Cue Incubation in Substance Use Disorders: Validation and Assessment of Mechanisms

药物滥用障碍的线索孵化：机制的验证和评估

• 批准号: 10397679
• 负责人: Edward M. Bernat
• 金额: $ 19.31万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10397679
• 关键词: Abstinence; Affective; Alcohol consumption; Animals; Arousal; Attention; Base of the Brain; Behavioral; Biochemical; Blood; Brain-Derived Neurotrophic Factor; Clinic; Cocaine; Cocaine use disorder; Cues; Diagnosis; Disease; Drug Rehabilitation Centers; Drug usage; Electroencephalography; Environment; Etiology; Female; Future; Goals; Health; Human; Individual; Inpatients; Intervention; Interview; Laboratories; Measurement; Measures; Modeling; Nature; Negative Valence; Opioid; Participant; Patient Self-Report; Patients; Pattern; Peripheral; Pharmaceutical Preparations; Physiological; Positive Valence; Process; Rattus; Relapse; Research; Research Domain Criteria; Rewards; Sampling; Sex Differences; Site; Source; Substance Use Disorder; Symptoms; System; Testing; Validation; Work; base; cigarette smoking; cocaine relapse; cocaine use; craving; cue reactivity; design; drug craving; drug rehabilitation; executive function; follow-up; image processing; indexing; male; methamphetamine use; novel; recruit; relapse prediction; relapse risk; relating to nervous system; response; substance use; treatment program

PROJECT SUMMARY Substance cue-reactivity is a central process underlying patterns of substance use. Because it is associated with relapse, it is an important target for interventions. Mechanistic research in rats indicates that reactivity to drug cues increases across the first month of abstinence, often referred to as cue incubation. Cue incubation has recently been demonstrated in several studies with humans, with cigarette, alcohol, methamphetamine, and cocaine use. Importantly, the degree of cue incubation varies between individuals, and has been related to risk of relapse in rat models. Thus, cue incubation may represent a critical process indexing vulnerabilities to relapse for humans in the early stages of drug use cessation. Further work is needed to assess this important source of variance in cue-reactivity with humans, and develop novel targets for intervention during this vulnerable period. Approach. In this study we will test for cue incubation in a sample of inpatients with cocaine use disorder in a residential drug-rehabilitation center. Primary measures of incubation will include self-report measures of craving, EEG-based late positive potential (LPP; indexing attentional engagement), and blood-based brain derived neurotrophic factor (BDNF; a well-validated measure of cue incubation in rats, indexing negative valence system engagement). We will include additional measures of candidate mechanisms underlying cue incubation based on the Research Domain Criteria (RDoC) framework, including control (executive function), arousal, and positive and negative valence systems (e.g. reward and loss processing, response inhibition and execution, and affective image processing). Goal. The proposed work will examine cue incubation in humans with cocaine use disorder. We will measure incubation at subjective, behavioral, neural, and biochemical levels, and include sufficient numbers of participants to examine predictors of incubation across individuals. These studies will provide a critical bridge between animal and human studies of incubation, and novel, comprehensive, information about candidate processes underlying cue incubation in humans – with the goal of advancing the utility of the cue incubation hypothesis in etiologic and intervention work with humans.

项目摘要 物质提示反应性是一种使用物质使用模式的基础过程。 复发，这是国际的重要目标。 提示在节制的第一个蒙特斯上增加，提示孵育。 最近在与人类，香烟，酒精，甲基苯丙胺和 可卡因使用。 大鼠模型中的复发。 在药物使用停止的早期阶段人类。 提示与人类反应的差异，并在脆弱时期开发针对干预目标的小说。 在这项研究中，我们将在可卡因使用障碍的样本中测试提示提示 居住药物理化中心。 渴望，基于脑电图的晚期积极潜力（LPP；索引同性恋参与）和血液 - 大脑 衍生的神经营养因子（BDNF；在大鼠中孵育的提示孵化的验证良好 系统参与）。 基于研究领域标准（RDOC）框架，包含控制（执行功能），唤醒和 正价和负价系统（例如奖励和损失处理，响应侵犯和执行 情感图像处理）。 疾病。 足够数量的参与者检查这些研究的预测因子 提供动物和人类孵化之间的关键桥梁，以及11月，全面的信息 关于候选过程起诉人类的孵化 - 目的是推进效用。 病因和相互作用中的提示孵育假设与人类。