Consequences of Adolescent Alcohol Use on Brain Development

青少年饮酒对大脑发育的影响

基本信息

批准号：
8723602
负责人：
MARISA M SILVERI
金额：
$ 54.77万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-05 至 2019-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8723602
关键词：
Adolescent Adolescent Medicine Age Age of Onset Alcohol consumption Alcohol or Other Drugs use Anisotropy Anterior Behavior assessment Boston Brain Clinic Clinical Clinical assessments Cognitive Core-Binding Factor Data Development Diffusion Magnetic Resonance Imaging Drug usage Enrollment Failure Female Female Adolescents Foundations Functional Magnetic Resonance Imaging Glutamates Hippocampus (Brain)Hyperactive behavior Image Imaging Techniques Machine Learning Magnetic Resonance Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Adolescents Measurement Measures Medial Mediating Memory Methods Metric Modeling Multimodal Imaging Neuronal Plasticity New England Outcome Pattern Pediatric Hospitals Performance Perfusion Preventive Intervention Primary Health Care Process Recruitment Activity Relative (related person)Research Rest Sampling Signal Transduction Spin Labels Substance abuse problem Task Performances Temporal Lobe Time Visit adolescent alcohol adolescent substance abuse age related alcohol and other drug alcohol use initiation base blood oxygen level dependent cingulate cortex critical period design early alcohol use follow-up gamma-Aminobutyric Acid improved innovation insight male myelination neuroimaging neuropsychological pediatrician practice-based research network public health relevance reduce adolescent alcohol relating to nervous system response sex underage drinking way finding white matter

项目摘要

DESCRIPTION (provided by applicant): This revised R01 A1 proposal (AA022493), "Consequences of Adolescent Alcohol Use on Brain Development", responds to the need to understand the impact of initiating alcohol consumption on adolescent brain maturation. We have teamed with the Center for Adolescent Substance Abuse Research (CeASAR) and Boston Children's Hospital to implement an innovative strategy that combines multiple neuroimaging and neuropsychological approaches to identify neurodevelopmental vulnerabilities associated with early and escalating alcohol use during adolescence. Adolescents will be recruited from general pediatrician offices and adolescent medicine clinics comprising the New England Partnership for Substance Abuse Research (NEPSAR), a practice-based research network of primary care offices. Adolescents will be enrolled into the study prior to the initiation of alcoho use or other drug use, and examined longitudinally, at baseline (13-14 yrs old) and again at two annual follow-up visits. To provide a comprehensive longitudinal profile of brain function, structural magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), and task and resting state blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) will be paired with magnetic resonance spectroscopy (MRS) to measure GABA and glutamate levels in the anterior cingulate cortex (ACC) and medial temporal lobe (MTL, containing hippocampus). In addition, arterial spin labeling (ASL) will be used to measure quantitative perfusion, which will be used to calibrate the magnitude of BOLD fMRI signal changes during response inhibition and spatial memory fMRI tasks. Magnetic resonance measures will be integrated with measures from clinical assessments and an extensive neuropsychological battery, designed to detect and further characterize developmental changes and the influence of adolescent alcohol use. The incorporation of complementary multi-modal measures of brain function and neuroplasticity could offer valuable insight into the dynamic processes of brain maturation and help identify neural signatures associated with the onset and escalation of alcohol use, which will provide a foundation for informing prevention and intervention efforts aimed at reducing adolescent alcohol consumption.

描述（由申请人提供）：修订后的 R01 A1 提案 (AA022493)，“青少年饮酒对大脑发育的后果”，满足了了解开始饮酒对青少年大脑成熟的影响的需要。我们与青少年药物滥用研究中心 (CeASAR) 和波士顿儿童医院合作，实施一项创新策略，该策略结合了多种神经影像学和神经心理学方法，以识别与青春期早期和不断增加的饮酒相关的神经发育脆弱性。青少年将从普通儿科医生办公室和青少年医学诊所招募，这些诊所包括新英格兰药物滥用研究伙伴关系（NEPSAR），这是一个基于实践的初级保健办公室研究网络。青少年将在开始饮酒或使用其他药物之前被纳入研究，并在基线（13-14岁）和每年两次随访时进行纵向检查。为了提供脑功能的全面纵向概况，结构磁共振成像 (MRI)、扩散张量成像 (DTI) 以及任务和静息状态血氧水平依赖 (BOLD) 功能磁共振成像 (fMRI) 将与磁共振配对光谱（MRS）测量前扣带皮层（ACC）和内侧颞叶（MTL，包含海马）的 GABA 和谷氨酸水平。此外，动脉自旋标记（ASL）将用于测量定量灌注，这将用于校准反应抑制和空间记忆fMRI任务期间BOLD fMRI信号变化的幅度。磁共振测量将与临床评估和广泛的神经心理学测量相结合，旨在检测和进一步表征发育变化以及青少年饮酒的影响。结合大脑功能和神经可塑性的互补多模式测量可以为大脑成熟的动态过程提供有价值的见解，并帮助识别与酒精使用的开始和升级相关的神经特征，这将为预防和干预工作提供信息基础旨在减少青少年饮酒量。