Real-time in vivo proton range verification in proton therapy with thallium bromide detectors

使用溴化铊探测器进行质子治疗中的实时体内质子范围验证

基本信息

批准号：
10390443
负责人：
Gerard Ariño Estrada
金额：
$ 69.36万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-15 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10390443
关键词：
3-Dimensional Address Anodes Biomedical Engineering Body Regions Bromides Cancerous Charge Clinical Collimator Crystallization Cyclotrons Data Set Deposition Detection Devices Digital Signal Processing Dimensions Dose Electrodes Electrons Face Film Gamma Rays Goals Gold Head and Neck Cancer Head and neck structure Health Services Accessibility Healthcare Heterogeneity Image Laboratories Length Letters Light Liver Location Lung Methods Modeling Monitor Motion Nature Nuclear Operative Surgical Procedures Organ Outcome Parents Patients Performance Photons Positioning Attribute Protons Radiation Radiation Dose Unit Radiation therapy Radioactive Research Project Grants Resolution Risk Scanning Semiconductors Silicon Source Spectrum Analysis Surface Techniques Testing Thallium Time Tissues Toxic effect Treatment Efficacy Treatment Protocols Uncertainty Work X-Ray Computed Tomography attenuation base beamline cancer therapy conventional therapy density detection platform detector falls feasibility testing improved in vivo instrumentation nanosecond novel operation particle photomultiplier photonics preservation printed circuit board proton beam proton therapy prototype real time monitoring respiratory response seal signal processing tumor

3-Dimensional Address Anodes Biomedical Engineering Body Regions Bromides Cancerous Charge Clinical Collimator Crystallization Cyclotrons Data Set Deposition Detection Devices Digital Signal Processing Dimensions Dose Electrodes Electrons Face Film Gamma Rays Goals Gold Head and Neck Cancer Head and neck structure Health Services Accessibility Healthcare Heterogeneity Image Laboratories Length Letters Light Liver Location Lung Methods Modeling Monitor Motion Nature Nuclear Operative Surgical Procedures Organ Outcome Parents Patients Performance Photons Positioning Attribute Protons Radiation Radiation Dose Unit Radiation therapy Radioactive Research Project Grants Resolution Risk Scanning Semiconductors Silicon Source Spectrum Analysis Surface Techniques Testing Thallium Time Tissues Toxic effect Treatment Efficacy Treatment Protocols Uncertainty Work X-Ray Computed Tomography attenuation base beamline cancer therapy conventional therapy density detection platform detector falls feasibility testing improved in vivo instrumentation nanosecond novel operation particle photomultiplier photonics preservation printed circuit board proton beam proton therapy prototype real time monitoring respiratory response seal signal processing tumor

展开

项目摘要

Summary Radiotherapy using protons is an attractive option as it has the potential to better preserve healthy tissue compared to radiation with photons or electrons, and because trial outcomes indicate it can replace surgery for radical cancer treatments as well. Proton therapy makes use of the finite range of heavy charged particles with an intensity maximum at the end of their path (Bragg peak) followed by a sharp fall-off of the dose. However, predicting the proton range based on computed tomography (CT) scans carries an estimation uncertainty. For treatments with proximal critical organs and limited accessibility (head and neck), high heterogeneities (lung), or significant breath motion (liver) such uncertainty is too high and the therapy is in the best case challenging, if not impossible. New instrumentation is needed to monitor the location of the Bragg peak to 1-2 mm accuracy within several seconds in these challenging scenarios. We propose to use the novel Cerenkov Charge Induction (CCI) thallium bromide (TlBr) detectors for proton range verification (PRV) in proton therapy. CCI TlBr detectors combine the detection of Cerenkov light, which provides sub-nanosecond timing resolution with the conventional readout of semiconductor detectors, which provides excellent energy resolution and 3-D segmentation. Moreover, TlBr has a shorter attenuation length than most commonly used scintillation materials for prompt-gammas up to 6.1 MeV. CCI TlBr detectors provide a unique performance, as they offer simultaneous excellent performance in energy, time, and spatial resolution, that fits the needs of PRV in proton therapy. In this project, we will test the feasibility of using a non-collimated prompt gamma timing – Compton camera (PGT-CC) camera based on pixel CCI TlBr detectors for PRV in proton therapy. We will 1) manufacture pixel CCI TlBr detectors with optimized surface treatment to couple the photodetector and with highly-stable long- lasting electrodes; 2) characterize the detector features of pixel CCI TlBr devices in a benchtop setting using sealed sources, including energy, spatial, and timing resolution; 3) evaluate the performance of a PGT-CC camera for PRV made with pixel CCI TlBr detectors in a beamline with protons accelerated to 67.5 MeV; and 4) compare the performance of our PGT-CC camera prototype with gold standard techniques following realistic treatment protocols at a clinical beamline with protons accelerated to >200 MeV. The accomplishment of the aims of this project will determine the potential of CCI TlBr detectors to become the most competitive devices for PRV in proton therapy. A successful performance of the proposed detection system would allow to exploit the benefits of proton therapy in treatment regions that are currently very challenging, leading to increased treatment efficacy and lower toxicity in the healthy organs of the patients.

概括使用质子的放射疗法是一个有吸引力的选择，因为它具有更好地保存健康组织的潜力与照片或电子的辐射相比，并且由于试验结果表明它可以取代手术根治性的癌症治疗。质子疗法利用有限的重电颗粒与路径末端的强度最大值（布拉格峰），然后是剂量的急剧下降。然而，根据计算机断层扫描（CT）扫描预测质子范围具有估计不确定性。为了近端临界器官和有限的可及性（头颈），高异质性（肺）治疗，或大量呼气运动（肝）这种不确定性太高，并且在最好的情况下，治疗是最好的情况挑战并非不可能。需要新的仪器来监视布拉格峰的位置至1-2毫米的精度在这些挑战场景中的几秒钟内。我们建议使用新型的Cerenkov电荷诱导（CCI）溴化thallium溴化物（TLBR）检测器质子治疗中的范围验证（PRV）。 CCI TLBR探测器结合了Cerenkov Light的检测通过传统的半导体检测器读数提供子纳秒的时间分辨率，该探测器的常规读数提供出色的能量分辨率和3D分割。此外，TLBR的衰减长度较短比大多数常用的闪烁材料用于6.1 MeV的及时速度。 CCI TLBR探测器提供独特的性能，因为它们在能量，时间和空间方面提供了简单的出色表现解决方案，适合PRV在质子疗法中的需求。在这个项目中，我们将测试使用未填充的及时伽马计时的可行性 - 康普顿摄像头（PGT-CC）基于质子治疗中PRV的像素CCI TLBR探测器的相机。我们将1）制造像素 CCI TLBR探测器具有优化的表面处理，以对光电探测器进行杂交，并具有高稳定的长长持久电极； 2）在台式设置中使用Pixel CCI TLBR设备的检测器特征使用密封的来源，包括能量，空间和定时分辨率； 3）评估PGT-CC的性能用像素CCI TLBR探测器制成的PRV摄像机，质子加速至67.5 MeV；和 4）将我们的PGT-CC摄像机原型的性能与金标准技术进行了比较临床梁线上的治疗方案加速> 200 meV。该项目目标的实现将决定CCI TLBR探测器成为质子治疗中PRV的最有竞争力的设备。拟议检测的成功表现系统将允许利用目前非常非常非常具有挑战性，导致治疗效率提高和患者健康器官的毒性降低。