Quantitative and Spectroscopic Imaging of Skeletal Muscle Changes in Sarcopenia at High Field

高场肌少症骨骼肌变化的定量和光谱成像

• 批准号: 10360674
• 负责人: Bragi Sveinsson
• 金额: $ 11.45万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10360674
• 关键词: 3-Dimensional; Affect; Age; Awareness; Biological Markers; Clinical; Communities; Consensus; Data; Development; Diffuse; Diffusion; Elderly; Evaluation; Fatty acid glycerol esters; Fiber; Fracture; Frequencies; Future; Gait speed; Geriatrics; Goals; Hand Strength; Health; Health Personnel; Hospitalization; Human; Image; Imaging Techniques; Inflammation; Investigation; Life Expectancy; Lipids; Machine Learning; Magnetic Resonance; Magnetic Resonance Imaging; Measurement; Measures; Medical Imaging; Metabolic; Metabolic Marker; Methods; Morphologic artifacts; Morphology; Muscle; Muscle function; Muscular Atrophy; Noise; Patients; Phase; Physiologic pulse; Predisposition; Prevalence; Protons; Proxy; Relaxation; Research; Resolution; Role; Running; Signal Transduction; Site; Skeletal Muscle; Soleus Muscle; Spatial Distribution; Spectrum Analysis; Structure; Techniques; Testing; Time; Tissues; Treatment Effectiveness; United States; Water; Work; aging population; base; bone imaging; carbene; clinical biomarkers; design; diagnostic criteria; falls; imaging biomarker; imaging modality; improved; in vivo; innovation; muscle form; muscle strength; muscular structure; novel; potential biomarker; quantitative imaging; radio frequency; recruit; sarcopenia; spectroscopic imaging; therapy development

Project Summary Sarcopenia, a condition characterized by loss of muscle mass and function in the elderly, is of increasing relevance in the United States due to its aging population. It is generally agreed that the weakening of the muscle in sarcopenia cannot be explained by loss of muscle mass alone, but the mechanisms behind this remain poorly understood. This is partly due to the lack of non-invasive techniques for observing muscle structure and composition in high detail. We propose to develop MRI techniques to measure muscle morphology, microstructure, and fat content to get a detailed view of the changes in muscle quantity and quality in patients with sarcopenia and how they relate to more easily attainable measurements of muscle function such as grip strength and gait speed. This would provide an important contribution to the ongoing debate about how such measurements could be used to define sarcopenia, which would pave the way for treatment development. We aim to develop novel methods to investigate the structure and composition of muscle using ultra-high-field MRI. Specifically, we aim to (1) obtain water-based images of skeletal muscle macro- and microstructure with unparalleled efficiency, image quality, and resolution; (2) obtain images of the spatial distribution of intramyocellular lipids in skeletal muscle, measuring both methyl and methylene to estimate saturation; and (3) to conduct a study comparing skeletal muscle structure and quality by looking at MR measurements of T2 relaxation rates, diffusivity (as proxies for inflammation and fiber size, respectively), fat fraction, and lipid composition, in subjects with sarcopenia and healthy controls and see how these quantities correlate to muscle function. This project has several innovative aspects. First, we will develop a method to estimate muscle morphology, T2 relaxation rates, and diffusivity with a single MRI sequence. Importantly, this will make the developed method easy to run at other MRI sites. Second, we will devise methods to perform robust, efficient imaging of intramyocellular lipid droplet distribution and saturation in human skeletal muscle in vivo at high field. Both of these methods will have unparalleled signal-to-noise ratio and robustness against image artifacts. The significance of this work is the investigation of the role of inflammation, fiber size, and lipid distribution in the weakening of muscle in sarcopenia and how these measurements are related to muscle function. The resulting conclusions and techniques may help establish a common standard for the definition of sarcopenia and aid in the development of future treatments for this condition.

项目概要 肌肉减少症是一种以老年人肌肉质量和功能丧失为特征的疾病，其发病率正在不断增加 由于美国人口老龄化，其重要性不言而喻。人们普遍认为，肌肉的衰弱 肌肉减少症不能仅用肌肉质量损失来解释，但其背后的机制仍然很差 明白了。这部分是由于缺乏观察肌肉结构和肌肉结构的非侵入性技术。 高度详细的构图。我们建议开发 MRI 技术来测量肌肉形态， 微观结构、脂肪含量，详细了解患者肌肉数量和质量的变化 肌肉减少症及其与更容易实现的肌肉功能测量（例如握力）的关系 力量和步态速度。这将为正在进行的关于如何实现这一目标的辩论做出重要贡献。 测量结果可用于定义肌肉减少症，这将为治疗方法的开发铺平道路。 我们的目标是开发利用超高场研究肌肉结构和组成的新方法 核磁共振成像。具体来说，我们的目标是（1）获得骨骼肌宏观和微观结构的水基图像 无与伦比的效率、图像质量和分辨率； (2) 获取空间分布图像 骨骼肌中的肌细胞内脂质，测量甲基和亚甲基以估计饱和度；和（3） 通过观察 T2 的 MR 测量值来进行比较骨骼肌结构和质量的研究 弛豫率、扩散率（分别作为炎症和纤维尺寸的代表）、脂肪分数和脂质 肌肉减少症受试者和健康对照者的成分，看看这些数量与肌肉的关系 功能。 该项目有几个创新的方面。首先，我们将开发一种估计肌肉形态 T2 的方法 单个 MRI 序列的弛豫率和扩散率。重要的是，这将使开发的方法 易于在其他 MRI 站点运行。其次，我们将设计方法来执行稳健、高效的成像 高场下人体骨骼肌体内肌细胞内脂滴的分布和饱和度。两者都 这些方法将具有无与伦比的信噪比和对图像伪影的鲁棒性。这 这项工作的意义在于研究炎症、纤维大小和脂质分布在 少肌症患者的肌肉减弱以及这些测量结果与肌肉功能的关系。由此产生的 结论和技术可能有助于建立肌肉减少症定义的共同标准并帮助 针对这种情况的未来治疗方法的开发。

项目成果

Synthesizing Quantitative T2 Maps in Right Lateral Knee Femoral Condyles from Multicontrast Anatomic Data with a Conditional Generative Adversarial Network.

• DOI: 10.1148/ryai.2021200122
• 发表时间: 2021-05
• 期刊: Radiology. Artificial intelligence
• 作者: B. Sveinsson;A. Chaudhari;Bo Zhu;Neha Koonjoo;M. Torriani;G. Gold;M. Rosen