Physiology-based virtual reality training for social skills in schizophrenia

基于生理学的虚拟现实精神分裂症社交技能训练

基本信息

批准号：
10229362
负责人：
SOHEE PARK
金额：
$ 53.2万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-03-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10229362
关键词：
Adherence Affect Affective Antipsychotic Agents Arousal Attention Behavioral Brain Clinical Cognitive Data Delusions Detection Devices Disease Dose Elements Emotions Environment Exercise Expert Systems Exposure to Eye Feedback Future Goals Hallucinations Impairment Individual Interpersonal Relations Intervention Lead Learning Life Measures Methods Nature Outcome Participant Patients Pattern Performance Persons Pharmacotherapy Phase Physiological Physiology Population Protocols documentation Psychological reinforcement Quality of life Randomized Randomized Controlled Trials Recovery Residual state Route Scanning Schizophrenia Signal Transduction Site Social Behavior Social Functioning Social Interaction Social outcome Social support Stimulus Stress Symptoms Technology Testing Time Training Training Activity Transferable Skills Work active control base cognitive function cognitive training compare effectiveness computerized conventional therapy cost design educational atmosphere effectiveness testing flexibility functional outcomes improved improved outcome indexing innovation meetings neural circuit novel novel strategies personalized learning portability psychosocial psychotic symptoms public health relevance recruit relating to nervous system remediation resilience response scaffold simulation skills skills training social social attention social cognition social deficits social interventions social skills social stress technological innovation time use virtual patient virtual reality virtual reality environment virtual reality game virtual reality intervention visual tracking

项目摘要

DESCRIPTION (provided by applicant): Social impairments are core features of schizophrenia that lead to poor outcome. Social skills and competence improve quality of life and protect against stress-related exacerbation of symptoms, while supporting resilience, interpersonal interactions, and social affiliation. To improve outcome, we must remediate social deficits. Existing psychosocial interventions are moderately effective but the effort-intensive nature (high burden), low adherence, and weak transfer of skills to everyday life present significant hurdles toward recovery. Thus, there is a dire need to develop effective, engaging and low-burden social interventions for people with schizophrenia that will result in better compliance rates and functional outcome. We will test the effectiveness of a novel adaptive virtual reality (VR) intervention in improving targeted social cognitive function (social attention as indexed by eye scanning patterns) in individuals with schizophrenia. VR technology offers a flexible alternative to conventional therapies, with several advantages, including a simplified and low-stress social interaction environment with targeted opportunities to simulate, exercise and reinforce basic elements of social skills in a very wide range of realistic scenarios, and to repea exposure to naturalistic situations from multiple angles. Our desktop VR `game' is designed as an `intelligent' system that adaptively adjusts the difficulty of social training tasks based on participant's physiological, eye tracking and performance data in real time. Such dynamic feedback-based, `closed-loop' VR supports and enhances training because it adjusts and personalizes the learning environment in real time for each participant so that he/she always learns at an optimal arousal and attentional state. Furthermore, the VR environment can potentially simulate any social scenarios, which allows the participants to exercise social skills n a wide variety of situations. Such simulation exercises can help generalize learned skills to everyday life. The R21 phase will aim to implement the social intervention VR task, test its efficacy on improving social attention (target) in schizophrenia, and determine an optimal `dose'. We hypothesize that the VR training will engage social attention and improving social attention will lead to better social outcome. The R33 phase will test the adaptive social VR game against an active control condition in a pilot randomized controlled trial to evaluate the relative efficac of the social VR on enhancing social attention and associated neural circuitry. We will also examine social outcome. If this initial work is successful, our long-term goals are to develop VR social skills training modules that are personalized, accessible, and portable so that social remediation can become an integral part of one's daily life.

描述（由适用提供）：社会障碍是精神分裂症的核心特征，导致结果不佳。社交技能和能力提高生活质量，并防止与压力相关的症状表现，同时支持韧性，人际关系互动和社会关联。为了改善结果，我们必须补救社会缺陷。现有的社会心理干预措施中等有效，但努力密集的性质（高燃烧），低粘附性和技能转移到日常生活中的薄弱是朝着康复的重大障碍。这是直接需要为精神分裂症患者开发有效，引人入胜且负担低的社会干预措施，这将导致更好的合规率和功能结果。我们将测试一种新颖的自适应虚拟现实（VR）干预措施在改善精神分裂症患者中的靶向社会认知功能（由眼睛扫描模式所索引）方面的有效性。 VR技术为传统疗法提供了一种灵活的替代方案，具有几个优势，包括简化和低压力社交互动环境具有针对性的机会，可以在非常广泛的现实情况下模拟，锻炼和加强社交技能的基本要素，并从多个角度重复接触自然主义情况。我们的桌面VR“游戏”被设计为“智能”系统，该系统根据参与者的生理，眼动跟踪和性能数据，可自适应地调整社交培训任务的困难。这种基于动态的反馈“闭环” VR支持和增强培训，因为它可以实时调整和个性化学习环境，以使每个参与者始终以最佳的唤醒和注意状态学习。此外，VR环境可能会模拟任何社交场景，从而使参与者能够行使社交技能和各种情况。这种模拟练习可以帮助将学习的技能推广到日常生活。 R21阶段将旨在执行社会干预VR任务，测试其在精神分裂症中改善社会关注（目标）的有效性，并确定最佳的“剂量”。我们假设VR培训将吸引社会关注，并提高社会关注将带来更好的社会成果。 R33阶段将在飞行员随机对照试验中测试自适应社会VR游戏，以评估社会VR对增强社会关注和相关神经电路的相对有效性。我们还将研究社会结果。如果这项最初的工作是成功的，那么我们的长期目标是开发个性化，可访问和便携的VR社交技能培训模块，以便社交补救可以成为人们日常生活中不可或缺的一部分。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Extraction of Emotional Information via Visual Scanning Patterns: A Feasibility Study of Participants with Schizophrenia and Neurotypical Individuals.

通过视觉扫描模式提取情感信息：精神分裂症和神经典型个体参与者的可行性研究。

DOI：
10.1145/3282434
发表时间：
2018
期刊：
ACM transactions on accessible computing
影响因子：
2.4
作者：
Wade,Joshua;Nichols,HeathmanS;Ichinose,Megan;Bian,Dayi;Bekele,Esube;Snodgress,Matthew;Amat,AshwaqZaini;Granholm,Eric;Park,Sohee;Sarkar,Nilanjan
通讯作者：
Sarkar,Nilanjan

Decoupling of spontaneous facial mimicry from emotion recognition in schizophrenia.

DOI：
10.1016/j.psychres.2019.03.035
发表时间：
2019-05
期刊：
Psychiatry research
影响因子：
11.3
作者：
Torregrossa LJ;Bian D;Wade J;Adery LH;Ichinose M;Nichols H;Bekele E;Sarkar N;Park S
通讯作者：
Park S

Improving treatments for psychotic disorders: beyond cognitive behaviour therapy for psychosis.

DOI：
10.1080/17522439.2020.1742200
发表时间：
2021
期刊：
Psychosis
影响因子：
1.2
作者：
Nelson B;Torregrossa L;Thompson A;Sass LA;Park S;Hartmann JA;McGorry PD;Alvarez-Jimenez M
通讯作者：
Alvarez-Jimenez M

Cross-cultural comparisons of psychosocial distress in the USA, South Korea, France, and Hong Kong during the initial phase of COVID-19.

DOI：
10.1016/j.psychres.2020.113593
发表时间：
2021-01
期刊：
Psychiatry research
影响因子：
11.3
作者：
Dean DJ;Tso IF;Giersch A;Lee HS;Baxter T;Griffith T;Song L;Park S
通讯作者：
Park S

The acceptability and feasibility of a novel virtual reality based social skills training game for schizophrenia: Preliminary findings.

DOI：
10.1016/j.psychres.2018.10.014
发表时间：
2018-12
期刊：
Psychiatry research
影响因子：
11.3
作者：
Adery LH;Ichinose M;Torregrossa LJ;Wade J;Nichols H;Bekele E;Bian D;Gizdic A;Granholm E;Sarkar N;Park S
通讯作者：
Park S