MSM and Substances Cohort at UCLA Linking Infections Noting Effects (MASCULINE)

加州大学洛杉矶分校的 MSM 和物质队列将感染注意影响联系起来（男性）

基本信息

批准号：
9062608
负责人：
Pamina Mae Gorbach
金额：
$ 1.26万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-30 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9062608
关键词：
AIDS prevention AIDS/HIV problem Acquired Immunodeficiency Syndrome Adherence Advisory Committees Affect Age Alcohol or Other Drugs use Amphetamines Anti-Retroviral Agents Anus Archives Basic Science Behavior Behavioral Biological Biological Testing Biopsy Blood CD4 Positive T Lymphocytes California Caring Chlamydia Cohort Studies Communicable Diseases Communities County Crack Cocaine Data Drug usage Drug user Epidemic Epidemiology Fostering Gonorrhea HIV HIV Infections HIV Seropositivity HIV risk HIV therapy HIV-1 HIV/STD Health Health Insurance Portability and Accountability Act Hepatitis C Hepatitis C virus Heroin High Prevalence Hispanics Immune Immunology Improve Access Incidence Individual Infection Inflammatory Inflammatory Response Injecting drug user Knowledge Lead Link Liquid substance Los Angeles Measurable Methamphetamine Minority Mucositis Mucous Membrane National Institute of Allergy and Infectious Disease National Institute of Drug Abuse Pathogenesis Pattern Pharmaceutical Preparations Plasma Population Predisposition Prevalence Prevention Public Health Recording of previous events Recruitment Activity Research Research Infrastructure Research Personnel Risk Risk Behaviors Sampling Science Sexual Transmission Sexually Transmitted Diseases Source Specimen Substance abuse problem Syphilis Tissues Treatment Protocols Universities Viral Load result Visit Work base biobank clinically relevant cohort comparative cytokine ecstasy high risk immune function innovation mathematical model medication compliance member men who have sex with men non-drug novel rectal repository response seropositive sexually active transmission process treatment adherence

项目摘要

DESCRIPTION (provided by applicant): This application in response to NIDA PAR 12-222 Cohort Studies of HIV/AIDS and Substance Use (U01) seeks to leverage extensive existing infrastructure and cohorts at the University of California, Los Angeles to launch a new cohort of substance using minority (Black or Hispanic) men who have sex with men (MMSM). The epidemic of HIV among MMSM in the US and locally in Los Angeles County (LAC) may be driven by effects of substance use on adherence to treatment regimens and bio-behavioral prevention and enhanced by high prevalence networks. Proposed investigators lead the science on studying associations between non-injection drug use, risk behaviors and infectious disease among MSM, and contribute a broad portfolio of inter-disciplinary work from immunology and basic science to epidemiology, prevention and treatment. The work proposed leverages existing cohorts including the Multicenter AIDS Cohort (MACS) and existing repositories and builds on preliminary work to guide assembly of a cohort for the study of basic and behavioral factors in younger MMSM who actively use substances and engage transmission risks. Establishing a cohort of young active substance users, particularly stimulant users, who have poor histories of antiretroviral treatment (ART) adherence as marked by measurable and clinically relevant Plasma Viral Load (PVL) will enable important tests of biological influences of substances on immune function in MMSM. This cohort is central to prevention and treatment efforts and will provide well-characterized, extensive repository samples for leveraged use with other cohorts, networks' and individual's studies. The MMSM will be: (i) HIV-positive with viral load >5000 copies/ml or (ii) HIV-negative at high risk for HIV infection (unprotected anal intercourse in the past 6 months). This unique cohort will facilitate studies on interactions between substance use and HIV progression and/or transmission, which are of critical public health significance. This cohort of MMSM will characterize: (i) effects substance use on behavioral and network level risk in exposed and infected MMSM on acquisition of HIV and other sexually transmitted infections (STIs: gonorrhea, Chlamydia, syphilis, Hepatitis C (HCV)); and (ii) the extent to which substance use in MMSM facilitates behaviors that transmit HIV compared to non-drug using MMSM. The application also proposes to develop and maintain a bio repository that is HIPAA-compliant, technologically-current and DAIDS Network interfaced that includes a scientific advisory committee. This cohort will comprise 620 MMSM with repeated data visits (from 1,080 MMSM). At least half of these MMSM will be active substance users and younger than age 30.

描述（由申请人提供）：本申请响应 NIDA PAR 12-222 HIV/AIDS 和药物使用队列研究 (U01)，旨在利用加州大学洛杉矶分校现有的广泛基础设施和队列来启动一个新队列使用与男性发生性关系的少数族裔（黑人或西班牙裔）男性 (MMSM) 的物质。美国和洛杉矶县 (LAC) 的 MMSM 中艾滋病毒的流行可能是由于药物使用对治疗方案依从性和生物行为预防的影响所驱动，并因高流行网络而加剧。拟议的研究人员领导了研究 MSM 中非注射毒品使用、危险行为和传染病之间关系的科学，并贡献了从免疫学和基础科学到流行病学、预防和治疗的广泛的跨学科工作。拟议的工作利用了包括多中心艾滋病队列 (MACS) 在内的现有队列和现有存储库，并以初步工作为基础，指导组建队列，以研究积极使用药物并承担传播风险的年轻 MMSM 的基本和行为因素。建立一组年轻的活性物质使用者，特别是兴奋剂使用者，他们抗逆转录病毒治疗（ART）依从性较差，以可测量和临床相关的血浆病毒载量（PVL）为标志，这将有助于对物质对免疫功能的生物学影响进行重要测试。 MMSM。该队列对于预防和治疗工作至关重要，并将提供特征明确、广泛的存储样本，以便与其他队列、网络和个人的研究一起使用。 MMSM 将是：(i) HIV 阳性，病毒载量 >5000 拷贝/ml 或 (ii) HIV 阴性，有 HIV 感染高风险（过去 6 个月内有无保护的肛交）。这个独特的队列将促进对物质使用与艾滋病毒进展和/或传播之间相互作用的研究，这对公共卫生具有重要意义。这组 MMSM 的特征是：(i) 暴露和感染 MMSM 的物质使用对艾滋病毒和其他性传播感染（性传播感染：淋病、衣原体、梅毒、丙型肝炎 (HCV)）的行为和网络水平风险的影响； (ii) 与不使用药物的 MMSM 相比，MMSM 中药物使用在多大程度上促进了 HIV 传播行为。该申请还建议开发和维护一个符合 HIPAA 要求、技术先进且与 DAIDS 网络接口的生物存储库，其中包括一个科学咨询委员会。该队列将包括 620 个具有重复数据访问的 MMSM（来自 1,080 个 MMSM）。这些 MMSM 中至少有一半是活性物质使用者且年龄小于 30 岁。