Administrative Core

行政核心

基本信息

批准号：
10204118
负责人：
Pamela J Lein
金额：
$ 27.48万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10204118
关键词：
Acute Advanced Development Advisory Committees Anticonvulsants Calendar Chemicals Cholinesterase Inhibitors Collaborations Committee Members Communication Communities Data Database Management Systems Development Educational workshop Ensure Environmental Health Equipment and supply inventories Event Federal Government Fostering Funding General Population Goals Government Agencies Grant Human Resources IACUC Intellectual Property Intoxication Investigational Drugs Isoflurophate Laboratories Lead Leadership Legal patent Logistics Manuscripts Medical Research Mission Monitor Online Systems Organophosphates Paraoxon Picrotoxin Policies Procedures Protocols documentation PubMed Readiness Reagent Regulation Reporting Research Research Activity Research Institute Research Personnel Research Project Grants Resource Sharing Role Safety Secure Security Seizures Series Soman Strategic Planning System Technology Transfer Therapeutic Therapeutic Agents TimeLine Training United States Food and Drug Administration United States National Institutes of Health Universities Work authority central database chemical threat data exchange data management data sharing education research improved interest medical countermeasure meetings novel operation prevent programs receptor research and development statistics success synergism tetramethylenedisulfotetramine therapeutic development web site

项目摘要

Project Summary – Administrative Core The overall goal of the UC Davis CounterACT Center of Excellence is to identify and advance improved medical countermeasures for stopping seizures and preventing long-term consequences of acute intoxication with chemical threat agents, specifically organophosphate cholinesterase inhibitors like diisopropylfluorophosphate (DFP), paraoxon and soman, or GABAA receptor blockers like tetramethylenedisulfotetramine (TETS) and picrotoxin. The UC Davis CounterACT Center comprises three projects, three scientific cores, a research education core and multiple committees — all of which must work closely together to ensure success. The role of the Administrative Core is to oversee and coordinate the scientific and administrative operations of the Center's activities and to foster interactions and synergism among Center research projects and scientific cores, ultimately ensuring the Center meets annual milestones established in collaboration with NIH CounterACT program officer(s). Additionally, the Administrative Core will coordinate interactions with the UC Davis administration and external entities, such as the NIH CounterACT administration, the Center's External Advisory Committee, the larger CounterACT research community, the U.S. Food and Drug Administration (FDA), the Biomedical Advanced Research and Development Authority (BARDA), and commercial partners. The Core's objectives are: (1) Develop a strategic plan for achieving annual Center milestones and ensure its effective and efficient implementation; (2) Provide scientific leadership and logistical support to coordinate and integrate Center activities and promote interactions among Center investigators; (3) Facilitate data and resource sharing among Center investigators and other CounterACT investigators; (4) Provide budgetary oversight and grant management; (5) Ensure the safety and security of personnel, materials, data and facilities; (6) Coordinate the development of intellectual property (IP) strategies and the transitioning of leads for advanced development; (7) Coordinate with FDA, BARDA and other federal government agencies; and (8) Identify, engage and coordinate communications with commercial partners.

项目摘要 - 行政核心加州大学戴维斯分校卓越卓越中心的总体目标是识别和提高医疗与制止癫痫发作和防止急性中毒的长期后果的对策化学威胁剂，特别是有机磷酸盐胆碱酯酶抑制剂，如二异丙氟磷酸盐（DFP），副支持者和SOMAN或GABAA受体阻滞剂，例如四甲基二硫胺（TET）和野毒素。加州大学戴维斯分校的抵抗中心包括三个项目，三个科学核心，一项研究教育核心和多个委员会 - 所有这些都必须紧密合作，以确保成功。角色行政核心是监督和协调的科学和行政操作中心的活动以及中心研究项目和科学核心之间的互动和协同作用，最终确保该中心达到与NIH Counter合作建立的年度里程碑计划官员。此外，管理核心将协调与UC Davis的互动管理和外部实体，例如NIH抵抗管理，该中心的外部咨询委员会，较大的抵抗研究社区，美国食品药品监督管理局（FDA），生物医学高级研发局（Barda）和商业合作伙伴。核心的目标是：（1）制定一项战略计划，以实现年度中心里程碑，并确保其有效和有效的实施；（2）提供科学领导和后勤支持以协调和整合中心活动并促进中心研究人员之间的互动；（3）促进数据和资源共享在中心调查人员和其他反对研究人员中；（4）提供预算监督和赠款管理; （5）确保人员，材料，数据和设施的安全性；（6）协调知识产权（IP）策略的发展和高级发展的线索过渡；（7）与FDA，Barda和其他联邦政府机构进行协调；（8）识别，参与和协调与商业合作伙伴的沟通。