Research Infrastructure Core

研究基础设施核心

基本信息

批准号：
10361230
负责人：
Valerie Odero-Marah
金额：
$ 16.9万
依托单位：
CLARK ATLANTA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-06-01 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10361230
关键词：
Address African American African American population African Caribbean American Animal Experimentation Animals Bioinformatics Biological Factors Biometry Cancer Etiology Caucasians Cellular biology Cessation of life Collaborations Communities Core Facility Death Rate Development Ensure Environmental Risk Factor Equipment Funding Genetic Genomics Histology Image Imaging Device Incidence Laboratories Laboratory Personnel Logistics Malignant Neoplasms Malignant neoplasm of lung Malignant neoplasm of prostate Methodology Minority-Serving Institution Molecular Biology Morehouse School of Medicine NCI Center for Cancer Research Parents Patients Phase Pilot Projects Postdoctoral Fellow Proteomics Research Research Infrastructure Research Personnel Research Project Grants Research Support Resources Scientist Services Signal Transduction Supervision Tissue Banks Training Translational Research Travel Universities animal care animal facility anticancer research indexing instrument instrumentation laboratory facility member men mortality operation programs prostate cancer metastasis racial disparity research and development research facility senior faculty structural biology success therapeutic development tissue resource training project

项目摘要

Research Infrastructure Core Abstract Prostate cancer is the second leading cause of cancer deaths among American men after lung cancer. In African-American men, the incidence of prostate cancer is 65% higher and the mortality rate is more than double compared to Caucasian men. The reasons for this racial disparity in incidence and death rate in African-Americans are poorly understood, but may involve both biological and environmental factors. The Center for Cancer Research and Therapeutic Development (CCRTD) at Clark Atlanta University (CAU) is committed to an on-going approach to enhance the comprehensive research program to investigate the cellular and genetic factors involved in initiation, progression and metastasis of prostate cancer through three research and pilot projects proposed in the current proposal. In order to support the research and pilot projects, the Research Infrastructure Core will support five functional Core Laboratories with state-of-the-art instruments and related services. Moreover, an Animal Core Laboratory will be created to provide project leaders with local quality animal care and advance animal research. Lastly, enhanced training will be provided to ensure that project leaders and other users are acquainted with the application of core equipment. In conclusion, the Research Infrastructure Core will be an invaluable resource to the research and pilot projects, as well as the larger research community, to provide state-of-the-art instrumentation, and ensure the success of the proposed research.

研究基础设施核心抽象的前列腺癌是美国男性癌症死亡的第二大原因，仅次于肺癌。在非裔美国人，前列腺癌的发病率高65％，死亡率高于与高加索男性相比两倍。这种种族差异在发病率和死亡率中的原因非裔美国人的理解很少，但可能涉及生物学和环境因素。这克拉克亚特兰大大学（CAU）的癌症研究与治疗发展中心（CCRTD）是致力于采取一种持续的方法来增强综合研究计划，以调查细胞和遗传因素参与前列腺癌的起始，进展和转移，三个当前建议中提出的研究和试点项目。为了支持研究和试点项目，研究基础设施核心将用最先进的工具支持五个功能性核心实验室和相关服务。此外，将创建一个动物核心实验室，以向项目负责人提供本地优质的动物护理和进步动物研究。最后，将提供增强的培训，以确保项目负责人和其他用户熟悉核心设备的应用。总之，研究基础设施核心将成为研究和试点项目的宝贵资源，以及更大的研究社区，提供最先进的仪器，并确保拟议的成功研究。