rTMS in alleviating Pain and Co-morbid symptoms in GWVI

rTMS 缓解 GWVI 的疼痛和共病症状

• 批准号: 10295159
• 负责人: DAVID J. CLARK
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-10-01 至 2025-09-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10295159
• 关键词: Address; Adopted; Analgesics; Anesthesia procedures; Antidepressive Agents; Arthralgia; Award; Brain region; Chronic Headaches; Clinical; Clinical Trials; Contralateral; Development; Diagnosis; Diffuse; Etiology; Evaluation; FDA approved; Functional disorder; Funding; Gulf War; Gulf War veteran; Hamilton Rating Scale for Depression; Headache; Investigation; Left; Location; Maintenance; Major Depressive Disorder; Mental Depression; Meta-Analysis; Migraine; Military Personnel; Motor Cortex; Multi-Institutional Clinical Trial; Myalgia; Narcotics; Neuronavigation; Neuropsychology; Pain; Pain management; Painless; Patients; Persian Gulf; Persian Gulf Syndrome; Pharmacological Treatment; Phase; Prefrontal Cortex; Prevalence; Prevention; Psychophysiologic Disorders; Quality of life; Randomized; Research; Severities; Site; Specificity; Symptoms; System; Transcranial magnetic stimulation; Treatment Efficacy; Treatment Protocols; Veterans; affective disturbance; associated symptom; brain magnetic resonance imaging; chronic pain; chronic pain patient; chronic painful condition; comorbidity; depressive symptoms; design; disabling symptom; efficacy evaluation; improved; innovation; mild traumatic brain injury; military veteran; pain relief; pain symptom; painful neuropathy; physical symptom; randomized controlled study; rehabilitation strategy; repetitive transcranial magnetic stimulation; sham-controlled study; side effect; treatment effect; treatment strategy

Abstract Headaches (HA), muscle and joint pain and depression are some of the most common debilitating symptoms in military personnel served in the 1990-1991 Persian Gulf War (GW1). Migraine like HA and diffuse body pain were detected in 64% of Gulf War Veteran (GWV) diagnosed with Gulf War Veterans’ Illnesses (GWVI). Likewise, depression carries a very high co- morbid prevalence (50%) in patients with chronic pain, and in GWV with GWVI related chronic HA, and body muscle and joint pain conditions (GWVI-HAP). Repetitive transcranial magnetic stimulation (rTMS) offers an effective non-invasive treatment option for GWVI-HAP. Our preliminary study funded by the DOD Innovation Treatment Evaluation Award for GWVI demonstrated that a short course (4 sessions) of rTMS at the motor cortex could significantly reduce GWI-HAP symptoms up to two months. This multi-center clinical trial study aims to further: 1) valid the long-term efficacy of the treatment for GWI-HAP and depression; and 2) assess site specificity of the treatment for both pain and depression. !

抽象的 头痛 (HA)、肌肉和关节疼痛以及抑郁是最常见的一些症状 1990-1991 年海湾战争 (GW1) 中服役的军事人员出现衰弱症状。 64% 的海湾战争退伍军人 (GWV) 检测到类似 HA 的偏头痛和弥漫性身体疼痛 被诊断患有海湾战争退伍军人疾病 (GWVI) 同样，抑郁症的发病率也很高。 慢性疼痛患者以及 GWV 与 GWVI 相关的慢性疼痛患者的病态患病率 (50%) HA，以及身体肌肉和关节疼痛状况（GWVI-HAP）。 刺激 (rTMS) 为 GWVI-HAP 提供了有效的非侵入性治疗选择。 初步研究由国防部 GWVI 创新治疗评估奖资助 证明运动皮层的 rTMS 短期课程（4 次）可以显着 减少 GWI-HAP 症状长达两个月。这项多中心临床试验研究旨在进一步： 1) 验证 GWI-HAP 和抑郁症治疗的长期疗效；2) 评估地点； 疼痛和抑郁治疗的特异性。 ！