Pilot Testing of a Game-Based Intervention to Promote HPV Vaccination in Families with Unvaccinated Children

基于游戏的干预措施的试点测试，以促进有未接种疫苗的儿童的家庭接种 HPV 疫苗

• 批准号: 10647454
• 负责人: Angela Chia-Chen Chen
• 金额: $ 23.01万
• 依托单位: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-16 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10647454
• 关键词: Address; Administrator; Advocate; Age; Agreement; American; Arizona; Behavior; Behavioral; COVID-19; COVID-19 pandemic; COVID-19 prevention; Child; Child health care; Clinic; Clinic Visits; Clinical; Collaborations; Communication; Computers; Data; Decision Making; Devices; Disease; Disparity; Dose; Drops; Economic Burden; Economics; Education; Effectiveness; Effectiveness of Interventions; Eligibility Determination; Enrollment; Family; Feedback; Female; Goals; Health; Health Personnel; Healthcare; Healthcare Systems; Human Papilloma Virus Vaccination; Human Papilloma Virus Vaccine; Human Papilloma Virus-Related Malignant Neoplasm; Human Papillomavirus; Incidence; Institution; Intervention; Interview; Job loss; Knowledge; Knowledge acquisition; Learning; Literature; Malignant Neoplasms; Measures; Mediator; Methods; Mission; Modification; Morbidity - disease rate; Outcome; Parents; Participant; Patient Self-Report; Play; Preparation; Prevention; Process; Provider; Public Health; Randomized; Reduce health disparities; Reporting; Research; Risk; Risk Factors; Science; Self Efficacy; Structure; Tablets; Technology; Testing; Time; Treatment Efficacy; United States National Institutes of Health; Vaccinated; Vaccination; Vaccines; Video Games; Visit; Youth; acceptability and feasibility; aged; behavioral outcome; boys; care providers; cost; design; effective intervention; efficacy evaluation; expectation; girls; group intervention; health goals; health knowledge; implementation intervention; infection rate; innovation; innovative technologies; insight; longitudinal design; male; mortality; novel; pandemic disease; pilot test; post intervention; preventive intervention; recruit; response; sex; social; social cognitive theory; theories; therapy design; treatment as usual; unvaccinated; uptake; vaccine acceptance; videogame intervention

ABSTRACT An estimated 80 million Americans are currently infected with human papilloma virus (HPV). HPV is strongly associated with cancers for females and males. High morbidity, mortality, and economic burden are attributable to HPV-associated cancers. Given the high infection rate of HPV in the US, vigorous prevention efforts are needed—including timely and effective HPV vaccination for boys and girls. Before COVID-19, the youth vaccination rate was suboptimal with about 50% youth 13-17 years having been vaccinated in contrast to the national goal of 80%. Vaccination rates dropped dramatically during the pandemic. Evidence for game- based health interventions is promising to facilitate knowledge acquisition and retention, and to promote vaccination behaviors in youth. As healthcare providers often find it challenging to promote HPV education and vaccination in clinical settings, an educational gamed-based intervention to promote HPV vaccination among youth in clinical settings offers an innovative and scalable approach to address this disparity in children’s healthcare. Guided by Social Cognitive Theory, we propose to (1) examine the feasibility and acceptability of a new HPV preventive intervention, the HPV Detective video game, designed for youth and their parents; (2) explore pre-post, intervention-related change in vaccine intent and uptake as well as change in theoretically posited intervention mediators; and (3) assess the potential for broader intervention implementation. Using a sequential mixed-methods, 2-group (intervention vs usual care), longitudinal design, 64 parent-youth dyads (32/per study condition) will be recruited. Parent-youth dyads in the intervention will play HPV Detective (tablet format) at the clinic prior to the healthcare provider visits. The control dyads will receive standard clinic treatment. Youth ages 11-14 need to receive two doses, 6-12 months apart, for maximum protection; thus, three weekly reminder messages will be sent 6-mos post enrollment to participants in both conditions. Data will be collected at T0 (baseline), T1 (immediately post game for intervention only) and at T2 (7-mos post enrollment). At 7-mo post enrollment, semi-structured interviews will be conducted with a subset of 8 parent- youth dyads in the intervention group, representing differences in child sex, age, and game completion, to solicit parent/youth feedback about factors that influenced their engagement in the intervention during the clinical visit; interviews with 3 healthcare providers (1 administer, 2 providers) will be conducted to examine factors related to intervention implementation. This study addresses the significant public health problem of HPV-associated cancers through timely youth vaccination, aligning with the mission of NIH. If the findings are promising, we will conduct a larger-scale RCT to examine the efficacy and effectiveness of the intervention that is likely to impact cancer-related morbidity and mortality, and reduce economic and social costs related to HPV-associated diseases. The findings will also extend prevention science with respect to the use of innovative computer technology to reduce incidence of HPV-associated cancers.

抽象的 目前，估计有8000万美国人感染了人乳头状病毒（HPV）。 HPV强烈 与女性和男性的癌症有关。高发病，死亡率和经济伯恩（Burnen） 归因于HPV相关的癌症。鉴于美国HPV的高感染率，预防有力 需要努力 - 包括及时有效的HPV疫苗接种男孩和女孩。在Covid-19之前， 青年吸尘率是次优的，约有50％的青年13-17岁，与疫苗接种相反 国家目标80％。大流行期间疫苗接种率急剧下降。游戏证据 - 承诺基于健康干预措施，以促进知识获取和保留，并促进 青年的疫苗接种行为。由于医疗保健提供者经常发现促进HPV教育和 临床环境中的疫苗接种，这是一种基于教育的干预措施，以促进HPV疫苗接种 临床环境中的青年提供了一种创新且可扩展的方法，以解决儿童的这种差异 卫生保健。在社会认知理论的指导下，我们建议（1）检查一个 新的HPV预防性干预，HPV侦探视频游戏，专为青年及其父母设计； （2） 探索疫苗意图和摄取的与干预相关的前孔，理论变化 补贴干预媒介； （3）评估更广泛的干预实施的潜力。使用 顺序的混合方法，2组（干预与通常的护理），纵向设计，64个父母二元组 （每研究条件为32/32）将被招募。干预措施中的父母 - 青年二元组将玩HPV侦探（平板电脑 格式）在医疗保健提供者就诊之前的诊所。控制二元组将接受标准诊所 治疗。 11-14岁的青年需要接受两剂，分别为6-12个月，以获得最大的保护；因此， 在这两种情况下，将向参与者发送三个每周的提醒消息。数据将 在T0（基线），T1（仅用于干预后立即进行）和T2（7-MOS POST）收集 注册）。在7-MO职位入学时，将进行半结构化访谈，其中8个父母的子集 干预小组中的青年二元组，代表儿童性别，年龄和游戏结束的差异， 征求父母/青年的反馈，内容涉及影响他们在干预期间参与干预的因素 临床访问；将对3个医疗保健提供者（1名管理员，2个提供者）进行访谈以检查 与干预实施有关的因素。这项研究解决了重大公共卫生问题 通过及时的青年疫苗接种与HPV相关的癌症，与NIH的任务保持一致。如果发现是 有希望的是，我们将进行大规模的RCT，以研究干预措施的有效性和有效性 可能会影响与癌症相关的发病率和死亡率，并降低与 HPV相关疾病。这些发现还将扩展有关使用的预防科学 创新的计算机技术，以减少与HPV相关癌症的发生率。