Enhanced Biomechanical Modeling of the Breast for Womens Health

增强乳房生物力学模型以促进女性健康

• 批准号: 10356348
• 负责人: Kristy Brock
• 金额: $ 65.1万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-10 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10356348
• 关键词: 3-Dimensional; Adipose tissue; Anatomy; Anisotropy; Back; Behavior; Biomechanics; Breast; Characteristics; Chest wall structure; Clothing; Data; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Engineering; Goals; Grant; Human; Individual; Knowledge; Literature; Location; Malignant Neoplasms; Mammaplasty; Mammary Gland Parenchyma; Mastectomy; Medical; Modeling; Motion; Movement; Operative Surgical Procedures; Outcome; Outcome Measure; Pathologist; Patient Education; Patients; Performance; Physicians; Physics; Physiological; Population; Property; Quality of life; Recovery; Research; Structure; Support System; Surgeon; System; Testing; Three-dimensional analysis; Tissue Model; Tissues; Training and Education; Translations; Uncertainty; Vision; Women' s Health; Work; base; biomechanical model; clinical translation; design; improved; innovation; malignant breast neoplasm; multidisciplinary; multimodality; prevent; primary outcome; shared decision making; simulation; three-dimensional modeling; tool; tumor

As biomechanical modeling of the breast is integral to predicting tumor location across multimodal diagnostic imaging and during surgery, surgical planning, generating simulations for physician and patient education, and brassiere and clothing design for optimal breast support, advances in model accuracy have the potential to significantly improve women's health and quality of life. Despite the growing use of breast biomechanical models for different applications, there are persistent knowledge gaps in both the anatomical and biomechanical literature that prevent an accurate model from being developed and deployed to patient-specific applications. Accurate biomechanical models are needed for tracking cancer in diagnostic imaging and surgery. However, the accuracy of biomechanical models is sensitive to the geometrical and structural features used to describe the anatomical features and the constitutive parameters used to describe the behavior of the tissues. For example, small alterations in the stiffness of the various breast tissue properties can displace tissues by more than 10 mm. Thus, thorough characterization of the constitutive properties of individual breast structures are necessary to obtain precise predictions of tissue motion. Furthermore, in the absence of precise knowledge of anatomical geometrical and structural features, biomechanical models have placed an overemphasis on the constitutive parameters of the breast tissue. The long-term goal of our research is to develop an accurate biomechanical model of the breast that transforms the applications of breast modeling for both population models and patient-specific applications. Our vision is to improve the model so that it becomes a reliable and useful tool in the diagnosis and management of breast cancer, surgeon education and training, patient education for better shared decision making, and clothing design, especially in the post mastectomy recovery period. Our present human breast tissue biomechanical model represents the state of the art, as it is based on actual 3D analyses. However, it represents a first step, as clinical translation remains limited by insufficient information about the structural and biomechanical characteristics of the fascial support system and its relationship to the adipose and glandular breast structures in the broader population. Thus, we hypothesize that the accuracy of the biomechanical model may be improved by determining the anatomical and biomechanical characteristics of the fascial support system of the breast, understanding the sensitivity of the patient-specific parameters across the population, and validating the translation of these models, with their inherent uncertainties, into the patient-specific setting. Our multi-disciplinary team of breast reconstructive surgeons, engineers, medical physicists, and pathologists are uniquely poised to perform this innovative research leading to the development of a high-fidelity biomechanical model of the human breast that is capable of reproducing its behavior, both in general and in a patient specific sense.

由于乳房的生物力学建模是预测跨多模式的肿瘤位置不可或缺的 诊断成像以及手术，手术计划，为医师和患者生成模拟 教育，胸罩和服装设计，可用于最佳乳房支持，模型准确性的进步具有 显着改善妇女的健康和生活质量的潜力。尽管乳房的使用越来越多 用于不同应用的生物力学模型，解剖学和 生物力学文献防止精确模型被开发和部署到患者特定 申请。在诊断成像和手术中追踪癌症需要准确的生物力学模型。 但是，生物力学模型的准确性对用于的几何和结构特征敏感 描述用于描述组织行为的解剖学特征和本构参数。 例如，各种乳腺组织特性的刚度的较小改变可以通过 超过10毫米。因此，彻底表征单个乳房结构的本构特性 对于获得组织运动的精确预测是必要的。此外，在没有精确知识的情况下 关于解剖学几何和结构特征，生物力学模型已过分强调 乳腺组织的组成型参数。 我们研究的长期目标是开发乳房的准确生物力学模型 改变乳房建模在人群模型和患者特定应用中的应用。我们的 愿景是改善模型，以便成为诊断和管理的可靠且有用的工具 乳腺癌，外科医生教育和培训，患者教育以更好地共享决策和服装 设计，尤其是在乳房切除术后恢复期间。 我们目前的人类乳腺组织生物力学模型代表了艺术的状态，因为它是基于 实际的3D分析。但是，这代表了第一步，因为临床翻译仍然受到不足的限制 有关筋膜支撑系统及其结构和生物力学特征及其的信息 与更广泛的人群中的脂肪和腺乳腺结构的关系。因此，我们假设 通过确定解剖学和生物力学，可以提高生物力学模型的准确性 乳房筋膜支撑系统的特征，了解患者特异性的敏感性 人群之间的参数，并验证这些模型的翻译及其固有的 不确定性，进入特定于患者的环境。我们的乳房重建外科医生的多学科团队， 工程师，医学物理学家和病理学家唯一准备进行这项创新的研究领先 为了发展人类乳房的高保真生物力学模型，该模型能够繁殖其 一般而言，行为在特定意义上。