Transport and bioavailability of U and co-occurring metals in nanoparticulate matter on tribal lands affected by mining legacy

受采矿遗留影响的部落土地上纳米颗粒物质中铀和共生金属的传输和生物利用度

• 批准号: 10353203
• 负责人: Adrian J Brearley
• 金额: $ 28.16万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10353203
• 关键词: Address; Adsorption; Affect; Agricultural Crops; Agriculture; Air; Airborne Particulate Matter; Arizona; Arsenic; Assimilations; Biological Availability; Characteristics; Chemicals; Communities; Copper; Data; Data Set; Deposition; Dust; Electron Microscopy; Electron Probe Microanalysis; Environmental Engineering technology; Environmental Pollution; Environmental Science; Environmental Wind; Exposure to; Goals; Grain; Health; Human; Hydrophobic Interactions; Image; Ingestion; Inhalation; Inhalation Exposure; Investigation; Measurement; Metal exposure; Metals; Meteorology; Microscopy; Minerals; Mining; Modeling; Monitor; Morphology; Native Americans; Navajo; New Mexico; Particle Size; Particulate; Particulate Matter; Pathway interactions; Plant Leaves; Plant Roots; Plants; Poaceae; Process; Property; Public Health; Pueblo Race; Research; Resolution; Risk; Risk Assessment; Risk Estimate; Risk Reduction; Sampling; Signal Recognition Particle; Site; Soil; Solid; Solubility; Source; Southwestern United States; Spectrum Analysis; Squash; Stomas; Structure; Superfund; System; Techniques; Testing; Toxic effect; Ultrafine; Uncertainty; Uranium; Vanadium; Vulnerable Populations; Waxes; agricultural activity; atmospheric modeling; base; community living; experience; experimental study; exposed human population; exposure pathway; field study; fine particles; hazard; indigenous community; innovation; interest; member; metal poisoning; nanoparticle; nanoparticulate; novel strategies; performance site; programs; rapid detection; receptor; remediation; submicron; tool; toxic metal; tribal community; tribal lands; uptake; vulnerable community; wasting

PROJECT 2 - ENVIRONMENTAL PROJECT 2 – ESE Particulate (ESE PM) - PROJECT SUMMARY Abandoned uranium mines (AUM) situated on the tribal lands of the Navajo Nation and Laguna pueblo represent a major source of environmental contamination that threatens public health as a result of mobilization of toxic metals mixtures bearing uranium (U), vanadium (V), copper (Cu), arsenic (As). The transport of toxic metals mixtures into the air in nanoparticulate form, and the subsequent potential for inhalational and ingestion exposures, has never been investigated in a rigorous manner. The proposed research will investigate the potential exposure hazards to toxic metals mixtures in nanoparticulates resulting from inhalation and ingestion via contaminated agricultural crops from AUM sites located on Navajo Nation and Laguna Pueblo tribal lands in Arizona and New Mexico. The project will address the two specific aims: 1) Understanding the physicochemical characteristics and distribution of metals mixtures in a range of environmental samples, including mine wastes, soils (agricultural and background) and airborne particulates around AUM and modelling their transport and deposition by wind into neighboring communities; 2) Assessing the uptake of metals into plants on agricultural soils adjacent to abandoned mine sites to understand if airborne metals-bearing particulates present a potential exposure risk. and 3) understanding the mechanisms of particulate assimilation into agricultural crops through their root and folial system through experimental stDeveloping a process model for the resuspension and transport of metal-bearing PM from AUM sites to estimate exposure risks for nearby vulnerable communities. For the process model, we will a) ascertain the particle size distributions and mineralogic characteristics of metal-bearing PM originating from AUM sites and the exposure potential to vulnerable populations living in the regional airshed under varied meteorological conditions; and b) conduct source-receptor modeling for the region, integrating information from three performance sites and deriving long-term estimates for Navajo community members. The proposed research will utilize state-of-the-art monitoring, chemical, imaging and atmospheric modeling techniques to provide a comprehensive dataset on the concentrations, speciation, valence, solubility, etc., of ultrafine-grained PM nanoparticle scale that are essential to evaluate the potential toxicity and inhalation exposure risk for PM. The results will reduce uncertainty regarding the metal content, exposure concentrations, and sources of AUM- related PM exposures in risk reduction strategies.

项目2-环境项目2- ESE颗粒物（ESE PM） - 项目摘要 位于纳瓦霍国家和拉古纳·普韦布洛的部落土地上的废弃铀矿（AUM） 代表了由于威胁公共卫生的主要环境污染根源 有毒金属的动员混合含铀（U），钒（V），铜（CU），砷（AS）的混合物。 将有毒金属混合物以纳米含量形式运输到空气中，随后的潜力 吸入和摄入的暴露从未以严格的方式进行调查。提议 研究将调查纳米关节中有毒金属混合物的潜在暴露危害，从而 从吸入和摄入，通过纳瓦霍国家的AUM遗址污染的农作物摄入和摄入 拉古纳·普韦布洛（Laguna Pueblo）部落在亚利桑那州和新墨西哥州土地。该项目将解决两个具体目标： 1）了解金属的物理特性和分布在一系列范围内 环境样本，包括矿井，土壤（农业和背景）以及空降零件 在AUM周围，通过风向邻近社区进行建模； 2）评估 将金属吸收到与废弃矿场相邻的农业土壤上的植物中，以了解空中 含金属的成分具有潜在的暴露风险。 3）了解 通过其根和外国系统通过实验性颗粒化合物化合作农作物 为重新悬浮和运输金属含有PM从AUM站点重悬和运输的过程模型 估计附近脆弱社区的风险。对于过程模型，我们将a）确定 来自AUM位点的粒度分布和含金属PM的矿物质学特性， 居住在各种气象下的区域大型居住的脆弱人群的暴露潜力 状况; b）为该地区进行源受体建模，整合了三个地区的信息 绩效站点并得出纳瓦霍社区成员的长期估计。拟议的研究 将利用最先进的监测，化学，成像和大气建模技术来提供 超铁粒颗粒PM的浓度，规格，价，溶解度等的全面数据集 纳米颗粒量表对于评估PM的潜在毒性和吸入风险至关重要。 结果将减少有关金属含量，暴露浓度和AUM-的不确定性 相关的PM暴露在降低风险策略中。