Project 2- Attention and Dual Task Interference

项目2-注意力和双重任务干扰

基本信息

批准号：
8705586
负责人：
KEITH H NUECHTERLEIN
金额：
$ 16.39万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-19 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8705586
关键词：
Accounting Activities of Daily Living Acute Address Attention Attentional deficit Behavioral Sciences Cereals Chronic Phase Chronic Schizophrenia Clinical Clinical Research Cognition Cognitive Cognitive Science Cognitive deficits Collaborations Communities Consensus Data Decision Making Dimensions Emotions Episodic memory Functional disorder Gambling Grant Independent Living Individual Instruction Intermediate Variables Iowa Lead Learning Life Literature Measures Mediator of activation protein Memory Memory impairment Modeling Motivation Motor National Institute of Mental Health Nature Neurocognition Neurocognitive Outcome Parietal Pathway interactions Patient Selection Patients Performance Phase Play Process Production Psychological Refractory Period Punishment Relative (related person)Research Research Personnel Resources Response to stimulus physiology Rewards Role Schizophrenia Severities Site Social Functioning Social Work Stimulus Structural Models Testing Time Translational Research Variant Work base cognitive neuroscience first episode schizophrenia functional outcomes hedonic improved indexing interest memory process memory retrieval operation programs prospective relating to nervous system response social social cognition white matter

项目摘要

PROJECT SUMMARY (See instructions); PROJECT 2: ATTENTION AND DUAL-TASK INTERFERENCE We continue to use a translational behavioral science strategy to bring paradigms with greater analytic power to the study of attention in schizophrenia. The collaboration between Dr. Pashler of UCSD and clinical researchers Drs. Nuechterlein and Subotnik of UCLA has yielded strong evidence in favor of specific models of structural processing bottlenecks in divided attention in schizophrenia. Beyond this, sites of marked structural processing bottlenecks in schizophrenia have been isolated in response selection processes and response production processes. Thus, while perceptual encoding proceeds normally without causing dual-task interference in schizophrenia patients, response selection processes and response production (motoric) processes in one task markedly interfere with doing another task. While many aspects of dual-task interference are abnormal across phases of illness, some component of an abnormally severe processing bottleneck tend to progress in severity from prodromal to later phases of schizophrenia. Motoric interference also predicts later work functioning independently from memory and social cognition deficits, suggesting that it has a distinctive role. In the next phase ofthis project, several new steps are proposed. First, to integrate findings in the memory project with the findings ofthis attention project, we will examine whether declarative memory processes interfere with other simultaneous processing in a way that involves a particularly severe structural processing bottleneck in schizophrenia. Second, we will extend the findings ofthis project to situations that involve motivated decisions with hedonic consequences, rather than only simple pre-designated response selections. Third, we will examine further whether the contribution of motor processes to attentional dysfunction and functional outcome is distinct from the contribution of memory processes. Finally, we will examine the extent to which indicators of particular processing bottlenecks in schizophrenia serve as contributors to functional capacity and through it contribute to everyday functional level.

项目摘要（参见说明）；项目 2：注意力和双任务干扰我们继续使用转化行为科学策略将具有更强分析能力的范式引入精神分裂症的注意力研究中。这加州大学圣地亚哥分校的 Pashler 博士与临床研究人员 Drs. 的合作。加州大学洛杉矶分校的 Nuechterlein 和 Subotnik 提供了强有力的证据支持分散注意力中结构处理瓶颈的特定模型精神分裂症。除此之外，精神分裂症中明显的结构处理瓶颈位点已被证实。在响应选择过程和响应生成过程中被隔离。因此，虽然感知编码正常进行，不会对精神分裂症患者造成双重任务干扰，反应选择一项任务中的过程和反应产生（运动）过程明显干扰另一项任务的完成。虽然双重任务干扰的许多方面在疾病的各个阶段都是异常的，但异常严重的处理瓶颈往往会从前驱阶段发展到后期阶段精神分裂症。运动干扰还预示着以后的工作将独立于记忆和社交认知缺陷，表明它具有独特的作用。在该项目的下一阶段，将采取几个新步骤建议的。首先，为了将记忆项目的发现与注意力项目的发现结合起来，我们将检查声明性记忆过程是否以某种方式干扰其他同时处理涉及精神分裂症中特别严重的结构处理瓶颈。其次，我们将延长该项目的发现涉及涉及享乐后果的动机决策的情况，而不是仅简单的预先指定的响应选择。第三，我们将进一步考察是否有贡献。运动过程对注意力功能障碍和功能结果的影响与记忆的贡献不同流程。最后，我们将检查特定处理瓶颈指标的程度精神分裂症是功能能力的贡献者，并通过它促进日常功能水平。