Making connections among social ties, neural sensitivity to social signals, and outcomes

在社会关系、对社会信号的神经敏感性和结果之间建立联系

• 批准号: 10200497
• 负责人: PEARL H CHIU
• 金额: $ 64.71万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10200497
• 关键词: Address; Alcohol consumption; Alcoholism; Alcohols; Anxiety; Behavioral; Brain; COVID-19; Characteristics; Computer Models; Consumption; Enrollment; Equation; Human; Individual; Life; Link; Longitudinal cohort; Measures; Mechanics; Mediating; Mediation; Mental Depression; Mental Health; Modeling; Moods; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Outcome; Participant; Persons; Play; Procedures; Process; Reporting; Request for Applications; Role; Sampling; Signal Transduction; Social Distance; Social Environment; Social Functioning; Social Interaction; Social isolation; Social outcome; Source; Statistical Models; Structure; Testing; Time; To specify; Trust; Visit; Work; addiction; base; behavioral economics; behavioral response; biopsychosocial; design; experience; indexing; interest; neurobiological mechanism; neuroimaging; physical conditioning; preference; recruit; relating to nervous system; response; satisfaction; social; social factors; social structure; tool

PROJECT SUMMARY Social isolation is associated with excessive alcohol use, depression, anxiety, and other poor outcomes (e.g., Daeppen et al., 2013; Moos et al., 2001; Muller et al., 2017; Zuckermann et al., 2020). Substantial variability also exists in these associations, such that individuals with limited social ties do experience positive outcomes and socially connected individuals similarly do experience negative outcomes (Bond et al., 2007; Bryan et al., 2017; Eddie & Kelly, 2017; Spohr et al., 2019). Despite the importance of social factors in alcohol use and related outcomes, the mechanisms via which social connectedness or isolation yield positive and negative outcomes remains largely unexplored, in part due to difficulties eliciting and quantifying interpersonal processes in a parametric manner. We have previously shown that sensitivity to social signals may be parameterized in the context of interactive behavioral economic games and provide powerful tools with which to examine sources of variability and potential mechanisms through which social preferences are related to mental health (Chung et al., 2015; Chiu et al., 2008; King-Casas et al., 2005, 2008; King-Casas & Chiu, 2012). Here, we use these tools to test the possibility that sensitivity to social signals in the context of social interaction influences how social ties yield variability in alcohol use, mood, and anxiety. To examine associations among social connectedness, sensitivity to social signals, and outcomes, we combine a longitudinal cohort design including time-lagged mediation analyses, functional neuroimaging, and a behavioral economic social exchange task. We will assess these associations (i) contemporaneously in Aim 1, (ii) over time in Aim 2, and (iii) following social restrictions related to COVID-19 in a large online sample in Aim 3. The broad hypothesis is that sensitivity to social signals (as measured by neurocomputational indices) will both moderate and mediate associations between social ties and alcohol use and related outcomes. The work is submitted in response to PAR-19-373 requesting applications addressing basic mechanisms of social connectedness, connection, and isolation, including those related to COVID-19. The application further is in line with specific interests of NIAAA and NIMH and in “mechanistic studies of the biopsychosocial causes and effects of social connection and isolation” and “behavioral [and] neurobiological mechanisms of social connection and isolation leading to alcohol use, addiction, or cessation of consumption.”

项目摘要 社会隔离与过量的酒精使用，抑郁症，焦虑和其他不良结果有关（例如， Daeppen等人，2013年； Moos等，2001； Muller等人，2017年； Zuckermann等，2020）。也很大的可变性 存在这些协会，使社会联系有限的个人确实会经历积极的成果，并且 社会联系的个体同样会经历负面结果（Bond等，2007； Bryan等，2017； Eddie＆Kelly，2017年； Spohr等人，2019年）。尽管社会因素在饮酒和相关性中很重要 结果，社会联系或隔离产生积极和负面结果的机制 在很大程度上是出乎意料的，部分原因是难以引起和量化人际关系 参数方式。我们以前已经表明，对社会信号的敏感性可能在参数 交互式行为经济游戏的背景，并提供强大的工具，可利用这些工具来检查 社会偏好与心理健康相关的可变性和潜在机制（Chung ET Al。，2015年； Chiu等，2008； King-Casas等，2005，2008; King-Casas＆Chiu，2012年）。在这里，我们使用这些工具 测试在社会互动背景下对社会信号的敏感性影响社会关系的可能性 在酒精使用，情绪和动画中产生可变性。 要研究社会联系，对社会信号的敏感性和结果之间的关联，我们结合了 纵向队列设计，包括时间滞后的中介分析，功能性神经影像和行为 经济社会交换任务。我们将评估这些关联（i）AIM 1，（ii）随着时间的流逝 在AIM 2和（iii）在AIM 3中的大型在线样本中与Covid-19相关的社会限制。 假设是对社会信号的敏感性（通过神经计算指标衡量）都将中等 并调解社会关系与酒精使用与相关结果之间的关联。工作提交 对第19-373款的响应，要求申请解决社会联系的基本机制， 连接和隔离，包括与COVID-19有关的连接和隔离。该应用程序进一步符合特定的 NIAAA和NIMH的兴趣以及“社会生物心理社会原因和影响的机械研究 联系和隔离”和“社会联系和孤立的行为[和]神经生物学机制 导致饮酒，成瘾或停止消费。”