Integrated Next-generation RF Transmit, Receive and B0 shimming coil system for brain and spinal cord MRI at 7 Tesla

用于 7 特斯拉脑部和脊髓 MRI 的集成下一代射频发射、接收和 B0 匀场线圈系统

• 批准号: 10445118
• 负责人: Xinqiang Yan
• 金额: $ 43.93万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10445118
• 关键词: Address; Algorithms; Anatomy; Area; Behavior; Brain; Brain imaging; Cerebellum; Cerebrum; Cervical spinal cord structure; Cervical spine; Choking; Communities; Complex; Consumption; Data Analyses; Development; Disease; Electromagnetics; Elements; Engineering; Functional Imaging; Functional Magnetic Resonance Imaging; Geometry; Goals; Human; Image; Imaging technology; Impairment; Injury; Investigation; Light; Magnetic Resonance Imaging; Measures; Mechanics; Motor; Nature; Neuraxis; Noise; Organ; Pain; Pathway interactions; Pattern; Performance; Physiologic pulse; Process; Protocols documentation; Reproducibility of Results; Resolution; Rest; Route; Sensory; Signal Transduction; Site; Spinal Cord; Spinal cord injury; Structure; System; Therapy Evaluation; Vendor; Vertebral column; Weight; Work; base; chronic pain; density; design; design and construction; experimental study; human subject; improved; innovation; insight; interest; models and simulation; motor disorder; nervous system disorder; next generation; novel; operation; relating to nervous system; response; spinal cord imaging; tool; transmission process; virtual; Address; Algorithms; Anatomy; Area; Behavior; Brain; Brain imaging; Cerebellum; Cerebrum; Cervical spinal cord structure; Cervical spine; Choking; Communities; Complex; Consumption; Data Analyses; Development; Disease; Electromagnetics; Elements; Engineering; Functional Imaging; Functional Magnetic Resonance Imaging; Geometry; Goals; Human; Image; Imaging technology; Impairment; Injury; Investigation; Light; Magnetic Resonance Imaging; Measures; Mechanics; Motor; Nature; Neuraxis; Noise; Organ; Pain; Pathway interactions; Pattern; Performance; Physiologic pulse; Process; Protocols documentation; Reproducibility of Results; Resolution; Rest; Route; Sensory; Signal Transduction; Site; Spinal Cord; Spinal cord injury; Structure; System; Therapy Evaluation; Vendor; Vertebral column; Weight; Work; base; chronic pain; density; design; design and construction; experimental study; human subject; improved; innovation; insight; interest; models and simulation; motor disorder; nervous system disorder; next generation; novel; operation; relating to nervous system; response; spinal cord imaging; tool; transmission process; virtual

Project Summary/Abstract This proposal is to develop a pre-shimmed parallel transmit array, an optimized receive array, and an RF/ΔB0 array to correct the severe B1 inhomogeneity, maximize the signal-to-noise ratio (SNR), and correct B0 inhomogeneity in simultaneous human brain and spinal cord MR imaging 7 Tesla (T). Simultaneous functional imaging of the brain and spinal cord can provide valuable insight into interactions and processing pathways between these organs in normal and abnormal states of spinal cord injury, chronic pain, and motor disease. It is emerging as a new tool to study the central nervous system and is necessary to enable new investigations of task-based and resting-state sensory/motor processing throughout the cerebrum and spinal cord and shed new light on the nature of resting-state networks within the cerebellum and spinal cord. 7T MRI offers new opportunities to visualize structures of interest with high spatial resolution and enhanced conspicuity and to detect brain function and networks with greater sensitivity. However, at high fields, B1 and B0 inhomogeneities, and the lack of optimized receive coils for some specific applications are major challenges that limit imaging performance. Existed designs are aimed at either brain-only or spinal-cord-only applications, and none have solved all the challenges mentioned above. Moreover, the performance of these designs is limited by the small number of transmit channels available from scanner vendors, and a lack of optimization for actual imaging applications. The first goal of this project is to build a pre-shimmed transmit array which compresses 48 basic coils into 8-“virtual” coils with RF pulse jointly optimized weights, to maximize the transmit performance of standard 8-transmit-channel 7 Tesla scanners. The second goal of this project is to build a close-fitting massive- element receive array with optimum coil geometry/layout/size, to provide high SNR and excellent parallel imaging performance in both the whole brain and the spinal cord. The third goal of this project is to build routing-optimized low-profile RF/ΔB0 array to correct B0 inhomogeneity with less hardware complications. The optimization algorithms, electromagnetic simulation models, and electric/mechanical designs of the final pre-shimmed transmit array, high dense receive array and the routing-optimized ΔB0 arrays, will be distributed for open access. These transmit, receive, and ΔB0 arrays do not depend on the vendors’ platform and can be easily transferred to other 7T sites, with benefits for the entire community.

项目摘要/摘要 该建议是开发一个预险的平行传输阵列，优化的接收阵列和RF/ΔB0 数组以纠正严重的B1不均匀性，最大信号噪声比（SNR）和校正B0 同时人脑和脊髓MR成像7特斯拉（T）的不均匀性。同时功能 大脑和脊髓的成像可以为相互作用和处理途径提供宝贵的见解 在正常和异常的脊髓损伤，慢性疼痛和运动疾病状态下这些器官之间。这是 作为研究中枢神经系统的新工具，有必要实现新的投资 整个大脑和脊髓基于任务和静止状态的感觉/运动处理 小脑和脊髓内静止状态网络的性质。 7T MRI提供新的 通过高空间分辨率和增强的显着性以及 检测具有更高灵敏度的大脑功能和网络。但是，在高领域，B1和B0不均匀性， 缺乏优化的接收线圈，用于某些特定应用是限制成像的主要挑战 表现。存在的设计针对仅脑部或仅脊柱的应用，并且没有 解决了上面提到的所有挑战。而且，这些设计的性能受到小的限制 扫描仪供应商可获得的传输通道数量，并且缺乏对实际成像的优化 申请。该项目的第一个目标是构建一个预先缩小的传输阵列，该阵列压缩48个基本 线圈成8-带有RF脉冲共同优化权重的8-“虚拟”线圈，以最大程度地发射性能 标准的8条通道7特斯拉扫描仪。该项目的第二个目标是建立一个近距离的大规模 - 元素接收具有最佳线圈几何/布局/尺寸的阵列，以提供高SNR和出色的并行成像 整个大脑和脊髓的表现。该项目的第三个目标是建立路由优化的 低调的RF/ΔB0阵列以更少的硬件并发症校正B0不均匀性。优化 最终预档的算法，电子仿真模型和电气/机械设计 发送阵列，高密度接收阵列和路由优化的ΔB0阵列将分布以进行开放访问。 这些传输，接收和ΔB0阵列不取决于供应商的平台，并且很容易转移 到其他7T站点，对整个社区都有好处。