Disrupted Neural Connectivity in Empathy Deficits in Schizophrenia

精神分裂症共情缺陷的神经连接中断

• 批准号: 10295184
• 负责人: Amy M Jimenez
• 金额: --
• 依托单位: VA GREATER LOS ANGELES HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-10-01 至 2023-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10295184
• 关键词: Address; Affect; Affective; Anterior; Area; Belief; Brain; Brain region; Budgets; Categories; Cognitive; Complex; Computer Analysis; Data; Development; Diffusion Magnetic Resonance Imaging; Disease; Doctor of Philosophy; Dorsal; Educational Intervention; Emotional; Emotions; Empathy; Environment; Evaluation; Feeling; Functional Magnetic Resonance Imaging; Goals; Graph; Hand; Healthcare; Impaired cognition; Impairment; Inferior; Inferior frontal gyrus; Infrastructure; Insula of Reil; Intervention; Knowledge; Learning Skill; Literature; Lobule; Medial; Mentors; Methods; Motor; Movement; Multimodal Imaging; Neural Network Simulation; Neurosciences Research; Outcome; Pain; Parietal; Patient Care; Patients; Pattern; Persons; Prefrontal Cortex; Process; Psychologist; Psychopathology; Psychotic Disorders; Public Health; Publishing; Research; Research Design; Research Personnel; Schizophrenia; Seeds; Social Functioning; Social Interaction; Structure of superior temporal sulcus; System; Techniques; Training; Veterans; Visual; Work; base; career; cingulate cortex; cognitive training; cost; evidence base; experience; functional disability; graph theory; improved; indexing; innovation; interest; mental state; network architecture; neural network; neuroimaging; next generation; novel; poor communities; practical application; relating to nervous system; skills; social; tractography; translational neuroscience

Social interactions are dynamic exchanges that most people navigate with ease. However, these exchanges are actually quite complex and nuanced. Indeed, Veterans with schizophrenia often find them confusing, resulting in poor social functioning. A key process underlying social interactions is empathy: the ability to understand and share the perspectives and mental states of others. The current proposal divides empathy into two major components: affective empathy and cognitive empathy. Affective empathy might be relatively intact in schizophrenia and it involves vicariously sharing another person’s mental states. Affective empathy can be further divided into two subcomponents. Motor resonance refers to the brain’s tendency to activate the same regions during first-hand action as well as second-hand observation of motor movements. Associated brain regions include the inferior parietal lobule, posterior superior temporal sulcus, and inferior frontal gyrus. Affect sharing refers to overlapping activation of brain regions during first- and second-hand experience of emotion, and is associated with dorsal anterior cingulate cortex and anterior insula brain regions. Cognitive empathy involves taking the perspective of others, and ranges from simple visual perspective taking (inferring which objects someone sees from a different view point) to emotional perspective taking (more complex inferences about another’s feelings, beliefs, and intentions). It is consistently impaired in schizophrenia Cognitive empathy is associated with the medial prefrontal cortex, precuneus and temporo-parietal junction. The complex construct of empathy requires integration and coordination among regions within and between these brain networks. The network architecture underlying empathy in schizophrenia is not known, including any alterations in connections within and between regions of these empathy networks. The goal of this proposal is address this gap in the literature. To do so, the applicant will receive training in functional and structural brain connectivity methods and apply them to a multi-modal imaging study designed to better understand where empathy processing functions break down at the neural level in Veterans with schizophrenia. Acquiring the skills outlined in the training component will allow the applicant to utilize sophisticated, cutting-edge neuroimaging methods to conduct the next generation of translational neuroscience research on psychotic disorders. The primary mentor will be Michael F. Green, PhD, Director of the VISN 22 MIRECC Treatment Unit, an established leader in the field of schizophrenia research. The applicant will work with Dr. Green and three co-mentors who are experts in their respective fields, to learn skills necessary to analyze fMRI data for functional connectivity using multivariate techniques, dMRI data for structural connectivity, and apply graph theory, an advanced computational analysis, to the study of neural connectivity patterns. The work stands to make a significant contribution to the field by moving beyond a regional neural focus toward a neural network model of underlying mechanisms of psychopathology. The applicant’s career goal is to become a VA-based research psychologist, working to advance understanding of schizophrenia while also benefiting Veterans through practical application of research findings. This CDA will facilitate the applicant’s goal of independence, providing a unique combination of skills to become a local expert and long-term VA researcher. The applicant’s training environment at the VA MIRECC/UCLA provides an excellent environment and infrastructure from which to complete the proposed study.

社交互动是大多数人轻松导航的动态交流。 这些交流实际上是非常复杂的。 经常发现它们陷入困境，导致社会工作不良。 互动是同理心：理解和分享观点和精神状态的能力 当前的提议将同理心分为两个主要组成部分：情感 和认知的同理心。 涉及替代人分享另一个人的心理状态。 分为两个子组件。 第一手的同一区域以及运动运动的第一手观察。 相关的大脑区域包括较低的小叶，后颞上沟， 和下额的回旋。 第一手和二手情绪的经验，并且与背前扣带有关 皮质和前岛大脑区域。 其他人，范围从简单的视觉角度拍摄 从不同的观点）到情感的观点（关于 另一个人的感觉，信念和意义）。 移情与内侧前额叶皮层，前后和颞叶骨有关 交界处。 大脑网络内部和之间的区域。 在教育中尚不清楚，包括在 这些移情网络的区域。 文学作品。 连接方法并将其应用于旨在更好的多模式成像研究 了解同理心处理功能在退伍军人的神经水平上分解的地方 精神分裂症。 利用复杂的尖端神经影像学方法来进行下一代 关于精神病的转化神经科学研究。 F. Green，博士，VISN 22 MIRECC治疗部门的主任，您是您的成熟领导人 申请人的精神分裂症领域。 谁是各自领域的专家 使用多元技术的功能连接性，用于结构连接的DMRI数据， 将图理论（一种高级计算分析）应用于神经连接的研究 模式。 区域神经焦点朝着基础机制的神经网络模型 心理病理学。 努力提高对精神分裂症的理解，同时还通过 研究结果的实际应用。 独立，提供了成为本地专家和长期技能的独特组合 VA研究人员。 良好的环境环境和基础设施，可以从中完成支撑研究。