Proprioceptive Coding of Jaw Movement during Orofacial Behavior

口面部行为过程中下颌运动的本体感受编码

• 批准号: 9982691
• 负责人: William Paul Olson
• 金额: $ 7.03万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9982691
• 关键词: Ablation; Anatomy; Animals; Behavior; Behavioral; Breathing; Cells; Clinic; Code; Computational Technique; Data Set; Denture Wear; Disease; Eating; Educational Status; Environment; Felis catus; Food; Genetic; Golgi Tendon Organs; Head; Injections; Jaw; Knowledge; Length; Ligaments; Mastication; Mechanics; Mechanoreceptors; Modeling; Molecular; Monkeys; Motion; Motor; Movement; Movement Disorders; Mus; Muscle; Muscle Spindles; Neurons; Neurosciences; Oral cavity; Output; Pathologic; Patients; Pattern; Physiological; Physiology; Play; Process; Property; Proprioception; Proprioceptor; Resolution; Role; Sensory; Skin; Social Interaction; Source; Speed; Sum; System; Target Populations; Temporomandibular Joint Disorders; Tendon structure; Testing; Tissues; Tooth structure; Toxin; Tracer; Training; Trigeminal Nuclei; Update; Viral; Virus; Work; awake; base; behavior test; body position; body sense; disability; drinking; experimental study; genetic manipulation; hindbrain; in vivo; insight; jaw movement; molecular marker; motor control; mouse model; neural circuit; novel; optogenetics; orofacial; relating to nervous system; sensorimotor system; sensory integration; systems research; tool; treatment strategy

Project Summary Integration of sensory information with motor commands allows movement to be adaptable. For example, many survival-critical orofacial behaviors (chewing, drinking, breathing, etc.) involve updating movement trajectories based on interaction with objects (e.g. matching chewing patterns to food material properties). Proprioceptors, which are sensory afferents that provide information about body position, likely play critical roles in this process. However, given that most past recording of proprioceptors was not performed in awake animals, a clear understanding of proprioceptor movement coding in the awake context is lacking. This project will target and record from mouse jaw-innervating proprioceptors (which lie in the hindbrain mesencephalic trigeminal (MeV) nucleus) during orofacial behavior and test their functional role. Aim 1 will characterize the functional organization of mouse MeV afferents while developing genetic tools for targeting this population. Aim 2 will record from MeV neurons in behaving animals during high-resolution movement tracking. Using this dataset, a systematic quantitative model will be built for MeV neuron activity during voluntary orofacial behavior. Aim 3 will perturb MeV neuron activity to understand the functional role of MeV neurons in orofacial behavior. Completion of this project will involve high-level training in in vivo physiology, behavioral analysis, and systems/computational techniques. This training will draw upon a rich environment for neural circuit and systems research, especially based on the expertise in sensory and motor systems neuroscience in the labs of the Sponsor and Co-Sponsor. Collectively, the proposed project will define the information coding properties of proprioceptors during orofacial movement as well as probe the functional role of this information during behavior. These results could inform strategies for treatment of jaw motor problems seen in the clinic (i.e. denture-wearing patients, temporomandibular joint disorders, etc.). More broadly, this work can provide novel insights into the role of proprioceptive information in motor control, which has wide-ranging implications for the fundamental understanding of movement in healthy and pathological contexts.

项目摘要 感官信息与电机命令的集成使运动具有适应性。例如， 许多至关重要的口面行为（咀嚼，饮酒，呼吸等）涉及更新运动 基于与物体相互作用的轨迹（例如，将咀嚼模式匹配到食物材料特性）。 本体感受器是提供有关身体位置信息的感官传入，可能会发挥关键作用 在此过程中的角色。但是，鉴于大多数过去的本体受体录音都没有在清醒中进行 动物，对在清醒环境中的本体感受器移动编码的清晰理解缺乏。这个项目 将靶向和记录鼠​​标下巴发动的本体感受器（位于后脑脑脑中 在口面上行为并测试其功能作用的三叉神经（MEV）核）。 AIM 1将表征 小鼠MEV传入的功能组织在开发用于目标人群的遗传工具时。目的 在高分辨率运动跟踪过程中，将从MEV神经元中记录MEV神经元的行为动物。使用此 数据集，将在自愿性口面期间为MEV神经元活动建立系统的定量模型 行为。 AIM 3将扰动MEV神经元活动，以了解MEV神经元在Orofacial中的功能作用 行为。该项目的完成将涉及体内生理学，行为分析的高级培训， 和系统/计算技术。该培训将借鉴神经回路的丰富环境， 系统研究，尤其是基于感官和运动系统神经科学领域的专业知识 赞助商和共同发起人。拟议的项目共同定义了信息编码属性 口面运动期间的本体受体以及探测此信息在此期间的功能作用 行为。这些结果可以为治疗诊所中的下颌运动问题的策略提供信息（即 穿着义齿的患者，颞下颌关节疾病等）。更广泛地，这项工作可以提供小说 对本体感受信息在运动控制中的作用的见解，这对运动具有广泛的影响 对健康和病理环境中运动的基本理解。