Biodefense Training Program

生物防御培训计划

• 批准号: 10444921
• 负责人: ASHOK K CHOPRA
• 金额: $ 17.88万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10444921
• 关键词: Training Programs; biodefense

This is a third competitive renewal of our very successful Biodefense Training Program (BTP) for predoctoral students; first funded in 2004, prior to the building of the Galveston National Laboratory (GNL) in 2008. Since then, there has been an explosive growth of research at UTMB on biodefense-related and other emerging/re- emerging microbes of significant public health concern. The goal of this grant remains to train a new generation of scientists for diverse careers in a variety of research disciplines critical to protecting the U.S. and the rest of the world from bioweapons and epidemics/pandemics caused by naturally emerging, highly pathogenic bacteria and viruses. With significant advances in biotechnology, concerns have intensified regarding the development of artificially engineered microbes that have the potential to spread more quickly, are more lethal, and resist prevention or treatment options. Therefore, continued development of novel countermeasures is needed, and concerted efforts by the federal government to train next generation scientists capable of safely working at BSL- 3 and BSL-4 containment at both academic campuses and government facilities remain critical. UTMB is particularly well qualified to train these scientists by virtue of the existence of the GNL, which has comprehensive maximum containment and excellent core facilities, successful and well-funded major biodefense research programs, and a highly developed biocontainment training program. Furthermore, UTMB faculty have developed countermeasures already in use in patients (e.g., Ebola vaccine) or are in late preclinical and early clinical trial stages. The strong and diverse biodefense and emerging infectious disease research portfolio ranges from vaccine development to diagnostics, antimicrobial development to pathogenesis, and these programs are highly collaborative, interdisciplinary, and translational in nature. The BTP supports four PhD or MD/PhD students each year enrolled in one of four graduate programs: MICR, PATH, BMB, and HPTM. Trainees are selected for up to 2 years by an Executive Committee after they have completed their qualifying exam and have submitted a formal F31-style proposal describing their dissertation research. In addition to courses required by the respective programs, BTP trainees enroll in elective classes specific to biodefense and custom-designed to meet their needs, with a special focus on responsible conduct of research. With a structured mentoring plan, well-funded faculty participate in the program but an opportunity is provided to develop junior mentors through involvement of senior faculty as co-mentors in student supervision. Enrichment activities include retreats organized by the trainees to discuss career opportunities with invited past BTP trainees from academia, government, and industry, as well as to discuss topics in ethics and specific research themes. Trainees also organize an Immunology/Biodefense journal club, and there is close interaction of the students with seminar speakers during the weekly Infectious Diseases and Immunity Colloquium. A strong, multi-component program for recruiting URM trainees will be further augmented to develop a biodefense workforce mirroring the national population.

这是我们非常成功的生物充沛培训计划（BTP）的第三个竞争性更新 学生;自2008年加尔维斯顿国家实验室（GNL）建造之前，最早于2004年资助。 然后，在UTMB上，研究对生物陷入困境和其他新兴/重新爆发了爆炸性的增长 有重大公共卫生关注的新兴微生物。这笔赠款的目标仍然是培训新一代 科学家在各种研究学科中的多元化职业，对保护美国和其他地区至关重要 来自生物武器和流行病/流行病的世界是由自然出现的，高度致病的细菌引起的 和病毒。随着生物技术方面的重大进展，人们对发展的关注加剧了 人工工程的微生物有可能更快地传播，更致命，并且抵抗 预防或治疗选择。因此，需要持续发展新颖的对策，并且 联邦政府共同努力培训能够在BSL-安全工作的下一代科学家 在学术校园和政府设施中，3和BSL-4遏制仍然至关重要。 UTMB是 特别有资格通过GNL的存在来培训这些科学家 最大遏制和出色的核心设施，成功且资金良好的主要生物化研究 计划，以及高度发展的生物内在培训计划。此外，UTMB教师已经发展 已经在患者（例如埃博拉疫苗）或晚期临床前和早期临床试验中使用的对策 阶段。强大而多样化的生物化和新兴的传染病研究组合范围从 疫苗开发诊断，发病机理的抗菌剂发育，这些程序高度高 自然界的合作，跨学科和翻译。 BTP支持四个博士学位或MD/PHD学生 参加了四个研究生课程之一：MIC，PATH，BMB和HPTM。选拔的学员最多 执行委员会完成合格考试并提交正式考试后，执行委员会2年 F31风格的建议描述了他们的论文研究。除了各自需要的课程 计划，BTP受训者参加了专门针对生物幻想和定制设计的选修课，以满足其 需求，特别关注负责任的研究。有一个结构化的指导计划，资金充足 教师参加了该计划，但提供了一个机会，可以通过参与来培养初级导师 高级教职员工担任学生监督的联席会员。富集活动包括由 学员与学术界，政府和行业的过去的BTP学员讨论职业机会， 以及讨论道德和特定研究主题的主题。学员还组织了 免疫学/Biodefense期刊俱乐部，学生与研讨会扬声器有密切的互动 每周的传染病和免疫性座谈会。一个强大的多组分计划，用于招募URM 将进一步增加学员，以发展一支反映国家人口的生物防腐劳动力。