Bioinformatics and Modeling Core

生物信息学和建模核心

• 批准号: 10378122
• 负责人: Srinivas Ravi V Iyengar
• 金额: $ 23.79万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10378122
• 关键词: Acute; Aneurysm; Angiotensin II; Bioinformatics; Biological; Blood Pressure; Caring; Cell Adhesion; Cell Communication; Cell physiology; Cells; Chemicals; Computer Analysis; Computer Models; Data; Differential Equation; Disease; Dissection; Drug Targeting; ECM receptor; Endothelial Cells; Endothelium; Ensure; Environment; Extracellular Matrix; Feedback; Gene Expression Profiling; Genes; Genetic; Goals; Individual; Integrins; Knowledge; Measurement; Mechanics; Modeling; Molecular; Mouse Protein; Mus; Mutation; Output; Pathway Analysis; Pathway interactions; Proteins; Reaction; Regulatory Pathway; Seeds; Signal Transduction; Smooth Muscle Myocytes; Standardization; Statistical Data Interpretation; Study models; System; Testing; Therapeutic Intervention; Thoracic Aortic Aneurysm; Time; Tissues; Transforming Growth Factor beta; Variant; Vascular Smooth Muscle; base; differential expression; dynamic system; experimental study; graph theory; insight; interest; mRNA sequencing; mechanical force; mechanical signal; mechanotransduction; model building; model development; mouse model; novel; pressure; protein protein interaction; receptor; response; shear stress; spatial relationship; therapeutic target; transcriptomics; virtual

The overall significance of Core B is that it will provide standardized and rigorous bioinformatics and computational modeling analyses of all the molecular changes that occur in thoracic aortic aneurysms. Such analyses will allow each of the projects to develop a mechanistic understanding of the molecular changes that occur and how these changes contribute to the progression towards dissection. We anticipate such integrated analyses will help us deconvolute how multiple chemical signals as well as physical forces interact to control functions in the cells of the vessel wall during disease origin and progression.

Core B的总体意义在于它将提供标准化和严格的生物信息学 胸主动脉发生的所有分子变化的计算模型分析 动脉瘤。此类分析将使每个项目都能够开发出一种机制 了解发生的分子变化以及这些变化如何促进 向解剖进展。我们预计这种综合分析将帮助我们解开谜团 多种化学信号和物理力如何相互作用来控制细胞功能 疾病起源和进展期间血管壁的变化。