Thalamocortical interactions

丘脑皮质相互作用

基本信息

批准号：
10361725
负责人：
Jason Neil MacLean
金额：
$ 58.48万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-01 至 2027-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10361725
关键词：
Abbreviations Acetylcholine Address Affect Alzheimer&apos s Disease Anatomy Area Back Behavioral Binding Biological Models Brain Cell Nucleus Cells Cognitive deficits Control Animal Data Detection Discrimination Dorsal Electrodes Electrophysiology (science)Excitatory Postsynaptic Potentials Explosion Feedback Fluorescence Future Generations Geniculate body structure Glutamates Image In Vitro Label Lateral Geniculate Body Maps Medial Metabotropic Glutamate Receptors Modeling Monitor Motor Cortex Mus Nerve Neurons Pathway Analysis Pathway interactions Pattern Peripheral Phase Physiology Play Preparation Progress Reports Property Pulvinar structure Research Role Route Schizophrenia Sensory Short-Term Memory Slice Source Spinal Stimulus Synapses System Tactile Techniques Testing Thalamic Nuclei Thalamic structure Virus barrel cortex behavior test cognitive function density experimental study gamma-Aminobutyric Acid in vivo interest neglect postsynaptic programs response sensory cortex sensory input somatosensory two-photon

Abbreviations Acetylcholine Address Affect Alzheimer&apos s Disease Anatomy Area Back Behavioral Binding Biological Models Brain Cell Nucleus Cells Cognitive deficits Control Animal Data Detection Discrimination Dorsal Electrodes Electrophysiology (science)Excitatory Postsynaptic Potentials Explosion Feedback Fluorescence Future Generations Geniculate body structure Glutamates Image In Vitro Label Lateral Geniculate Body Maps Medial Metabotropic Glutamate Receptors Modeling Monitor Motor Cortex Mus Nerve Neurons Pathway Analysis Pathway interactions Pattern Peripheral Phase Physiology Play Preparation Progress Reports Property Pulvinar structure Research Role Route Schizophrenia Sensory Short-Term Memory Slice Source Spinal Stimulus Synapses System Tactile Techniques Testing Thalamic Nuclei Thalamic structure Virus barrel cortex behavior test cognitive function density experimental study gamma-Aminobutyric Acid in vivo interest neglect postsynaptic programs response sensory cortex sensory input somatosensory two-photon

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项目摘要

The proposed research will test related hypotheses that thalamus plays a heretofore neglected and critical role in cortical processing. In particular, many thalamic nuclei, that together comprise the majority of thalamic volume and that were previously mysterious in function, we now suggest are critically involved in information flow and functional, dynamic binding between cortical areas via cortico-thalamo-cortical pathways. We propose to study these pathways using the mouse somatosensory system as the model involving both in vitro slice preparations and an in vivo behaving preparation. It appears that, in many and perhaps all cases, cortical areas are connected by both direct and these transthalamic pathways. The transthalamic pathways are only recently appreciated, and we aim to explore some basic roles such pathways play in cortical processing. To begin understanding the role of such pathways, we propose to probe basic circuit properties of these pathways to better understand the role of the transthalamic pathways in higher cognitive functioning.

拟议的研究将检验与丘脑扮演的迄今忽视的相关假设，并且在皮质加工中的关键作用。特别是，许多丘脑核共同包含我们现在建议的是丘脑量的大部分，而且以前在功能上都是神秘的通过皮质 - 丘脑皮层途径。我们建议使用鼠标研究这些途径体感系统作为涉及体外切片制剂和体内的模型行为准备。看来，在许多情况下，也许所有情况下，皮质区域都连接通过直接和这些经过脑丘脑的途径。脑丘脑途径直到最近才值得赞赏的是，我们旨在探索这种途径在皮质加工中发挥的基本作用。到开始理解这种途径的作用，我们建议探测的基本电路特性这些途径更好地了解脑丘脑途径在较高认知中的作用功能。