Noninvasive modulation of perception and cognition with flicker induced response modulation.

通过闪烁引起的响应调制对感知和认知进行无创调制。

• 批准号: 10222897
• 负责人: Bart Krekelberg
• 金额: $ 39.21万
• 依托单位: RUTGERS THE STATE UNIV OF NJ NEWARK
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10222897
• 关键词: Amblyopia; Area; Attention; Behavioral; Brain; Chemosensitization; Cognition; Cognitive deficits; Computer Models; Contrast Sensitivity; Data; Detection; Elderly; Electroencephalography; Frequencies; Goals; Health; Hour; Human; Human Volunteers; Laboratories; Lead; Methods; Modeling; Neurons; Occipital lobe; Parietal; Patients; Pattern; Perception; Performance; Photic Stimulation; Research; Rodent; Short-Term Memory; Specificity; Techniques; Testing; Therapeutic Uses; V1 neuron; Vision; Visual; Visual Acuity; Visual Cortex; Visual impairment; Visuospatial; base; clinically relevant; density; experimental study; extracellular; human subject; improved; insight; luminance; neuropsychiatric disorder; neuropsychiatry; neuroregulation; nonhuman primate; recruit; recurrent neural network; relating to nervous system; response; spatial integration; tool; visual cognition; visual process; visual processing; visual stimulus

Project Summary This project investigates the use of repetitive visual stimulation as a tool to improve visual cognition. Surprisingly, the repeated presentation of simple visual patterns can result in long-term plasticity, reflected in increased neural responses, but also in behavioral improvements that last for hours, even days. In current approaches using RVS, however, these improvements are limited to the specific, repeated patterns; this limits the practical usefulness of RVS. The proposed project builds on recent findings in the nonhuman primate demonstrating widespread and general increases in neural responses after the repeated presentation of a uniform grey screen with sinusoidally modulated luminance. The first aim is to show, using EEG, that such long-lasting increases in neural responses also occur in the human brain. The second aim is to determine which aspects of visual cognition are improved by this boost in neural responses. The project will assess improvements in low-level vision such as detection and visual acuity, but also higher-level visual processes such as visuospatial attention, and visual working memory. The pilot data already show widespread neural changes in the human brain and substantial behavioral improvements in, for instance, visual acuity. A successful tool to improve visual cognition would have a significant impact, as it could be used therapeutically in low vision conditions (e.g., amblyopia), but also in the elderly or healthy human subjects, to deliver a boost in performance.

项目摘要 该项目调查了重复视觉刺激的使用作为改善视觉认知的工具。出奇， 简单视觉模式的重复表示可能导致长期可塑性，反映在增加的神经 响应，但在行为改进中持续数小时甚至几天。在当前使用RVS的方法中， 但是，这些改进仅限于特定的重复模式。这限制了实际实用性 RV。拟议的项目以非人类灵长类动物的最新发现为基础，证明了广泛的 在重复呈现均匀的灰屏呈正弦的均匀灰色屏幕后，神经反应的总体增加 调制亮度。第一个目的是使用脑电图表明神经反应的持久增加 也发生在人脑中。第二个目的是确定改善视觉认知的哪些方面 通过这种增强神经反应。该项目将评估低级视觉的改进，例如检测 和视敏度，以及更高级别的视觉过程，例如视觉空间注意力和视觉工作 记忆。试验数据已经显示出人脑的广泛神经变化和实质性行为 例如，视力改善。改善视觉认知的成功工具将具有重要的 影响，因为它可以在低视力条件下（例如弱视）进行治疗，但也可以在老年人或老年人或 健康的人类受试者，以提高性能。