High Fidelity Diffusion MRI for Children with Cerebral Palsy in Stem Cell Therapy

干细胞治疗中脑瘫儿童的高保真扩散 MRI

基本信息

  • 批准号:
    10187662
  • 负责人:
  • 金额:
    $ 35.22万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-02-15 至 2023-06-30
  • 项目状态:
    已结题

项目摘要

Abstract: Cerebral palsy (CP) is the most prevalent motor disorder of childhood with complications in other cognitive impairments, affecting 3 out of every 1,000 children. Largely due to in utero or perinatal injuries to the developing brain, CP results in white matter pathology including impairments to the motor pathway. Diffusion MRI (e.g. diffusion tensor imaging, or DTI) can help characterize these white matter impairments, as well as any potential connectivity improvement during treatment. Over the past five years, we have applied high-fidelity diffusion MRI in pediatric CP patients during autologous umbilical cord blood (UCB) stem cell therapies, and developed an understanding of the impact and benefit autologous UCB stem cells have on improving functional outcome and brain connectivity in pediatric CP patients. Specifically, we have found strong evidences in relevant brain networks that: 1) brain connectivity impairments account for the motor and cognitive abnormalities in children with CP at the pre-treatment baseline, 2) brain connectivity increases have a direct impact on functional and behavioral improvements during UCB stem cell therapy, 3) brain connectivity increases beyond that of typical development trajectory have a direct correlation with stem cell dosage above a potential threshold of 1.98 x 107 cells/kg, and 4) the severity of baseline connectivity abnormalities predicts the risk of further decline and the benefit of cell therapy. It was also found that the brain connectivity increase may be associated with improved myelination during cell therapy, through additional preliminary investigations using quantitative susceptibility mapping (QSM). Advancing from this solid foundation, we propose this renewal application to further develop ultrahigh resolution diffusion MRI and connectivity imaging methodologies to study the positive effect of allogenic stem cells derived from UCB (stored at the North Carolina Cord Blood Bank), which can both reach the necessary high dosage (as opposed to the limited autologous UCB stem cells) and be applied to more CP patients (rather than just the ones with UCB saved at birth). Specifically, we propose to: 1) achieve unprecedented magnetic field homogeneity based on our recent innovation on simultaneous RF reception and Bo shimming technology to enable the highest possible spatial resolution and fidelity, 2) achieve multi-band multi-shot 3D diffusion MRI acquisition with ultrahigh submillimeter spatial resolution, optimized SNR and high throughput, and 3) acquire and analyze ultrahigh resolution diffusion MRI and brain connectome maps, as well as DTI-guided myelin-sensitive QSM along white matter pathways and throughout the brain connectome, in pediatric CP patients during the course of innovative therapies using UCB-derived allogenic stem cells. It is expected that our continued and concerted efforts will greatly advance our understanding of the neural mechanisms on both connectivity impairments in children with CP at the baseline and on the impact of stem cell therapy on connectivity restorations, ultimately providing compelling evidence to help plan the best treatment options.
抽象的: 脑瘫(CP)是最普遍的儿童疾病,在其他认知中并发症 障碍,每1000名儿童中有3个。很大程度上是由于子宫或围产期伤害 开发大脑,CP会导致白质病理学,包括对电动途径的损害。 扩散MRI(例如扩散张量成像或DTI)可以帮助表征这些白质障碍, 以及治疗过程中的任何潜在连通性改善。在过去的五年中,我们申请了 自体脐带血(UCB)干细胞中小儿CP患者的高前分扩散MRI 疗法,并对自体UCB干细胞对影响和有益的理解有所了解 改善小儿CP患者的功能结果和大脑连通性。具体来说,我们发现了 相关的大脑网络中有很强的证据:1)大脑连接性障碍造成电动机 在治疗前基线时CP儿童的认知异常,2)大脑连通性增加 对UCB干细胞疗法期间的功能和行为改善有直接影响,3)大脑 连通性的提高超出了典型发展轨迹的连接性与干细胞有直接相关 剂量高于1.98 x 107单元​​/kg的潜在阈值,4)基线连通性的严重程度 异常预测进一步下降的风险和细胞疗法的益处。还发现 通过 使用定量敏感性映射(QSM)进行的其他初步研究。从此前进 坚实的基础,我们建议这种更新应用以进一步发展超高分辨率扩散MRI 和连接成像方法学以研究源自UCB的同种异体干细胞的积极作用 (存放在北卡罗来纳州脐带血库),这两者都可以达到必要的高剂量(相反 对有限的自体UCB干细胞),并应用于更多的CP患者(而不仅仅是患者 UCB出生时保存)。具体而言,我们建议:1)基于磁场的前所未有 关于我们最近的同时RF接收和BO Shimming Technology的创新,以使最高 可能的空间分辨率和忠诚度,2)使用多波段多弹性3D扩散MRI获取 超高亚毫米空间分辨率,优化的SNR和高吞吐量,以及3)获取和分析 超高分辨率扩散MRI和脑连接组图,以及DTI引导的髓磷脂敏感QSM 沿着白质途径和整个大脑连接组,在小儿CP患者中 使用UCB衍生的同种干细胞创新疗法的过程。预计我们继续 一致的努力将大大提高我们对两种连通性神经机制的理解 基线和干细胞疗法对连通性的影响的CP儿童的损害 修复,最终提供了令人信服的证据,以帮助计划最佳治疗方案。

项目成果

期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Column-based cortical depth analysis of the diffusion anisotropy and radiality in submillimeter whole-brain diffusion tensor imaging of the human cortical gray matter in vivo.
  • DOI:
    10.1016/j.neuroimage.2023.119993
  • 发表时间:
    2023-04-15
  • 期刊:
  • 影响因子:
    5.7
  • 作者:
    Ma, Yixin;Bruce, Iain P.;Yeh, Chun-Hung;Petrella, Jeffrey R.;Song, Allen W.;Truong, Trong-Kha
  • 通讯作者:
    Truong, Trong-Kha
Effect of Autologous Cord Blood Infusion on Motor Function and Brain Connectivity in Young Children with Cerebral Palsy: A Randomized, Placebo-Controlled Trial.
  • DOI:
    10.1002/sctm.17-0102
  • 发表时间:
    2017-12
  • 期刊:
  • 影响因子:
    6
  • 作者:
    Sun JM;Song AW;Case LE;Mikati MA;Gustafson KE;Simmons R;Goldstein R;Petry J;McLaughlin C;Waters-Pick B;Chen LW;Wease S;Blackwell B;Worley G;Troy J;Kurtzberg J
  • 通讯作者:
    Kurtzberg J
Simultaneous and inherent correction of B0 and eddy-current induced distortions in high-resolution diffusion MRI using reversed polarity gradients and multiplexed sensitivity encoding (RPG-MUSE).
使用反向极性梯度和多路复用灵敏度编码 (RPG-MUSE) 对高分辨率扩散 MRI 中的 B0 和涡流引起的畸变进行同步和固有校正。
  • DOI:
    10.1016/j.neuroimage.2018.09.055
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    5.7
  • 作者:
    Bruce,IainP;Petty,Christopher;Song,AllenW
  • 通讯作者:
    Song,AllenW
Recent Advances in Radio-Frequency Coil Technologies: Flexible, Wireless, and Integrated Coil Arrays.
  • DOI:
    10.1002/jmri.27865
  • 发表时间:
    2022-04
  • 期刊:
  • 影响因子:
    4.4
  • 作者:
    Darnell, Dean;Truong, Trong-Kha;Song, Allen W.
  • 通讯作者:
    Song, Allen W.
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

ALLEN W SONG其他文献

ALLEN W SONG的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('ALLEN W SONG', 18)}}的其他基金

A High-Performance 3T MRI Scanner for Brain Imaging
用于脑成像的高性能 3T MRI 扫描仪
  • 批准号:
    10175380
  • 财政年份:
    2021
  • 资助金额:
    $ 35.22万
  • 项目类别:
Biomarker Core
生物标志物核心
  • 批准号:
    10475321
  • 财政年份:
    2021
  • 资助金额:
    $ 35.22万
  • 项目类别:
Biomarker Core
生物标志物核心
  • 批准号:
    10263689
  • 财政年份:
    2021
  • 资助金额:
    $ 35.22万
  • 项目类别:
Biomarker Core
生物标志物核心
  • 批准号:
    10663999
  • 财政年份:
    2021
  • 资助金额:
    $ 35.22万
  • 项目类别:
A Compute Cluster for Brain Imaging and Analysis
用于脑成像和分析的计算集群
  • 批准号:
    9072820
  • 财政年份:
    2016
  • 资助金额:
    $ 35.22万
  • 项目类别:
Magnetic resonance imaging with inherent local shimming
具有固有局部匀场的磁共振成像
  • 批准号:
    8878559
  • 财政年份:
    2015
  • 资助金额:
    $ 35.22万
  • 项目类别:
Path Toward MRI with Direct Sensitivity to Neuro-Electro-Magnetic Oscillations
对神经电磁振荡具有直接敏感性的 MRI 之路
  • 批准号:
    8826908
  • 财政年份:
    2014
  • 资助金额:
    $ 35.22万
  • 项目类别:
Path Toward MRI with Direct Sensitivity to Neuro-Electro-Magnetic Oscillations
对神经电磁振荡具有直接敏感性的 MRI 之路
  • 批准号:
    9085395
  • 财政年份:
    2014
  • 资助金额:
    $ 35.22万
  • 项目类别:
Path Toward MRI with Direct Sensitivity to Neuro-Electro-Magnetic Oscillations
对神经电磁振荡具有直接敏感性的 MRI 之路
  • 批准号:
    8935948
  • 财政年份:
    2014
  • 资助金额:
    $ 35.22万
  • 项目类别:
High Fidelity Diffusion MRI for Children with Cerebral Palsy in Stem Cell Therapy
干细胞治疗中脑瘫儿童的高保真扩散 MRI
  • 批准号:
    8289889
  • 财政年份:
    2012
  • 资助金额:
    $ 35.22万
  • 项目类别:

相似国自然基金

基于先进算法和行为分析的江南传统村落微气候的评价方法、影响机理及优化策略研究
  • 批准号:
    52378011
  • 批准年份:
    2023
  • 资助金额:
    50 万元
  • 项目类别:
    面上项目
社交网络上观点动力学的重要影响因素与高效算法
  • 批准号:
    62372112
  • 批准年份:
    2023
  • 资助金额:
    50.00 万元
  • 项目类别:
    面上项目
员工算法规避行为的内涵结构、量表开发及多层次影响机制:基于大(小)数据研究方法整合视角
  • 批准号:
    72372021
  • 批准年份:
    2023
  • 资助金额:
    40 万元
  • 项目类别:
    面上项目
算法人力资源管理对员工算法应对行为和工作绩效的影响:基于员工认知与情感的路径研究
  • 批准号:
    72372070
  • 批准年份:
    2023
  • 资助金额:
    40 万元
  • 项目类别:
    面上项目
算法鸿沟影响因素与作用机制研究
  • 批准号:
    72304017
  • 批准年份:
    2023
  • 资助金额:
    30 万元
  • 项目类别:
    青年科学基金项目

相似海外基金

Fluency from Flesh to Filament: Collation, Representation, and Analysis of Multi-Scale Neuroimaging data to Characterize and Diagnose Alzheimer's Disease
从肉体到细丝的流畅性:多尺度神经影像数据的整理、表示和分析,以表征和诊断阿尔茨海默病
  • 批准号:
    10462257
  • 财政年份:
    2023
  • 资助金额:
    $ 35.22万
  • 项目类别:
Bioethical, Legal, and Anthropological Study of Technologies (BLAST)
技术的生物伦理、法律和人类学研究 (BLAST)
  • 批准号:
    10831226
  • 财政年份:
    2023
  • 资助金额:
    $ 35.22万
  • 项目类别:
Multi-modal Tracking of In Vivo Skeletal Structures and Implants
体内骨骼结构和植入物的多模式跟踪
  • 批准号:
    10839518
  • 财政年份:
    2023
  • 资助金额:
    $ 35.22万
  • 项目类别:
GPU-based SPECT Reconstruction Using Reverse Monte Carlo Simulations
使用反向蒙特卡罗模拟进行基于 GPU 的 SPECT 重建
  • 批准号:
    10740079
  • 财政年份:
    2023
  • 资助金额:
    $ 35.22万
  • 项目类别:
Extending Reach, Accuracy, and Therapeutic Capabilities: A Soft Robot for Peripheral Early-Stage Lung Cancer
扩大范围、准确性和治疗能力:用于周围早期肺癌的软机器人
  • 批准号:
    10637462
  • 财政年份:
    2023
  • 资助金额:
    $ 35.22万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了