CHIcago Center for Accelerating nextGen Omics, deep phenotyping, and data science in Heart Failure (CHICAGO-HF)

芝加哥加速心力衰竭下一代组学、深度表型分析和数据科学中心 (CHICAGO-HF)

• 批准号: 10327554
• 负责人: Sadiya Sana Khan
• 金额: $ 28.24万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10327554
• 关键词: Abdomen; Address; Adult; Affect; Age; Artificial Intelligence; Biology; Biopsy; Cardiac; Chicago; Clinical; Clinical Research; Collaborations; Communities; Complex; Data; Data Analytics; Data Science; Development; Disease; EFRAC; Echocardiography; Electronic Health Record; Elements; Environment; Epidemiology; Ethnic Origin; Exercise; Failure; Federally Qualified Health Center; Four-dimensional; Functional disorder; Funding; Genomics; Geography; Goals; Health Expenditures; Heart failure; Heterogeneity; Illinois; Imaging Techniques; Informatics; Infrastructure; Knowledge; Lead; Magnetic Resonance Imaging; Mission; Morbidity - disease rate; Multimodal Imaging; Myocardial; Myocardial perfusion; Myocardium; National Heart, Lung, and Blood Institute; National Human Genome Research Institute; Nature; Network-based; Observational Study; Outcome; Patient-Focused Outcomes; Patients; Phase; Phenotype; Population Heterogeneity; Positioning Attribute; Precision Medicine Initiative; Prevalence; Prospective cohort; Protocols documentation; Public Health; Public Health Informatics; Race; Randomized Controlled Trials; Resources; Retrospective cohort; Sampling; Science; Site; Skeletal Muscle; Socioeconomic Status; Sodium; Syndrome; Testing; TimeLine; Tissues; Trans-Omics for Precision Medicine; Translating; United States National Institutes of Health; Woman; Work; base; body system; clinical center; cohort; comorbidity; data warehouse; effective therapy; ethnic minority population; experience; improved; improved outcome; innovation; insight; mortality; multidisciplinary; new therapeutic target; next generation; patient population; phenomics; phenotypic data; precision medicine; preservation; prevent; programs; prospective; racial and ethnic; recruit; response; sex; success; support network; targeted treatment; therapeutic target; tool

ABSTRACT This application proposing the CHIcago Center for Accelerating nextGen Omics, deep phenotyping, and data science in Heart Failure (CHICAGO-HF) is in response to the RFA “HeartShare: Next-Generation Phenomics to Define Heart Failure Subtypes and Treatment Targets-Clinical Centers.” Heart failure with preserved ejection fraction (HFpEF) is associated with significant morbidity and mortality and is increasing in prevalence. No effective disease-modifying therapies exist for patients with HFpEF, largely due to the substantial heterogeneity among patients with HFpEF for whom the current “one-size-fits-all” treatment paradigm is failing. A large-scale, multicenter observational study to conduct deep phenotyping in patients with HFpEF is a critical next step to advance our understanding of HFpEF pathophysiology and shift our clinical and research paradigm in HFpEF towards a precision medicine approach. We propose three central elements that are critical to address to comprehensively phenotype patients across the spectrum of HFpEF. First, direct phenotyping of the myocardium, using tools such as magnetic resonance imaging (MRI) and endomyocardial biopsy, is necessary to elucidate the intrinsic myocardial biology of HFpEF. Second, detailed phenotyping of the complex interplay of extra-cardiac comorbidities is needed to better understand the systemic nature of HFpEF. Third, a representative sample of HFpEF patients with diversity across sex, race/ethnicity, geography, and socioeconomic status needs to be included in phenotyping efforts to prevent widening of well-documented disparities in HFpEF. The proposed Clinical Center, CHICAGO-HF, led by Northwestern, is uniquely qualified to participate in all aspects of the HeartShare Network and to substantially enhance the Network’s goals. In our application, we demonstrate key prior experiences, which include: (1) development of the world’s first dedicated clinical program in HFpEF; (2) recruitment of large numbers of patients with HFpEF into multicenter observational studies and trials; and (3) participation as a Field Center for NHLBI-funded cohorts. Our well- resourced multi-disciplinary investigative team has expertise in epidemiology, informatics, deep phenotyping, and artificial intelligence. We will leverage our experiences with our robust electronic health record infrastructure to efficiently collect, harmonize and share retrospective and prospective data on a large number of diverse patients with HFpEF and age- and sex-matched controls (HF with reduced and mid-range EF and healthy controls). We will prospectively recruit at least 250 patients within the study timeline with community partners across Chicago (e.g. Federally Qualified Health Centers). In addition, our unique expertise in innovative MRI techniques and data analytics can strengthen the Network and will enable testing of significant and innovative hypotheses to define unique phenotypes, elucidate distinct endotypes that represent underlying pathobiology, and identify novel targeted therapeutics for HFpEF. CHICAGO-HF is ideally suited to serve as a Clinical Center and contribute to the Network’s long-term mission to equitably improve HFpEF outcomes.

抽象的 该申请提出了芝加哥加速NextGen Omics，深层表型和 心力衰竭中的数据科学（芝加哥-HF）是对RFA“心脏夏天：下一代的回应 定义心力衰竭亚型和治疗目标的现象学中心。 保留的射血分数（HFPEF）与显着的发病率和死亡率有关，并且正在增加 流行率。 HFPEF患者不存在有效调整疾病的疗法，主要是由于 HFPEF患者的实质异质性 范式失败了。一项大规模的多中心观察研究，以对患者进行深层表型 HFPEF是促进我们对HFPEF病理生理学的理解并改变我们的临床和 HFPEF的研究范式针对精确的医学方法。我们提出了三个中心元素 对于在HFPEF范围内全面的表型患者解决至关重要。首先，直接 心肌的表型，使用磁共振成像（MRI）和心内膜的工具 活检对于阐明HFPEF的内在心肌生物学是必不可少的。其次，详细的表型 需要外出合并症的复杂相互作用，以更好地了解 HFPEF。第三，在性别，种族/种族，地理，地理，种族/种族，种族/种族多样性的HFPEF患者中的代表性样本 和社会经济地位需要包括在表型努力中，以防止有据可查 HFPEF的差异。拟议的临床中心芝加哥-HF由西北地区领导，具有独特的资格 参与心脏网络的各个方面，并大大提高网络的目标。在我们的 应用程序，我们展示了关键的先前经验，其中包括：（1）开发世界第一个 HFPEF专用临床计划； （2）将大量HFPEF患者招募到多中心 观察研究和试验； （3）参与NHLBI资助的队列的现场中心。我们的福祉 资源的多学科调查团队在流行病学，信息信息，深层表型中具有专业知识， 和人工智能。我们将通过强大的电子健康记录来利用我们的经验 基础架构可有效收集，协调和共享大量的回顾性和前瞻性数据 患有HFPEF以及年龄和性别匹配对照的潜水员患者（HF降低和中端EF以及 健康控制）。我们可能会在研究时间表中与社区招募至少250名患者 芝加哥各地的合作伙伴（例如联邦合格的卫生中心）。此外，我们的独特专业知识 创新的MRI技术和数据分析可以增强网络，并能够测试大量 和创新的假设以定义独特的表型，阐明代表基础的不同内型 病理生物学，并确定针对HFPEF的新型靶向疗法。芝加哥-HF非常适合用作 临床中心并为该网络的长期任务做出了贡献，以同样改善HF​​PEF结果。