Training Program for Antiretroviral Discovery, Evaluation and Application Research (ADEAR)

抗逆转录病毒发现、评估和应用研究培训计划 (ADEAR)

• 批准号: 10204989
• 负责人: Thomas B. Campbell
• 金额: $ 25.94万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10204989
• 关键词: Anti-Retroviral Agents; Evaluation; Research; Training Programs

PROJECT SUMMARY The Training Program for Antiretroviral Discovery, Evaluation and Application Research (ADEAR) is an integrative program that provides multidisciplinary training in basic, translational and clinical science in human immunodeficiency virus type 1 (HIV)/Acquired Immunodeficiency Syndrome (AIDS) research. Postdoctoral scientist will receive training under the direction of a broadly based group of faculty at the University of Colorado, Colorado State University and the University of Denver who are who experienced mentors and actively engaged in research related to the discovery and evaluation of new antiretroviral drugs or the application of existing antiretrovirals for the treatment and prevention of HIV/AIDS. This application for T32 grant funding will establish ADEAR as a new research training program that will provide interactive postdoctoral research training to produce well-rounded laboratory and clinical scientists who are better able to address the knowledge gaps needed to end the global AIDS epidemic. To foster multidisciplinary research opportunities for ADEAR trainees, the program has engaged experienced and productive HIV/AIDS investigators as mentors for trainees. The areas of mentored training available to trainees include antiretroviral discovery through basic and translational science, clinical evaluation of antiretrovirals, and application of antiretrovirals in clinical and community settings. The proposed program includes the following innovative features:  Thomas Campbell, M.D., an experienced clinical investigator and mentor, and Mamuka Kvaratskhelia, Ph.D., an experienced basic scientist and mentor will serve as Co-Program Directors.  Integrated HIV Clinical Investigator and HIV Basic/Translational Scientist pathways within the program to better meet the training needs of trainees with diverse research backgrounds and career paths.  A robust plan to facilitate recruitment of trainees both from within the affiliated institutions and from other institutions outside of Colorado.  A formal plan to improve the mentoring skills of program faculty.  Measures to facilitate trainee careers as NIH funded independent investigators including a required individual Career Development Plan; clearly defined career development “deliverables” including research publications and requirement of submission of a K award application; and provision of up to 3 years of support to trainees to ensure sufficient time to develop a K application.  Robust methods for internal and external review of program progress and procedures for adjusting the training curriculum, if necessary, to better meet the needs of trainees. The proposed postdoctoral training program will be well equipped to train basic and clinical scientists from diverse disciplines, prepare them for collaborative research careers, and thereby produce investigators with the skills needed to fill knowledge gaps in the use of antiretrovirals as tools to end HIV/AIDS.

项目摘要 抗逆转录病毒发现，评估和应用研究（ADEAR）的培训计划是 在人类基础，翻译和临床科学方面提供多学科培训的综合计划 免疫缺陷病毒1型（HIV）/获得的免疫缺陷综合征（AIDS）研究。博士后 科学家将在大学的一群基于广泛的教职员工的指导下接受培训 科罗拉多州科罗拉多州立大学和丹佛大学，他们是经验丰富的导师和 积极从事与新抗逆转录病毒药物的发现和评估有关的研究 现有的抗逆转录病毒治疗和预防艾滋病毒/艾滋病的应用。 T32赠款资金申请将建立Adear作为新的研究培训计划，将 提供交互式的博士后研究培训，以生产全面的实验室和临床科学家 能够更好地解决结束全球艾滋病流行所需的知识差距。养育 ADEAR学员的多学科研究机会，该计划已参与经验和 生产性艾滋病毒/艾滋病研究人员是培训的导师。可用于指导培训领域 受训者包括通过基本和转化科学发现的抗逆转录病毒发现， 抗逆转录病毒和抗逆转录病毒在临床和社区环境中的应用。拟议的计划 包括以下创新功能： 托马斯·坎贝尔（Thomas Campbell） 博士学位，一位经验丰富的基础科学家和精神将担任副总监。 该计划中的HIV临床研究者和HIV基本/转化科学家途径 更好地满足具有潜水员研究背景和职业道路的受训者的培训需求。 一项强大的计划，以支持会员机构内部的招募受训者的招聘 科罗拉多州以外的其他机构。 一项正式计划，以提高计划教师的心理技能。 作为NIH资助的独立调查员，包括所需的措施 个人职业发展计划；明确定义的职业发展“可交付成果”，包括 研究出版物和提交K奖申请的要求；并提供最多3 多年来对学员的支持，以确保足够的时间开发K应用。 强大的方法，用于内部和外部审查程序进度和程序的程序，以调整 如有必要，培训课程可以更好地满足培训的需求。 拟议的博士后培训计划将有能力培训来自 多样化的学科，为合作研究事业做好准备，从而使研究人员与 在使用抗逆转录病毒作为结束艾滋病毒/艾滋病的工具中，需要填补知识空白所需的技能。