The impact of sleep on memory selectivity and problem solving: Common and distinct neural mechanisms

睡眠对记忆选择性和问题解决的影响：常见和独特的神经机制

• 批准号: 10389168
• 负责人: Kristin Sanders
• 金额: $ 6.76万
• 依托单位: UNIVERSITY OF NOTRE DAME
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2025-09-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10389168
• 关键词: Address; Adult; Affect; Age; Anxiety; Applications Grants; Area; Brain; Cognition; Cognitive; Cognitive deficits; Communication Research; Complex; Coupling; Cues; Detection; Development; Educational workshop; Electroencephalography; Emotional; Fellowship; Foundations; Future; Hour; Impairment; Knowledge; Laboratories; Learning; Link; Medical; Memory; Mental Depression; Mental disorders; Mentorship; Neurosciences; Participant; Personal Satisfaction; Persons; Polysomnography; Post-Traumatic Stress Disorders; Problem Solving; Process; Publications; REM Sleep; Research; Research Ethics; Research Personnel; Research Proposals; Rewards; Role; Sleep; Sleep Stages; Sleep disturbances; Solid; Specificity; Techniques; Testing; Time; Training; awake; career; clinical diagnosis; cognitive neuroscience; experience; experimental study; meetings; memory consolidation; memory process; neural correlate; neuromechanism; non rapid eye movement; novel; power analysis; relating to nervous system; skills; sleep spindle; sound; young adult

Sleep is important for cognitive well-being, yet many adults do not get enough sleep. Sleep is especially important for selectively strengthening memories that are emotionally salient, associated with rewards, and relevant for future use; and sleep’s effect on memory selectivity may exacerbate some mental disorders. However, the neural mechanisms of sleep-facilitated selectivity are still being identified, and whether the same mechanisms generalize across different cognitive domains such as emotional memory and problem solving is unknown. The current research will examine 1) the interaction and unique contribution of sleep to emotional memory selectivity and problem solving; 2) the neural signatures of sleep’s effect on selectivity; and 3) whether targeted memory reactivation during rapid eye movement sleep similarly facilitates emotional memory selectivity and problem solving. We will record participants’ brain activity using EEG while they sleep in one of four state-of-the-art laboratory bedrooms, allowing us to precisely identify participants’ sleep stages and associated neural signatures. This research will lead to a better understanding of the neural mechanisms of sleep’s effect on cognition, allowing future research to examine the effect of sleep disruption on sleep-facilitated selectivity. The fellowship training plan will enable the applicant to conduct the proposed research and prepare her for a future career as an independent researcher. Through coursework, workshops, and mentorship, the applicant will extend her prior training in problem solving to include expertise in the cognitive neuroscience of sleep and memory, including EEG analysis techniques such as spectral power analysis, sleep spindle detection, and slow- oscillation-spindle coupling. In addition, the training plan provides extensive professional development in areas of academic communication, research management, and research ethics. Results from the proposed research will be widely disseminated in scientific meetings and publications, and will inform novel research questions at the intersection of sleep, memory, and problem solving, providing a solid foundation from which the applicant can launch her independent research career.

睡眠对于认知健康很重要，但是许多成年人没有足够的睡眠。睡眠是 对于有选择地加强情感上突出的记忆特别重要， 与奖励相关，与将来使用相关；睡眠对记忆选择性的影响 可能会加剧一些精神障碍。但是，睡眠方面的神经元机制 选择性仍在确定，以及相同的机制是否跨越 不同的认知领域（例如情绪记忆和解决问题）尚不清楚。这 当前的研究将检查1）睡眠对情感的互动和独特的贡献 记忆选择性和解决问题； 2）睡眠对选择性影响的神经特征； 3）在快速眼动过程中，靶向记忆重新激活是否类似 促进情绪记忆的选择性和解决问题。我们将记录参与者的大脑 脑电图在四个最先进的实验室卧室之一中睡觉时使用脑电图的活动，允许 我们准确地确定参与者的睡眠阶段和相关的神经信号。这 研究将使对睡眠对神经机制的影响更好地理解 认知，允许未来的研究检查睡眠中断对睡眠促成的影响 选择性。奖学金培训计划将使申请人能够进行拟议的 研究并为她做好准备，使她成为独立研究人员的未来职业。通过 课程工作，讲习班和精神训练，申请人将扩大她先前的问题培训 解决以在内的睡眠和记忆的认知神经科学中包括专业知识，包括脑电图 分析技术，例如光谱功率分析，睡眠主轴检测和慢速 - 振荡主轴耦合。此外，培训计划提供了广泛的专业人士 在学术沟通，研究管理和研究道德领域的发展。 拟议研究的结果将在科学会议上广泛传播 出版物，并将在睡眠，记忆和 解决问题，为申请人可以发射她的坚实基础 独立研究职业。