Advancing the science of neurocognitive physiology in adolescents living with HIV

推进青少年艾滋病毒感染者的神经认知生理学科学

基本信息

批准号：
10453598
负责人：
Megan Song McHenry
金额：
$ 15.75万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10453598
关键词：
17 year old Adolescent Adverse effects Africa Africa South of the Sahara African Auditory Biological Assay Brain Child Childhood Clinical Research Cognition Cognitive Cognitive deficits Collaborations Communities Complex Consult Data Degree program Educational workshop Evaluation Event Event-Related Potentials Fostering Functional Magnetic Resonance Imaging Funding Geographic Locations Goals HIV HIV Infections Health Human Impaired cognition Impairment Individual Infrastructure Intervention Kenya Knowledge Lead Life Liquid substance Malnutrition Master&apos s Degree Measures Mediating Medical Medical History Medical Psychology Mentors Mentorship Methodology Methods Mission Modeling Motor Neurobiology Neurocognition Neurocognitive Neurocognitive Deficit Neuropsychology Neurosciences Neurotransmitters Outcome Perinatal Physiology Population Posture Predictive Factor Process Publishing Reporting Research Research Support Resources Risk Factors Science Sensory Series Signal Transduction Site Students Supervision Synapses System Teacher Professional Development Techniques Testing Time Training Training Programs United States National Institutes of Health Universities Viral Load result Visual Work Youth adverse outcome antiretroviral therapy cognitive function cohort cost effective disability experience eyeblink conditioning faculty support improved outcome indexing information processing motor learning nervous system disorder neurodevelopment neurophysiology peer perinatal HIV portability programs response sociodemographic factors sociodemographics symposium therapeutic target therapy adherence virtual

项目摘要

PROJECT SUMMARY Adolescents living with HIV (ALHIV) have been shown to experience neurocognitive impairment compared to their uninfected peers, but the underlying neurophysiology considered to be the fundamental building blocks of complex cognitive processing have not been rigorously studied within this population. Therefore, there is a crit- ical need for a comprehensive study of neurophysiology and cognitive function in ALHIV, especially in sub-Sa- haran Africa, which comes with unique health and socio-demographic risk factors that compound the adverse effects of HIV infection. The specific objectives of the proposed project is to: (1) determine the impact of HIV infection on neurophysiology and neurocognition in perinatally-infected adolescents and identify potential me- diating factors; and (2) build capacity for interdisciplinary neurophysiological research in sub-Saharan Africa by supporting intensive training for faculty development and tiered mentoring in neurophysiological methodologi- cal techniques. The central hypothesis is that ALHIV will show altered neurophysiology and impaired cognition compared to their unexposed peers. The rationale for this study is that evaluations utilizing event-related poten- tials (ERP) are uniquely suited determine which sensory and information processing stages are impaired and contribute to cognitive abnormalities in ALHIV. In Aim 1, we will determine the impact of HIV infection on neurophysiology and neurocognition in perinatally-infected adolescents and identify potential mediating socio- demographic and health/medical factors. To achieve this aim we will characterize ERP responses and their rela- tionship to cognitive function in ALHIV (14-17 years old) compared to uninfected adolescents (n=50/group) to develop a model to determine childhood factors predictive of poor neurophysiological and cognitive outcomes. Cognitive and sensory ERP paradigms, associative motor learning and motor coordination tasks, and a culturally adapted version of the NIH Toolbox Fluid Cognition tests will be administered within Aim 1. In Aim 2, we will build capacity for interdisciplinary neurophysiological research by supporting intensive training for faculty de- velopment and tiered mentoring in neurophysiological methodological techniques. Within this aim, we will sup- port the faculty and students within the Moi University’s training programs in performing neuropsychological work, for both clinical and research purposes. This will be done through a series of training workshops, monthly virtual seminars, and on-site supervision, which will culminate within a national symposium to foster neuro- physiological research collaboration across Kenya. The proposed work is significant because it will be the first comprehensive neurophysiological study of ALHIV in sub-Saharan Africa, and Moi University will be the only Kenyan academic center with sustainable capacity for research in neurophysiology. Funding this proposal would strengthen and promote national collaboration aimed at identifying mediating health and sociodemographic fac- tors for intervention and facilitating the identification of therapeutic targets to improve the outcomes of individ- uals across the African continent.

项目摘要与艾滋病毒（ALHIV）的青少年相比，已经显示出具有神经认知障碍他们未感染的同龄人，但基本的神经生理学被认为是在该人群中，复杂的认知处理并未严格研究。因此，有一个批评对ALHIV中神经生理学和认知功能的全面研究的需求，特别是 Haran Africa，带有独特的健康和社会人口统计学风险因素，使对敌人更加复杂艾滋病毒感染的影响。拟议项目的具体目标是：（1）确定艾滋病毒的影响对周围感染的青少年的神经生理学和神经认知感染，并鉴定潜在的我划分因素；（2）在撒哈拉以南非洲的跨学科神经生理研究的能力在神经生理学方法论中，支持教师发展和分层心理培训 CAL技术。中心假设是ALHIV将显示出改变的神经生理学和认知受损与他们意外的同龄人相比。这项研究的理由是，利用事件相关的有效性的评估 TIALS（ERP）唯一适合确定哪些感官和信息处理阶段受到损害，并且有助于ALHIV的认知异常。在AIM 1中，我们将确定HIV感染对周围感染的青少年的神经生理学和神经认知，并确定潜在的介导社会 - 人口统计和健康/医疗因素。为了实现这一目标，我们将表征ERP的回应及其相关性与未感染的青少年（n = 50/组）相比开发一个模型来确定儿童时期因素可预测差神经生理和认知结果。认知和感觉ERP范式，关联运动学习和运动协调任务以及文化上 NIH工具箱流体认知测试的改编版将在AIM 1中进行管理。在AIM 2中，我们将通过支持教师的深入培训来为跨学科的神经生理研究增强能力神经生理方法学技术中的速度和分层指导。在这个目标中，我们将为在MOI大学的培训计划中向教职员工移植在神经心理学方面出于临床和研究目的的工作。这将通过一系列的培训研讨会，每月一次虚拟的半手和现场监督，这将在全国性的研讨会中达到顶峰，以促进神经肯尼亚的生理研究合作。拟议的工作很重要，因为它将是第一个撒哈拉以南非洲和MOI大学的ALHIV的全面神经生理研究将是唯一的肯尼亚学术中心具有可持续的神经生理研究能力。为此提议提供资金加强和促进国家合作，旨在确定中介健康和社会人口统计学方面用于干预和支持鉴定治疗靶标的TOR，以改善个体的结果非洲大陆的UALS。