Administrative Core

行政核心

基本信息

批准号：
10443846
负责人：
PENG JIN
金额：
$ 18.3万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-25 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10443846
关键词：
Accountability Adherence Back Biological Models Biomedical Engineering Brain California Collaborations Communication Communities Data Data Analyses Data Collection Deposition Development Disclosure Disputes Ensure FMRP Foundations Fragile X Syndrome Funding Gene Expression Regulation General Population Goals Human Human Resources Individual Information Dissemination Information Technology Infrastructure Institution Logistics Measurable Mediating Messenger RNA Molecular Monitor New York Pennsylvania Peripheral Persons Preparation Progress Reports Protocols documentation Regulation Research Research Personnel Research Project Grants Resource Sharing Resources Science Secure Site Sum System Testing Therapeutic Time Training Translational Regulation United States National Institutes of Health Universities cloud based community engagement data access data repository data resource data sharing data submission design innovation large datasets medical schools meetings member mouse model new therapeutic target novel novel therapeutics operation programs public repository relating to nervous system success synergism therapeutic development three-dimensional modeling tool

Accountability Adherence Back Biological Models Biomedical Engineering Brain California Collaborations Communication Communities Data Data Analyses Data Collection Deposition Development Disclosure Disputes Ensure FMRP Foundations Fragile X Syndrome Funding Gene Expression Regulation General Population Goals Human Human Resources Individual Information Dissemination Information Technology Infrastructure Institution Logistics Measurable Mediating Messenger RNA Molecular Monitor New York Pennsylvania Peripheral Persons Preparation Progress Reports Protocols documentation Regulation Research Research Personnel Research Project Grants Resource Sharing Resources Science Secure Site Sum System Testing Therapeutic Time Training Translational Regulation United States National Institutes of Health Universities cloud based community engagement data access data repository data resource data sharing data submission design innovation large datasets medical schools meetings member mouse model new therapeutic target novel novel therapeutics operation programs public repository relating to nervous system success synergism therapeutic development three-dimensional modeling tool

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项目摘要

Project Summary This multi-project Center aims to establish a framework to understand the FMRP-mediated regulation of human brain development and circuit functions at molecular, cellular and system circuitry levels using our established human 2D and 3D model systems as well as mouse models. The Center will test the overall hypothesis that FMRP regulates human brain development and circuit functions via translational regulation of novel mRNA targets, which could serve as new therapeutic targets for fragile X syndrome. Our proposed Center brings together an outstanding team of investigators from Emory University School of Medicine, Stanford University School of Medicine, New York University Center for Neural Science, University of Pennsylvania Perelman School of Medicine, and University of Southern California Department of Biomedical Engineering. Our investigators have had ongoing and productive collaborations with each other for many years and have been highly cooperative during the preparation of this application. The Administrative Core will serve as the foundation for a successful collaborative effort through centralized coordination of the proposed Projects and the leveraging of existing resources. A large collaborative research program such as this, which is designed to generate large datasets that need to be analyzed and integrated over research projects at multiple sites, requires a focused and dedicated effort to ensure success. The Administrative Core will assume primary responsibility for leading the effort to maintain transparency, organization, and communication. The Administrative Core will be responsible for facilitating the sharing of resources and data among investigators, ensuring timely progression towards milestones, sharing results with the scientific community and the general public, and conducting financial and regulatory oversight. We are committed to identifying innovative, state-of-the-art tools to facilitate this collaborative effort to reach our overarching goal. Using an array of collaborative organization products, we will be able to ensure open communication channels, secure sites for data deposition, and transparent operation of the Center. In summary, the Administrative Core is the foundation for a successful collaborative effort through centralized coordination of the proposed Projects and leverages existing resources within the partner institutions. Emory University, the host institution, offers a vast array of resources and expertise that we can access to facilitate the effective administration of this Center. We believe that our coordinated effort will create scientific synergy and significantly advance our understanding of FMRP-mediated gene regulation in human brain development and enable novel therapeutic development for fragile X syndrome.

项目摘要这个多项目中心旨在建立一个框架以了解FMRP介导的人类调节使用我们已建立的人类2D和3D模型系统以及小鼠模型。该中心将检验总体假设 FMRP通过新型mRNA的翻译调节来调节人脑发育和电路功能靶标，可以用作脆弱X综合征的新治疗靶标。我们提议的中心带来斯坦福大学埃默里大学医学院的一个杰出调查员团队纽约大学神经科学中心医学院，宾夕法尼亚大学佩雷曼学校医学和南加州大学生物医学工程系。我们的调查人员有多年来一直在持续且富有成效的合作，并且非常合作在准备此应用程序期间。行政核心将成为成功的基础通过集中协调拟议项目的协作努力和现有的利用资源。这样的大型协作研究计划，旨在生成大型数据集这需要在多个站点的研究项目上进行分析和集成，需要一个集中的和致力于确保成功的努力。行政核心将承担领导的主要责任努力保持透明度，组织和沟通。行政核心将负责促进研究人员之间资源和数据共享，以确保及时发展里程碑，与科学界和公众共享结果，并进行财务和监管监督。我们致力于确定创新的，最先进的工具来促进这一点协作努力实现我们的总体目标。使用一系列协作组织产品，我们将能够确保开放通信渠道，安全站点以进行数据沉积以及透明的操作中心。总而言之，行政核心是通过通过拟议项目的集中协调和利用合作伙伴机构内的现有资源。埃默里大学（Emory University），主机机构（Emory University）提供了各种各样的资源和专业知识促进该中心的有效管理。我们相信我们的协调努力将创造科学协同作用并显着提高我们对FMRP介导的人脑中基因调节的理解开发并实现了脆弱X综合征的新型治疗发展。