Transport and bioavailability of U and co-occurring metals in nanoparticulate matter on tribal lands affected by mining legacy

受采矿遗留影响的部落土地上纳米颗粒物质中铀和共生金属的传输和生物利用度

• 批准号: 10353203
• 负责人: Adrian J Brearley
• 金额: $ 28.16万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10353203
• 关键词: Address; Adsorption; Affect; Agricultural Crops; Agriculture; Air; Airborne Particulate Matter; Arizona; Arsenic; Assimilations; Biological Availability; Characteristics; Chemicals; Communities; Copper; Data; Data Set; Deposition; Dust; Electron Microscopy; Electron Probe Microanalysis; Environmental Engineering technology; Environmental Pollution; Environmental Science; Environmental Wind; Exposure to; Goals; Grain; Health; Human; Hydrophobic Interactions; Image; Ingestion; Inhalation; Inhalation Exposure; Investigation; Measurement; Metal exposure; Metals; Meteorology; Microscopy; Minerals; Mining; Modeling; Monitor; Morphology; Native Americans; Navajo; New Mexico; Particle Size; Particulate; Particulate Matter; Pathway interactions; Plant Leaves; Plant Roots; Plants; Poaceae; Process; Property; Public Health; Pueblo Race; Research; Resolution; Risk; Risk Assessment; Risk Estimate; Risk Reduction; Sampling; Signal Recognition Particle; Site; Soil; Solid; Solubility; Source; Southwestern United States; Spectrum Analysis; Squash; Stomas; Structure; Superfund; System; Techniques; Testing; Toxic effect; Ultrafine; Uncertainty; Uranium; Vanadium; Vulnerable Populations; Waxes; agricultural activity; atmospheric modeling; base; community living; experience; experimental study; exposed human population; exposure pathway; field study; fine particles; hazard; indigenous community; innovation; interest; member; metal poisoning; nanoparticle; nanoparticulate; novel strategies; performance site; programs; rapid detection; receptor; remediation; submicron; tool; toxic metal; tribal community; tribal lands; uptake; vulnerable community; wasting

PROJECT 2 - ENVIRONMENTAL PROJECT 2 – ESE Particulate (ESE PM) - PROJECT SUMMARY Abandoned uranium mines (AUM) situated on the tribal lands of the Navajo Nation and Laguna pueblo represent a major source of environmental contamination that threatens public health as a result of mobilization of toxic metals mixtures bearing uranium (U), vanadium (V), copper (Cu), arsenic (As). The transport of toxic metals mixtures into the air in nanoparticulate form, and the subsequent potential for inhalational and ingestion exposures, has never been investigated in a rigorous manner. The proposed research will investigate the potential exposure hazards to toxic metals mixtures in nanoparticulates resulting from inhalation and ingestion via contaminated agricultural crops from AUM sites located on Navajo Nation and Laguna Pueblo tribal lands in Arizona and New Mexico. The project will address the two specific aims: 1) Understanding the physicochemical characteristics and distribution of metals mixtures in a range of environmental samples, including mine wastes, soils (agricultural and background) and airborne particulates around AUM and modelling their transport and deposition by wind into neighboring communities; 2) Assessing the uptake of metals into plants on agricultural soils adjacent to abandoned mine sites to understand if airborne metals-bearing particulates present a potential exposure risk. and 3) understanding the mechanisms of particulate assimilation into agricultural crops through their root and folial system through experimental stDeveloping a process model for the resuspension and transport of metal-bearing PM from AUM sites to estimate exposure risks for nearby vulnerable communities. For the process model, we will a) ascertain the particle size distributions and mineralogic characteristics of metal-bearing PM originating from AUM sites and the exposure potential to vulnerable populations living in the regional airshed under varied meteorological conditions; and b) conduct source-receptor modeling for the region, integrating information from three performance sites and deriving long-term estimates for Navajo community members. The proposed research will utilize state-of-the-art monitoring, chemical, imaging and atmospheric modeling techniques to provide a comprehensive dataset on the concentrations, speciation, valence, solubility, etc., of ultrafine-grained PM nanoparticle scale that are essential to evaluate the potential toxicity and inhalation exposure risk for PM. The results will reduce uncertainty regarding the metal content, exposure concentrations, and sources of AUM- related PM exposures in risk reduction strategies.

项目 2 - 环境项目 2 - ESE 颗粒 (ESE PM) - 项目摘要 位于纳瓦霍族和拉古纳普韦布洛部落土地上的废弃铀矿 (AUM) 环境污染的一个主要来源是威胁公众健康，因为 含有铀 (U)、钒 (V)、铜 (Cu)、砷 (As) 的有毒金属混合物的流动。 有毒金属混合物以纳米颗粒形式输送到空气中，以及随后的潜在危害 吸入和摄入暴露从未经过严格的调查。 研究将调查纳米颗粒中有毒金属混合物的潜在暴露危害 通过纳瓦霍保留地 AUM 站点受污染的农作物吸入和摄入，以及 位于亚利桑那州和新墨西哥州的拉古纳普韦布洛部落土地该项目将实现两个具体目标： 1) 了解一系列金属混合物的物理化学特性和分布 环境样本，包括矿山废物、土壤（农业和背景）和空气中的颗粒物 围绕 AUM 并对其通过风向邻近社区的运输和沉积进行建模 2) 评估 废弃矿场附近农业土壤上的植物吸收金属，以了解金属是否通过空气传播 含金属颗粒存在潜在的暴露风险，并且 3) 了解其机制。 通过实验通过根和叶系统将颗粒同化到农作物中 st开发一种工艺模型，用于将含金属颗粒物从 AUM 站点重新悬浮并运输到 估计附近脆弱社区的暴露风险。对于过程模型，我们将 a) 确定 源自 AUM 站点的含金属 PM 的粒度分布和矿物学特征 不同气象条件下区域气域内脆弱人口的暴露潜力 条件；和 b) 对该区域进行源-受体建模，整合来自三个方面的信息 表演场地并得出纳瓦霍社区成员的长期估计。 将利用最先进的监测、化学、成像和大气建模技术来提供 关于超细颗粒 PM 的浓度、形态、化合价、溶解度等的综合数据集 纳米颗粒尺度对于评估 PM 的潜在毒性和吸入暴露风险至关重要。 结果将减少有关金属含量、暴露浓度和 AUM 来源的不确定性 风险降低策略中的相关颗粒物暴露。