Proprioceptive Coding of Jaw Movement during Orofacial Behavior

口面部行为过程中下颌运动的本体感受编码

基本信息

批准号：
9982691
负责人：
William Paul Olson
金额：
$ 7.03万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9982691
关键词：
Ablation Anatomy Animals Behavior Behavioral Breathing Cells Clinic Code Computational Technique Data Set Denture Wear Disease Eating Educational Status Environment Felis catus Food Genetic Golgi Tendon Organs Head Injections Jaw Knowledge Length Ligaments Mastication Mechanics Mechanoreceptors Modeling Molecular Monkeys Motion Motor Movement Movement Disorders Mus Muscle Muscle Spindles Neurons Neurosciences Oral cavity Output Pathologic Patients Pattern Physiological Physiology Play Process Property Proprioception Proprioceptor Resolution Role Sensory Skin Social Interaction Source Speed Sum System Target Populations Temporomandibular Joint Disorders Tendon structure Testing Tissues Tooth structure Toxin Tracer Training Trigeminal Nuclei Update Viral Virus Work awake base behavior test body position body sense disability drinking experimental study genetic manipulation hindbrain in vivo insight jaw movement molecular marker motor control mouse model neural circuit novel optogenetics orofacial relating to nervous system sensorimotor system sensory integration systems research tool treatment strategy

项目摘要

Project Summary Integration of sensory information with motor commands allows movement to be adaptable. For example, many survival-critical orofacial behaviors (chewing, drinking, breathing, etc.) involve updating movement trajectories based on interaction with objects (e.g. matching chewing patterns to food material properties). Proprioceptors, which are sensory afferents that provide information about body position, likely play critical roles in this process. However, given that most past recording of proprioceptors was not performed in awake animals, a clear understanding of proprioceptor movement coding in the awake context is lacking. This project will target and record from mouse jaw-innervating proprioceptors (which lie in the hindbrain mesencephalic trigeminal (MeV) nucleus) during orofacial behavior and test their functional role. Aim 1 will characterize the functional organization of mouse MeV afferents while developing genetic tools for targeting this population. Aim 2 will record from MeV neurons in behaving animals during high-resolution movement tracking. Using this dataset, a systematic quantitative model will be built for MeV neuron activity during voluntary orofacial behavior. Aim 3 will perturb MeV neuron activity to understand the functional role of MeV neurons in orofacial behavior. Completion of this project will involve high-level training in in vivo physiology, behavioral analysis, and systems/computational techniques. This training will draw upon a rich environment for neural circuit and systems research, especially based on the expertise in sensory and motor systems neuroscience in the labs of the Sponsor and Co-Sponsor. Collectively, the proposed project will define the information coding properties of proprioceptors during orofacial movement as well as probe the functional role of this information during behavior. These results could inform strategies for treatment of jaw motor problems seen in the clinic (i.e. denture-wearing patients, temporomandibular joint disorders, etc.). More broadly, this work can provide novel insights into the role of proprioceptive information in motor control, which has wide-ranging implications for the fundamental understanding of movement in healthy and pathological contexts.

项目概要感觉信息与运动命令的集成使得运动具有适应性。例如，许多对生存至关重要的口面部行为（咀嚼、饮水、呼吸等）都涉及更新运动基于与物体相互作用的轨迹（例如，将咀嚼模式与食物材料特性相匹配）。本体感受器是提供有关身体位置信息的感觉传入器，可能发挥着至关重要的作用在此过程中的角色。然而，考虑到过去大多数本体感受器的记录并不是在清醒的情况下进行的对于动物，在清醒情况下缺乏对本体感受器运动编码的清晰理解。这个项目将瞄准并记录小鼠下颌神经的本体感受器（位于后脑中脑）三叉神经（MeV）核）在口面部行为期间并测试其功能作用。目标 1 将描述小鼠 MeV 传入神经的功能组织，同时开发针对该群体的遗传工具。目的 2 将记录高分辨率运动跟踪期间动物行为的 MeV 神经元。使用这个数据集，将为自愿口面部期间的 MeV 神经元活动建立系统的定量模型行为。目标 3 将扰乱 MeV 神经元活动，以了解 MeV 神经元在口面部的功能作用行为。该项目的完成将涉及体内生理学、行为分析、和系统/计算技术。该培训将利用丰富的神经回路环境和系统研究，特别是基于实验室的感觉和运动系统神经科学专业知识赞助商和共同赞助商。总的来说，拟议的项目将定义信息编码属性口面部运动期间的本体感受器，以及探索该信息在口面部运动期间的功能作用行为。这些结果可以为临床上出现的下颌运动问题的治疗策略提供参考（即。戴假牙患者、颞下颌关节紊乱等）。更广泛地说，这项工作可以提供新颖的深入了解本体感觉信息在运动控制中的作用，这对运动控制具有广泛的影响对健康和病理情况下运动的基本理解。