Probing form and function of memory representations in the hippocampus of memory expert birds

探索记忆专家鸟类海马体记忆表征的形式和功能

基本信息

批准号：
10641392
负责人：
Emily Lambert Mackevicius
金额：
$ 15.7万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10641392
关键词：
3-Dimensional Address Affect Alzheimer&apos s Disease Animals Area Award Behavior Behavioral Biological Biological Models Birds Brain Calcium Cells Cognition Disorders Cognitive Collaborations Computers and Advanced Instrumentation Custom Data Decision Making Disease Progression Ecology Environment Equipment Event Exhibits Faculty Family Food Goals Head Hippocampus Human Imaging Techniques Impairment Individual Knowledge Lead Learning Link Location Mammals Maps Memory Mental disorders Mentors Methods Microscope Modeling Neurons Neurosciences Pattern Persons Population Positioning Attribute Postdoctoral Fellow Property Publishing Recurrence Rewards Rodent Side Site Source Space Models Sparrows System Techniques Technology Testing Training Universities Visit Work behavioral study cognitive task computer framework design experience experimental study laboratory experiment member memory recall model organism network architecture neural neuromechanism neuroregulation predictive modeling simulation skills spatial memory spatiotemporal success tenure track

项目摘要

Project Summary/Abstract Mental disorders that affect the hippocampus disrupt people’s ability to form one-shot memories. My goal is to lead an independent lab, linking biological properties of hippocampal neurons to the ability to perform memory- guided cognitive behaviors. To map cognitive behaviors to their underlying neural mechanisms, my lab will perform theoretical analyses and simulation of state-space models of cognitive behaviors, implementing these models in a recurrent network architecture with learning rules that match biological plasticity rules (Aims 3a, c). To precisely characterize memory-guided behaviors at real-world complexity, my lab will apply state-of-the-art behavioral tracking techniques in natural settings to foraging behavior of wintering birds, chickadees and sparrows (Aim 3b). As a theorist, I will actively collaborate with experimentalists, drawing on my experience recording from the brain in animals performing cognitive tasks. My postdoctoral work in the Aronov lab, at Columbia University’s Zuckerman Institute, focuses on neural activity underlying a hippocampus-dependent one-shot memory behavior, food-caching, in the model system chickadees, caching birds with extreme memory abilities. I developed new methods for recording large populations of neurons in the chickadee hippocampus while they cache and retrieve food, and methods for precisely tracking their caching behavior (Aim 1a). Probing the hippocampus at moments of caching, I found a new mode of hippocampal activity patterns (Aim 1b), which is reactivated when birds return to retrieve food (Aim 1c). To compare this one-shot mode to representations of consistent environmental features, I am reproducing, in food-caching birds, findings from rodents showing changes to place cells at consistent reward zones, and comparing this to one-shot representations of food-caching (Aim 2a). I am developing a theoretical state-space model that explains both one-shot and consistent representations in the hippocampus (Aim 2b), incorporating hippocampus-inspired neural mechanisms (Aim 2c). Here, I outline a training plan to expand my skills and experience to lead an independent lab doing a combination of theoretical and real-world behavioral studies. I will deepen my training in theoretical methods working with my co-mentor Prof. Larry Abbott, and through affiliation with the Columbia Center for Theoretical Neuroscience. My training in tracking real-world behavior will be guided by my collaborator Prof. Vladimir Pravosudov, the leading pioneer in tracking real-world chickadee behaviors, with an extended visit to his Cognitive and Behavioral Ecology Lab and field sites. For additional training designing and fabricating custom equipment, I will work with Dr. Tanya Tabachnik, who heads the Advanced Instrumentation Core at ZI. This additional training, with instrumental support from the K99/R00 award, will prepare me well, and make me a highly competitive candidate for tenure-track faculty positions.

项目摘要/摘要影响海马的精神障碍破坏了人们形成单一记忆的能力。我的目标是为了领导一个独立的实验室，将海马神经元的生物学特性与执行记忆的能力联系在一起引导认知行为。为了将认知行为映射到其潜在的神经机制，我的实验室将对认知行为的状态空间模型进行理论分析和模拟，实施这些模型复发网络体系结构中的模型具有与生物可塑性规则相匹配的学习规则（目标3A，C）。为了精确地表征现实世界中的记忆引导的行为，我的实验室将应用最新的实验室自然环境中的行为跟踪技术，以觅食越冬鸟，山雀和麻雀（AIM 3B）。作为理论家，我将积极与实验者合作，借鉴我的经验从大脑中记录动物执行认知任务的记录。我在哥伦比亚大学扎克尔曼学院的阿罗诺夫实验室的博士后工作，重点是神经在模型系统中，依赖海马依赖性的单发记忆行为的活动的活动山雀，以极端的记忆能力缓存。我开发了录制大型的新方法山雀海马中的神经元的种群在缓存和检索食物时，以及方法精确跟踪其缓存行为（AIM 1A）。在缓存时刻探测海马，我发现了一个海马活动模式的新模式（AIM 1B），当鸟类返回以检索食物时，它将重新激活（AIM 1C）。为了将这种单发模式与一致的环境特征的表示形式进行比较，我正在繁殖，在食物旁的鸟类中，啮齿动物的发现显示了将细胞放置在一致的奖励区域的变化，并且将其与食品探测的单次表示（AIM 2A）进行比较。我正在发展一个理论状态空间在海马（AIM 2B）中解释了一声和一致表示的模型，海马启发的神经机制（AIM 2C）。在这里，我概述了一个培训计划，以扩大我的技能和经验，以领导独立实验室做一个理论和现实世界行为研究的结合。我将加深理论方法的培训与我的同事拉里·雅培（Larry Abbott）合作，并与哥伦比亚理论中心合作神经科学。我在跟踪现实世界行为方面的培训将由我的合作者弗拉基米尔教授指导 Pravosudov是追踪现实世界山雀行为的主要先驱认知和行为生态学实验室和现场站点。用于其他培训设计和制造自定义设备，我将与ZI高级仪器核心负责人Tanya Tabachnik博士合作。这在K99/R00奖的器乐支持下，其他培训将为我做好准备，并使我成为一个统治教师职位的竞争激烈的候选人。