Measuring Altered Glutathione in Children with Autism Spectrum Disorder

测量自闭症谱系障碍儿童的改变谷胱甘肽

基本信息

批准号：
10223398
负责人：
Richard Anthony Edward Edden
金额：
$ 20.34万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-24 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10223398
关键词：
Affect Antioxidants Apoptosis Brain Brain region Child Cognition Cognitive Cognitive deficits DNA Repair Data Development Disease Early Intervention Environmental Risk Factor Family Free Radicals Functional disorder Future Genetic Glutathione Glutathione Disulfide Goals Grant Health Healthcare Systems Heterogeneity Human Impaired cognition Impairment Individual Individual Differences Lead Life Magnetic Resonance Spectroscopy Maintenance Measurement Measures Medial Metabolic Methods Mind Motor Neurologic Deficit Neurologic Examination Neurons Neurotransmitters Nitric Oxide Oxidation-Reduction Oxidative Stress Oxides Peripheral Physical Examination Plasma Play Prefrontal Cortex Process Reactive Oxygen Species Regulation Resolution Role Severities Signal Transduction Techniques Testing Work autism diagnostic observation schedule autism spectrum disorder autistic children behavior measurement behavioral outcome cell injury cohort developmental disease dimer experimental study functional disability gamma-Aminobutyric Acid in vivo innovation neuropathology neurophysiology neurotransmission novel peripheral blood prevent repetitive behavior social theories

项目摘要

Project summary Autism Spectrum Disorder (ASD) is characterized by impairments in social and communicative function and repetitive behaviors. Recent work suggests that oxidative stress (arising from both genetic and environmental causes) is a contributing factor to the neuropathology of ASD. Emerging evidence suggests that increased oxidative stress may contribute to the neuronal and cognitive impairments seen in children with Autism Spectrum Disorder (ASD). Glutathione (GSH) is the main redox compound in the brain, and reduced GSH during development may lead to such increases in oxidative stress and may be a primary cause of secondary neurophysiological impairments in ASD. GSH can be measured using edited Magnetic Resonance Spectroscopy (MRS). Here, we propose using a highly novel MRS technique (HERMES) to measure GSH in the brain of children with ASD and investigate its relation to functional behavioral measures of autism, and peripheral markers of oxidative stress, work not previously performed. The novelty lies in the application in children, using a recently developed, more specific and valid MRS technique. Increased oxidative stress, and associated GSH dysfunction, may therefore be an important contributor to autism-associated alterations in brain development, contributing in turn to cognitive and social impairments common in ASD. Understanding the role of oxidative stress in ASD is important for understanding the emergence of ASD and offers a promising target for future early interventions to increase GSH concentration in the brain.

项目摘要自闭症谱系障碍（ASD）的特征是社会和沟通功能的障碍和重复行为。最近的工作表明氧化应激（均由遗传和环境引起原因）是ASD神经病理学的一个促成因素。新兴证据表明增加氧化应激可能有助于自闭症儿童中看到的神经元和认知障碍频谱障碍（ASD）。谷胱甘肽（GSH）是大脑中的主要氧化还原化合物，并减少了GSH 在发育过程中可能导致氧化应激的增加，这可能是继发性的主要原因 ASD的神经生理障碍。可以使用编辑的磁共振来测量GSH 光谱法（MRS）。在这里，我们建议使用高度新颖的MRS技术（Hermes）测量GSH ASD儿童的大脑，并调查其与自闭症的功能行为度量的关系，氧化应激的外围标记，以前没有进行工作。新颖性在于应用使用最近开发，更具体和有效的MRS技术的孩子。氧化应激增加，并且因此，相关的GSH功能障碍可能是自闭症相关改变的重要贡献大脑发育，反过来促进了ASD常见的认知和社会障碍。理解氧化应激在ASD中的作用对于理解ASD的出现很重要，并提供了未来早期干预措施的有希望的目标，以增加大脑中的GSH浓度。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Edited magnetic resonance spectroscopy in the neonatal brain.

编辑了新生儿大脑的磁共振波谱。

DOI：
10.1007/s00234-021-02821-9
发表时间：
2022-03
期刊：
Neuroradiology
影响因子：
2.8
作者：
Song Y;Lally PJ;Yanez Lopez M;Oeltzschner G;Nebel MB;Gagoski B;Kecskemeti S;Hui SCN;Zöllner HJ;Shukla D;Arichi T;De Vita E;Yedavalli V;Thayyil S;Fallin D;Dean DC 3rd;Grant PE;Wisnowski JL;Edden RAE
通讯作者：
Edden RAE

The trajectory of cortical GABA across the lifespan, an individual participant data meta-analysis of edited MRS studies.

DOI：
10.7554/elife.62575
发表时间：
2021-06-01
期刊：
eLife
影响因子：
7.7
作者：
Porges EC;Jensen G;Foster B;Edden RA;Puts NA
通讯作者：
Puts NA

The macromolecular MR spectrum does not change with healthy aging.

DOI：
10.1002/mrm.29093
发表时间：
2022-04
期刊：
Magnetic resonance in medicine
影响因子：
3.3
作者：
Hui SCN;Gong T;Zöllner HJ;Song Y;Murali-Manohar S;Oeltzschner G;Mikkelsen M;Tapper S;Chen Y;Saleh MG;Porges EC;Chen W;Wang G;Edden RAE
通讯作者：
Edden RAE

Comparison of seven modelling algorithms for γ-aminobutyric acid-edited proton magnetic resonance spectroscopy.