Stellenbosch University Clinical Trials Unit (SUN-CTU)

斯泰伦博斯大学临床试验中心 (SUN-CTU)

基本信息

批准号：
8784177
负责人：
Mark Fredric Cotton
金额：
$ 115.55万
依托单位：
STELLENBOSCH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-04-15 至 2020-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8784177
关键词：
AIDS clinical trial group AIDS/HIV problem Address Adherence Adolescent Adult Affect Age Antitubercular Agents Applied Research Biological Markers Caring Case Study Child Childhood Cities Clinical Clinical Research Clinical Treatment Clinical Trials Clinical Trials Unit Communicable Diseases Communities Comorbidity Development Diagnosis Diagnostic Diagnostic Procedure Disease Drug Kinetics Drug resistance in tuberculosis Epidemic Faculty Family Funding Agency Gender HIV HIV Infections HIV prevention trial Health Sciences Hepatitis B Hepatitis E High Prevalence Household IMPAACT Incidence Individual Infant Infection International Laboratories Link Low Birth Weight Infant Malignant neoplasm of cervix uteri Measures Medicine Multidrug-Resistant Tuberculosis National Institute of Allergy and Infectious Disease Participant Pharmaceutical Preparations Pharmacology Phase Phase III Clinical Trials Population Populations at Risk Positioning Attribute Pregnant Women Prevalence Prevention Prevention trial Protocols documentation Province Public Health Race Randomized Regimen Reporting Research Research Infrastructure Research Priority Research Project Grants Resistance South Africa Tuberculosis Tuberculosis Vaccines Twin Multiple Birth Universities Vaccines antiretroviral therapy bactericide base burden of illness clinical care clinical research site co-infection design improved innovation medical specialties mycobacterial neonate neurodevelopment novel premature prevent safety study treatment effect treatment trial trial design tuberculosis drugs tuberculosis treatment vaccination against tuberculosis vaccination strategy vaccine trial

项目摘要

DESCRIPTION (provided by the applicant): Our overall objective is to provide safe, effective, practical family-centered and integrated prevention, treatment and cure for HIV, TB and other comorbidities in individuals of all races, ages and gender, continuously refined through quality research, innovation and implementation. HIV/AIDS and TB are major global public health problems. South Africa has the highest population prevalence of HIV infection globally and the highest incidence in the world, with >60% of TB cases also HIV-infected. The SUN-CTU is located at the Faculty of Medicine and Health Sciences in urban Cape Town, Western Cape Province of South Africa, an epicenter of these twin epidemics, serving a population of approximately 2.5 million. SUN-CTU combines excellence in research and clinical care with a high prevalence of HIV and TB and populations accessed through 3 closely linked Clinical Research Sites (CRSs) with complementary research focus, strategically situated satellites and proven capacity for a broad spectrum of research. SUN-CTU has a strong family-centered approach, focusing on HIV- and TB-related research and care to large at-risk populations, spanning low birth weight and premature neonates, infants, children, adolescents and adults of all ages. The proposed well-integrated SUN-CTU is a pluripotent network expansion of an existing smaller CTU, at the Children's Infectious Diseases Clinical Research Unit (KID-CRU), focused on IMPAACT network activities. SUN-CTU has already demonstrated considerable capacity to conduct multiple clinical research projects through NIAID and other funding sources, and is particularly well aligned for participation in the IMPAACT, ACTG and HPTN networks. RELEVANCE: South Africa-has a high population prevalence of HIV and TB infection, with >60% of TB cases also HIV infected. The SUN-CTU comprises 3 pluripotent CRSs with complementary research focus and a strong family-centered approach, focusing on HIV- and TB-related research and care to large at-risk populations, spanning low birth weight and premature neonates, infants, children, adolescents and adults of all ages.

描述（由申请人提供）：我们的总体目标是为所有种族、年龄和性别的个人提供安全、有效、实用、以家庭为中心的综合预防、治疗和治愈艾滋病毒、结核病和其他合并症，并通过质量不断完善研究、创新和实施。艾滋病毒/艾滋病和结核病是全球主要的公共卫生问题。南非是全球艾滋病毒感染率最高的国家，也是全球发病率最高的国家，超过 60% 的结核病病例同时感染艾滋病毒。 SUN-CTU 位于南非西开普省开普敦市区的医学与健康科学学院，这里是这两种流行病的中心，为大约 250 万人口提供服务。 SUN-CTU 将卓越的研究和临床护理与艾滋病毒和结核病的高患病率以及通过 3 个紧密相连的临床研究中心 (CRS) 接触的人群结合起来，这些中心具有互补的研究重点、战略性定位的卫星以及经过验证的广泛研究能力。 SUN-CTU 采取强有力的以家庭为中心的方法，重点关注艾滋病毒和结核病相关的研究以及对大量高危人群的护理，涵盖低出生体重和早产儿、婴儿、儿童、青少年和所有年龄段的成人。拟议的集成良好的 SUN-CTU 是儿童传染病临床研究单位 (KID-CRU) 现有较小 CTU 的多能网络扩展，重点关注 IMPAACT 网络活动。 SUN-CTU 已经展示了通过 NIAID 和其他资金来源开展多个临床研究项目的相当大的能力，并且特别适合参与 IMPAACT、ACTG 和 HPTN 网络。相关性：南非的艾滋病毒和结核病感染率很高，超过 60% 的结核病病例也感染了艾滋病毒。 SUN-CTU 由 3 个多能 CRS 组成，具有互补的研究重点和强有力的以家庭为中心的方法，重点关注艾滋病毒和结核病相关的研究以及对大量高危人群的护理，涵盖低出生体重和早产儿、婴儿、儿童、所有年龄段的青少年和成人。