabilities. Toward those goals, we outline three exemplary initial pilot projects targeting neuropeptides, transmitters, and proteins that are involved in multiple aspects of drug use. The first of the initial projects will address a longstanding question, the route of formation of endomorphin 2; the second project will seek to obtain an unprecedented level of chemical dimensionality and resolution in order to address individual neural plasticity and the influence of social environments while bringing an outstanding neuroscience team into the addiction research area; the third project will explore the mystery of co-transmission dynamics by hyphenating nanoelectrochemistry and mass spectrometry to explore how co-transmission affects neurotransmitter phenotype plasticity of neurons in relation to drug use. We will solicit new proposals each year, and support up to eight additional projects for competitive review by the Core over the next five years. The Core has a rigorous process in place to solicit, assess, and select Pilot Projects. Overall, the new Pilot Research Project Core is an important component of the UIUC Center for Neuroproteomics and Neurometabolomics on Cell-Cell Signaling.

试点研究项目的核心固体，评估并支持新的和创新的可行性研究 UIUC神经蛋白质组学和神经代谢组学中心在细胞 - 细胞信号传导上。我们的核心（和中心）是 当我们促进有前途的年轻调查员的成功时，取得了成功 能力或成瘾研究，我们还鼓励知名研究人员探索新的方向 在成瘾研究中。选定的飞行员项目将可以访问我们的考虑中心资源 通过我们的科学核心获得 - 采样和分离，分子分析和表征以及 生物信息学，数据分析和预测建模 - 生成持续研究所需的数据 并潜力长期支持。该中心过去曾与38位用户合作，并进行了试点研究 项目核心将确保这种创新研究和思想的管道继续利用 我们中心提供的机会和专业知识。提出可行性研究的申请人 探索如何将“ OMIC数据”纳入他们的研究，或者启动适合NIDA的新方向 中心研究领域可能有资格获得飞行员核心的支持。提高总体中心功能 这将使多个用户受益，飞行员核心还将支持小型技术，方法论或概念 员工和用户的发展以提高中心测量和信息能力。朝向那些 目标，我们概述了针对神经肽，发射机和蛋白质的三个典范初步试点项目，这些项目 参与吸毒的多个方面。初始项目的第一个将解决一个长期存在的问题， 内啡肽2的形成途径；第二个项目将寻求获得前所未有的水平 化学维度和解决方案，以解决单个中性可塑性和影响 社会环境，同时将杰出的神经科学团队带入成瘾研究领域； 第三个项目将通过连字符纳米电解化学和 质谱法探索共汇率如何影响神经元的神经递质表型可塑性 与吸毒有关。我们每年将征集新建议，并最多支持八个其他项目 核心在接下来的五年中进行竞争评论。核心有一个严格的征求过程， 评估并选择试点项目。总体而言，新的试点研究项目核心是 UIUC神经蛋白质组学和神经代谢组学中心在细胞细胞信号传导上。