Administrative Core

行政核心

基本信息

批准号：
10204118
负责人：
Pamela J Lein
金额：
$ 27.48万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10204118
关键词：
Acute Advanced Development Advisory Committees Anticonvulsants Calendar Chemicals Cholinesterase Inhibitors Collaborations Committee Members Communication Communities Data Database Management Systems Development Educational workshop Ensure Environmental Health Equipment and supply inventories Event Federal Government Fostering Funding General Population Goals Government Agencies Grant Human Resources IACUC Intellectual Property Intoxication Investigational Drugs Isoflurophate Laboratories Lead Leadership Legal patent Logistics Manuscripts Medical Research Mission Monitor Online Systems Organophosphates Paraoxon Picrotoxin Policies Procedures Protocols documentation PubMed Readiness Reagent Regulation Reporting Research Research Activity Research Institute Research Personnel Research Project Grants Resource Sharing Role Safety Secure Security Seizures Series Soman Strategic Planning System Technology Transfer Therapeutic Therapeutic Agents TimeLine Training United States Food and Drug Administration United States National Institutes of Health Universities Work authority central database chemical threat data exchange data management data sharing education research improved interest medical countermeasure meetings novel operation prevent programs receptor research and development statistics success synergism tetramethylenedisulfotetramine therapeutic development web site

项目摘要

Project Summary – Administrative Core The overall goal of the UC Davis CounterACT Center of Excellence is to identify and advance improved medical countermeasures for stopping seizures and preventing long-term consequences of acute intoxication with chemical threat agents, specifically organophosphate cholinesterase inhibitors like diisopropylfluorophosphate (DFP), paraoxon and soman, or GABAA receptor blockers like tetramethylenedisulfotetramine (TETS) and picrotoxin. The UC Davis CounterACT Center comprises three projects, three scientific cores, a research education core and multiple committees — all of which must work closely together to ensure success. The role of the Administrative Core is to oversee and coordinate the scientific and administrative operations of the Center's activities and to foster interactions and synergism among Center research projects and scientific cores, ultimately ensuring the Center meets annual milestones established in collaboration with NIH CounterACT program officer(s). Additionally, the Administrative Core will coordinate interactions with the UC Davis administration and external entities, such as the NIH CounterACT administration, the Center's External Advisory Committee, the larger CounterACT research community, the U.S. Food and Drug Administration (FDA), the Biomedical Advanced Research and Development Authority (BARDA), and commercial partners. The Core's objectives are: (1) Develop a strategic plan for achieving annual Center milestones and ensure its effective and efficient implementation; (2) Provide scientific leadership and logistical support to coordinate and integrate Center activities and promote interactions among Center investigators; (3) Facilitate data and resource sharing among Center investigators and other CounterACT investigators; (4) Provide budgetary oversight and grant management; (5) Ensure the safety and security of personnel, materials, data and facilities; (6) Coordinate the development of intellectual property (IP) strategies and the transitioning of leads for advanced development; (7) Coordinate with FDA, BARDA and other federal government agencies; and (8) Identify, engage and coordinate communications with commercial partners.

项目摘要 – 行政核心加州大学戴维斯分校 CounterACT 卓越中心的总体目标是确定并推进改进的医疗停止癫痫发作和预防急性中毒长期后果的对策化学威胁剂，特别是有机磷酸酯胆碱酯酶抑制剂，如二异丙基氟磷酸盐 (DFP)、对氧磷和梭曼，或 GABAA 受体阻滞剂，如四亚甲基二磺四胺 (TETS) 和加州大学戴维斯分校 CounterACT 中心包括三个项目、三个科学核心、一项研究。教育核心和多个委员会——所有这些都必须紧密合作以确保成功。行政核心的职责是监督和协调科学和行政运作中心的活动并促进中心研究项目和科学核心之间的相互作用和协同作用，最终确保该中心达到与 NIH CounterACT 合作建立的年度里程碑此外，行政核心将协调与加州大学戴维斯分校的互动。行政部门和外部实体，例如 NIH CounterACT 行政部门、中心的外部咨询委员会、更大的 CounterACT 研究团体、美国食品和药物管理局 (FDA)、生物医学高级研究与开发局 (BARDA) 以及 The Core 的商业合作伙伴。目标是： (1) 制定实现中心年度里程碑的战略计划，并确保其有效性和（二）科学领导、统筹协调、后勤保障（三）促进数据和资源共享中心调查员和其他 CounterACT 调查员之间； (4) 提供预算监督和拨款（五）确保人员、物资、数据和设施的安全；（七）制定知识产权（IP）战略并转变先进发展的领先地位；与 FDA、BARDA 和其他联邦政府机构协调；以及 (8) 确定、参与和协调与商业伙伴的沟通。