Neural basis of vocal signal recognition during natural communication

自然交流过程中声音信号识别的神经基础

• 批准号: 10201557
• 负责人: CORY T MILLER
• 金额: $ 33.47万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10201557
• 关键词: Acoustics; Address; Adult; Anatomy; Area; Auditory; Auditory area; Auditory system; Behavior; Brain; Callithrix; Characteristics; Chronic; Communication; Computer software; Data; Dependovirus; Disease; Environment; Face; Feedback; Female; Foundations; Functional Magnetic Resonance Imaging; Human; Human Characteristics; Individual; Interneurons; Laboratories; Language; Macaca mulatta; Maps; Measures; Methods; Modeling; Molecular; Neocortex; Neurologic; Neurons; Pathway interactions; Pattern; Play; Population; Preparation; Primates; Process; Property; Pyramidal Cells; Recombinant adeno-associated virus (rAAV); Role; Sex Differences; Signal Transduction; Societies; Speech; Stimulus; Structure; System; Techniques; Testing; Voice; auditory pathway; awake; base; cell type; communication behavior; experimental study; extrastriate visual cortex; frontal lobe; innovation; male; neural circuit; neuroimaging; neuromechanism; neurophysiology; nonhuman primate; novel; optogenetics; promoter; relating to nervous system; response; signal processing; social; sound; tool; virtual; vocalization

Project Summary Communication is an inherently interactive process involving the exchange of information between individuals. For communication to occur, individuals must both recognize the sound as a social signal (e.g. vocalizations), rather than another sound in the environment, as well as the relevant information encoded within the structure of the signal, such as the caller's identity. Despite the relative ease with which the primate auditory system is able to perform these computations, and evidence of vocal signal processing in primate cortex, relatively is known about the neural mechanisms underlying recognition of these communication signals. The primary aim of this proposal is to investigate the complementary roles of auditory and frontal cortex for vocal signal recognition during natural communication. To investigate this process, we employ a multi-technique approach aimed at elucidating the mechanisms underlying vocal signal recognition throughout the ventral auditory cortical system during marmoset antiphonal conversations. Aim 1 utilizes neuroimaging (fMRI) to identify vocalization responsive populations in the auditory and frontal cortex in awake subjects. The primary aim here is to test whether particular areas of these substrates in the cortical auditory system and will serve as a foundation for subsequent experiments in the proposal. Aim 2 builds on these findings to record the neurophysiological characteristics of neurons in auditory and frontal cortex while freely-moving marmosets engage in their naturally occurring antiphonal conversations. We employ a novel interactive playback paradigm in which subjects directly engage in these vocal interactions with a software-generated `Virtual Marmoset' (VM). Because the vocal behavior and signals of the VM can be experimentally manipulated, we will use this paradigm to test the responses of neurons throughout these substrates for call recognition and social recognition. Aim 3 utilizes optogenetic techniques to explicitly test the functional contributions of auditory cortex for vocal signal recognition. We employ a novel, chronic optogenetic preparation developed in my laboratory for marmosets to selectively photostimulate primary auditory cortex and the rostral belt region during antiphonal conversations. Subjects will engage in the same VM paradigms used in Aim 2 during these experiments to test the respective functional contributions of these substrates on call and social recognition during natural communication.

项目摘要 沟通是一个固有的互动过程，涉及个人之间的信息交换。 为了进行沟通，个人必须俩都认识到声音是社交信号（例如发声）， 而不是环境中的另一种声音以及结构中编码的相关信息 信号，例如呼叫者的身份。尽管灵长类听觉系统相对轻松 能够执行这些计算，以及在灵长类皮层中的人声信号处理的证据，相对是 关于这些通信信号的识别的神经机制已知。主要目的 该建议的是调查听觉和额叶皮层的互补作用 自然交流期间的认可。为了调查这一过程，我们采用了多技术方法 旨在阐明整个腹听觉的声音信号识别的机制 果果会在反音对话中的皮质系统。 AIM 1利用神经影像学（fMRI）来识别 在听觉和额叶皮层中的发声响应式种群在清醒主题中。这里的主要目的 是测试皮质听觉系统中这些底物的特定区域，并将作为 该提案中后续实验的基础。 AIM 2基于这些发现，以记录 在听觉和额叶皮质中神经元的神经生理特征，同时自由移动摩尔 进行自然发生的反音对话。我们采用新颖的互动播放 受试者直接与软件生成的`虚拟的范式进行了这些声音互动 Marmoset'（VM）。因为可以通过实验操纵VM的声音行为和信号，所以我们 将使用此范式来测试这些基质中神经元的响应，以识别呼叫识别和 社会认可。 AIM 3利用光遗传技术明确测试听觉的功能贡献 声带识别的皮质。我们在我的 在选择性光刺激的原代听觉皮层和the骨皮带区域的实验室 反音对话。受试者将在AIM 2中使用相同的VM范例 测试这些基板在呼叫和社会认可方面的功能贡献的实验 在自然交流中。