T32 Predoctoral training grant in Glycosciences

T32 糖科学博士前培训补助金

• 批准号: 10650310
• 负责人: I JONATHAN AMSTER
• 金额: $ 21.22万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10650310
• 关键词: Grant; Training; pre-doctoral

This application requests T32 funding to support pre-doctoral training at the chemistry-biology interface at the University of Georgia. This award will replace the current T32 Glycoscience Training Program (GTP) that was established in 2014. The mission of the GTP is to train the next generation of glycoscience researchers and prepare them for impactful careers in the biomedical workforce. In 2012 the National Academy of Sciences and Engineering issued a report concluding that the Glycosciences were significantly understudied in the United States and encouraged government agencies including the NIH to develop training programs to accelerate discovery in this critical research area. Despite the significant role that glycans play in biology and medicine, no other T32 training program in the United States focuses on glycans; thus, the GTP broadens the scope of NIH- supported training programs. The GTP capitalizes on the uniquely rich environment for carbohydrate research that exists at the University of Georgia. Twenty-four researchers from eight departments will serve as trainers for a diverse group of pre-doctoral students. Trainees are selected from a pool of applicants that enter the university’s graduate program either through the Integrated Life Sciences (ILS) umbrella program or through admission into the Department of Chemistry. The grant will provide stipends for six trainees per year for two- year appointments. The university will provide funding for two additional trainees per year to expand the impact of the GTP. The principal objective of this program is to provide a broad background in glycoscience with the ability to carry that knowledge forward into a variety of careers. Training emphasizes scientific reasoning, rigor in research design, quantitative skills, and data analysis. All trainees will enroll in professional development courses on the Responsible Conduct of Research and on Rigor, Reproducibility, and Transparency, and take foundational courses in Glycochemistry and Glycobiology. All of these courses are open to any student, broadening the impact of the GTP beyond the T32-supported trainees. Trainees can select from a variety of courses to build knowledge and skills in analytical, computational, or biological methods. Opportunities will be provided to develop strong written and oral communication skills in coursework, journal clubs, and seminar programs. The trainers will provide a supportive, inclusive, and diverse training environment, and are committed to continuous improvement as mentors through participation in workshops and training programs on topics such as effective mentoring, safe space in the workplace, and implicit bias. Mentor effectiveness will be evaluated using metrics developed with a recent supplemental grant to T32 and T25 programs on the UGA campus, and these data will guide the continuous improvement of mentoring in the GTP. We will track student outcomes and use annual program evaluations to make evidence-based decisions to refine recruiting and training practices. Improved methods for mentoring and training will be disseminated widely to impact graduate training on a national scale.

该申请要求 T32 资金支持化学-生物学接口的博士前培训 佐治亚大学该奖项将取代目前的 T32 糖科学培训计划 (GTP) GTP成立于2014年。GTP的使命是培养下一代糖科学研究人员和 2012 年美国国家科学院和 工程部发布了一份报告，得出结论认为，美国对糖科学的研究严重不足 各州并鼓励包括 NIH 在内的政府机构制定培训计划，以加速 尽管聚糖在生物学和医学中发挥着重要作用，但没有发现这一关键研究领域。 美国的其他 T32 培训计划侧重于聚糖；因此，GTP 扩大了 NIH- 的范围 GTP 利用独特的丰富碳水化合物研究环境。 佐治亚大学八个系的 24 名研究人员将担任培训师。 为不同的博士前学生群体从进入该项目的申请者中选出。 大学的研究生课程可以通过综合生命科学（ILS）伞式课程或通过 这笔赠款将为六名学员每年提供两年的津贴。 大学将每年为两名额外的实习生提供资金，以扩大影响力。 该计划的主要目标是提供糖科学的广泛背景。 将这些知识运用到各种职业的能力 培训强调科学推理和严谨性。 研究设计、定量技能和数据分析方面的所有学员都将参加专业发展。 有关负责任的研究行为以及严谨性、可重复性和透明度的课程，并参加 糖化学和糖生物学基础课程所有这些课程都向任何学生开放。 将 GTP 的影响扩大到 T32 支持的学员之外。 学员可以从各种学员中进行选择。 培养分析、计算或生物学方法知识和技能的课程。 旨在培养课程作业、期刊俱乐部和研讨会中强大的书面和口头沟通技巧 培训师将提供支持性、包容性和多样化的培训环境，并且 致力于通过参加研讨会和培训项目作为导师不断改进 主题包括有效的指导、工作场所的安全空间和隐性偏见。 使用 UGA 最近对 T32 和 T25 项目的补充拨款开发的指标进行评估 校园，这些数据将指导 GTP 中指导的不断改进，我们将跟踪学生。 结果并使用年度计划评估来做出基于证据的决策，以完善招聘和 改进的指导和培训方法将得到广泛传播，以影响毕业生。 全国范围内的培训。

项目成果

High throughput screening of mesenchymal stromal cell morphological response to inflammatory signals for bioreactor-based manufacturing of extracellular vesicles that modulate microglia.

高通量筛选间充质基质细胞对炎症信号的形态反应，用于基于生物反应器制造调节小胶质细胞的细胞外囊泡。

• DOI: 10.1101/2023.11.19.567730
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Larey,AndrewM;Spoerer,ThomasM;Daga,KanupriyaR;Morfin,MariaG;Hynds,HannahM;Carpenter,Jana;Hines,KellyM;Marklein,RossA
• 通讯作者: Marklein,RossA