MIT Laser Biomedical Research Center

麻省理工学院激光生物医学研究中心

• 批准号: 10224755
• 负责人: Peter T. So
• 金额: $ 98.63万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10224755
• 关键词: Address; Area; Biological; Biological Sciences; Biomedical Research; Biophotonics; Biophysics; Cancer Biology; Cardiology; Chemistry; Clinic; Communicable Diseases; Communities; Complex; Contrast Media; Core Facility; Custom; Development; Diagnosis; Disclosure; Educational workshop; Engineering; Environment; Fluorescence Microscopy; Fluorescence Spectroscopy; General Hospitals; Goals; Hematology; Image; Imaging Device; Imaging technology; Institutes; Journals; Laboratories; Lasers; Lead; Leadership; Learning; Left; Legal patent; Massachusetts; Mechanics; Medical; Microscopy; Neurobiology; Oncology; Optics; Paper; Peer Review; Pharmacologic Substance; Program Development; Publishing; Quantum Dots; Raman Spectrum Analysis; Recording of previous events; Research; Research Personnel; Residencies; Resources; Running; Science; Scientist; Services; Spectrum Analysis; Surface; Techniques; Technology; Technology Transfer; Time; Training; United States National Institutes of Health; Universities; base; bioimaging; biological research; career; detection method; diagnostic technologies; fluorescence imaging; innovation; instrument; multiphoton microscopy; nanoprobe; nanoscale; new technology; next generation; photonics; physical science; practical application; program dissemination; programs; service programs; single molecule; spectroscopic imaging; stem cell biology; technology development; technology research and development; tool; webinar

MIT Laser Biomedical Research Center (LBRC) provides state-of-the-art integrative photonic solutions for the biomedical community. The LBRC core facilities sit within the G.R. Harrison Spectroscopy Laboratory, which has a century-long history of innovation and provides a dynamic environment for cutting-edge technology development. Continually rejuvenated by this setting, the LBRC develops and disseminates photonic solutions that address complex problems in biological research, pharmaceutical development, and medical diagnosis. The LBRC has served the nation's biological and medical community as a NIH research resource for almost 30 years, and during this time, the LBRC has enabled a diverse range of research, both fundamental science and practical applications, serving investigators from cancer biology, cardiology, infectious disease, hematology, stem cell biology, and neurobiology. We successfully developed a technology research and development (TRD) program to advance biomedical imaging and diagnostic technologies using on fluorescent, interferometric, and vibronic spectroscopies. We have a proven track-record of building fruitful partnerships, with over sixty of our collaborative projects (CPs) and service projects (SPs) achieving research milestones in the past 4 years. Quantitatively, during this period, we have published over 100 peer reviewed papers with many in high impact journals, filed 8 patent disclosures, started three companies, trained 15 center staffed who left LBRC with good careers, trained over 50 staff in our collaborators' laboratories, and disseminated technologies through organizing over 50 seminars distributing their content online. In the next cycle, LBRC leadership team has formulated an innovative and ambitious plan to substantially enhance our expertise base by expanding from three to seven senior investigators including: Dr. Peter So (Director) is an expert in nonlinear spectroscopy & microscopy, Dr. Ramachandra Dasari (Associate Director), an expert in Raman spectroscopy, Dr. Moungi Bawendi (Associated Director), an expert in quantum dot bioimaging, Dr. Gabriela Schlau-Cohen, an expert in single molecule biophysics and ultrafast spectroscopy. Dr. Ishan Barman, an expert in surface enhanced Raman spectroscopy, Dr. Conor Evans, an expert in nonlinear Raman spectroscopy, and Dr. Zahid Yaqoob, an expert in interferometric technology. We plan to go forward into the next cycle with four TRDs: (1) fluorescence spectroscopy and microscopy techniques, (2) interferometric spectroscopy and microscopy techniques, (3) Raman spectroscopy and microscopy techniques, and (4) Next-generation nanoprobe toolkit for biomedical applications. While NIH BTRCs cover a broad range of technologies, there is unmet demand for development of optical contrast agents and nanoscale probes. Establishing the new TRD4 on nanoprobes addresses this need and enables tight integration with unique spectroscopic detection methods developed in TRD1, 2, & 3. In association with these TRDs, we have further established 19 CPs and 19 SPs working with our collaborators on diverse areas of exciting biomedical research.

MIT激光生物医学研究中心（LBRC）为最先进的集成光子解决方案 生物医学界。 LBRC核心设施位于G.R.哈里森光谱实验室 一个世纪的创新历史，为尖端技术提供了动态的环境 发展。 LBRC不断通过这种设置恢复活力，开发并传播光子溶液 该解决了生物学研究，药物开发和医学诊断的复杂问题。这 LBRC将近30年的NIH研究资源服务为美国的生物学和医学界， 在此期间，LBRC使科学和实用性都可以进行多种研究 应用，癌症生物学，心脏病学，传染病，血液学，干细胞的研究人员 生物学和神经生物学。我们成功制定了技术研发（TRD）计划 在荧光，干涉和振动中推进生物医学成像和诊​​断技术 光谱学。我们拥有建立富有成果的合作伙伴关系的经验丰富的赛道，我们有60多个 在过去4年中，协作项目（CPS）和服务项目（SPS）实现了研究里程碑。 定量地，在此期间，我们发表了超过100份同行评审的论文，其中有很多影响力 期刊提交了8份专利披露，创办了三家公司，培训了15名中心人员，他们离开了LBRC良好 职业，在我们的合作者实验室中培训了50多名员工，并通过 组织50多个研讨会在线分发其内容。在下一个周期中，LBRC领导团队拥有 制定了一项创新且雄心勃勃的计划，以从 三到七名高级调查员包括：彼得·索（Peter So）博士（董事）是非线性光谱的专家 显微镜，拉曼光谱专家Ramachandra Dasari博士，Moungi博士 Bawendi（美联社），量子点生物影像学专家，Gabriela Schlau-Cohen博士，专家 单分子生物物理学和超快光谱法。 Ishan Barman博士，表面增强拉曼的专家 非线性拉曼光谱专家Conor Evans博士和专家Zahid Yaqoob博士 在干涉技术中。我们计划使用四个TRD进入下一个周期：（1）荧光 光谱和显微镜技术，（2）干涉光谱和显微镜技术，（3） 拉曼光谱和显微镜技术，以及（4）生物医学的下一代纳米探针工具包 申请。虽然NIH BTRC涵盖了广泛的技术，但对开发的需求未满足 光学对比剂和纳米级探针。在纳米探针上建立新的TRD4解决了这一需求 并可以与在TRD1、2和3中开发的独特光谱检测方法进行紧密整合。 与这些TRD相关联，我们进一步建立了19个CP和19个SPS与我们的合作者合作 令人兴奋的生物医学研究的不同领域。

项目成果

Mapping nanoscale topographic features in thick tissues with speckle diffraction tomography.

• DOI: 10.1038/s41377-023-01240-0
• 发表时间: 2023-08-22
• 期刊: LIGHT-SCIENCE & APPLICATIONS
• 影响因子: 19.4
• 作者: Kang, Sungsam;Zhou, Renjie;Brelen, Marten;Mak, Heather K.;Lin, Yuechuan;So, Peter T. C.;Yaqoob, Zahid
• 通讯作者: Yaqoob, Zahid

Initial findings of shortwave infrared otoscopy in a pediatric population.

短波红外耳镜检查在儿科人群中的初步发现。

• DOI: 10.1016/j.ijporl.2018.08.024
• 发表时间: 2018
• 期刊: International journal of pediatric otorhinolaryngology
• 影响因子: 1.5
• 作者: Valdez,TulioA;Carr,JessicaA;Kavanagh,KatherineR;Schwartz,Marissa;Blake,Danielle;Bruns,Oliver;Bawendi,Moungi
• 通讯作者: Bawendi,Moungi

Shedding Light on the Trehalose-Enabled Mucopermeation of Nanoparticles with Label-Free Raman Spectroscopy.

利用无标记拉曼光谱揭示海藻糖使纳米粒子的粘膜渗透性。

• DOI: 10.1002/smll.201901679
• 发表时间: 2019
• 期刊: Small (Weinheim an der Bergstrasse, Germany)
• 作者: Siddhanta,Soumik;Bhattacharjee,Sourav;Harrison,SabineM;Scholz,Dimitri;Barman,Ishan
• 通讯作者: Barman,Ishan

Early detection of high-grade squamous intraepithelial lesions in the cervix with quantitative spectroscopic imaging.

通过定量光谱成像早期检测宫颈高级鳞状上皮内病变。

• DOI: 10.1117/1.jbo.18.7.076013
• 发表时间: 2013
• 期刊: Journal of biomedical optics
• 影响因子: 3.5
• 作者: Lau,Condon;Mirkovic,Jelena;Yu,Chung-Chieh;O'Donoghue,GeoffP;Galindo,Luis;Dasari,Ramachandra;delasMorenas,Antonio;Feld,Michael;Stier,Elizabeth
• 通讯作者: Stier,Elizabeth

Depth resolved hyperspectral imaging spectrometer based on structured light illumination and Fourier transform interferometry.

基于结构光照明和傅里叶变换干涉测量的深度分辨高光谱成像光谱仪。

• DOI: 10.1364/boe.5.003494
• 发表时间: 2014
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Choi,Heejin;Wadduwage,Dushan;Matsudaira,PaulT;So,PeterTC
• 通讯作者: So,PeterTC