Blood metabolite profiles and risk of developing endometrial cancer
血液代谢特征和患子宫内膜癌的风险
基本信息
- 批准号:9982059
- 负责人:
- 金额:$ 24.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-05-09 至 2022-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAlcoholsAncillary StudyAttenuatedBackBeveragesBig DataBiologicalBiological MarkersBloodBlood specimenBody mass indexBreast Cancer PreventionCancer EtiologyCancer Prevention InterventionCancer Prevention Study IICause of DeathClinicalCoffeeColorectal CancerCommunitiesConflict (Psychology)ConsumptionDataDevelopmentDiagnosisDiagnosticDietDietary AssessmentDietary FactorsDietary FatsDietary QuestionnairesDietary intakeDiseaseEmerging TechnologiesEndometrialEndometrial CarcinomaEpidemiologyEstrogen receptor negativeEstrogen receptor positiveEtiologyFailureFastingFemaleFoodFruitFutureGoalsGoldHourHumanIncidenceIndividualLaboratoriesLinkMalignant Female Reproductive System NeoplasmMalignant NeoplasmsMalignant neoplasm of lungMalignant neoplasm of ovaryMalignant neoplasm of prostateMeasurementMeasuresMediationMeta-AnalysisMetabolicMetabolic PathwayMetabolismMethodsMolecular EpidemiologyNested Case-Control StudyNurses&apos Health StudyObesityOutcomeOverweightPathway interactionsPatient Self-ReportPhasePostmenopauseProspective StudiesProspective cohortProstate, Lung, Colorectal, and Ovarian Cancer Screening TrialPublic HealthQuestionnairesResearchResourcesRiskRisk FactorsRoleSerumSignal TransductionStatistical Data InterpretationSuggestionTimeTumor SubtypeUnited StatesUrineWomanWomen&aposs HealthWorkbasecancer preventioncancer riskcancer subtypescandidate markercase controlcohortdiet and cancerdietary supplementsendometrial cancer preventionevidence basefeedingfood consumptionimprovedinsightinterestmalignant breast neoplasmmetabolomemetabolomicsmodifiable riskmortalitynew technologynovelprospectiverare cancerrisk prediction modelstandard measuretooltumor heterogeneity
项目摘要
PROJECT SUMMARY
Cancer is a leading cause of death in the United States, with a third of diagnoses attributed to modifiable risk
factors including obesity and poor diet. Understanding the role of these risk factors in cancer development is
crucial for the provision of appropriate public health guidance for cancer prevention.
Breast cancer remains the highest incidence cancer among women in the United States, and incidence rates
for endometrial cancer are projected to dramatically increase over the next decade. Epidemiological, clinical
and laboratory evidence suggests that diet may be relevant for breast and endometrial cancer prevention,
although the evidence base lacks consistency, perhaps owing to imprecise dietary measures, and a failure to
account for associations that may vary by tumor subtype. Furthermore, endometrial cancer is especially
obesity-driven, but the underlying mechanisms have yet to be fully characterized.
There is a need for better objective measures of diet, including dietary biomarkers, that can be used to improve
dietary assessment. Metabolomics is a novel and emerging technology in molecular epidemiology that can be
used to measure hundreds to thousands of circulating metabolites simultaneously, more than 200 of which
have been recently linked to an individual’s diet and/or adiposity. Furthermore, metabolomics can be used to
highlight biological mechanisms of interest in relation to disease. This novel technology is advancing rapidly,
and much work is yet to be done in applying it in an epidemiologic context.
To address this unmet need, I propose to apply metabolomics to understanding the relationships of diet and
adiposity with female cancers. I will first quantify the relationship between circulating metabolites and habitually
consumed foods in a feeding study with a gold-standard measure of diet (weighed food) among
postmenopausal women in order to develop objective dietary biomarkers. Such work is critical for correct
interpretation of any diet-related metabolite signals that may be observed in subsequent cancer studies. Next, I
will measure the association between pre-diagnostic circulating diet-related metabolites and estrogen receptor-
negative (ER-) breast cancer using nested case-control data from three prospective cohorts. ER- breast cancer
is rare, aggressive and understudied. Consequently, the etiology is poorly understood, including potential
dietary risk factors. Finally, I will determine whether pre-diagnostic circulating metabolites are associated with
incident endometrial cancer, and their relation to diet or adiposity using nested case-control data from four
prospective cohorts. No studies have explored metabolite signatures of endometrial cancer and their relation to
adiposity and diet using data from US-based prospective studies. These studies may uncover unknown
metabolic pathways involved in the etiology of breast and endometrial cancer that may also be applicable to
other obesity-driven cancers, and identify key pathways for developing and evaluating targeted cancer
prevention interventions.
项目摘要
癌症是美国的主要死亡原因,其中三分之一的诊断归因
包括肥胖和饮食不佳的因素。
对于为预防癌症提供适当的公共卫生指导至关重要。
乳腺癌仍然是美国女性中最高的癌症,发病率是
对于子宫内膜癌,在未来十年中会急剧增加。
实验室证据表明,饮食可能与乳腺癌和子宫内膜癌的预防有关,
大小
可能因肿瘤亚型而变化的关联。
肥胖驱动的,但潜在的机制尚未充分表征。
需要更好的客观饮食措施
饮食评估。
用于同时测量数百至数千个循环代谢物,其中200多个
最近与个人的饮食和 /或肥胖有关。
突出了与疾病有关的生物学机制。
而且很多工作尚未
为了满足这种未满足的需求,我建议将代谢组学应用于了解饮食的关系和
与女性癌的脂肪症首先量化循环代谢
在一项喂食研究中,食用食物,并在饮食中获得金色标准的饮食(加权食物)
绝经后妇女为了发展客观的饮食生物标志物。
对任何与饮食相关的代谢物信号的解释,这些信号可能被取消取消
将衡量诊断前循环饮食相关代谢产物与雌激素受体之间的关联
使用前瞻性队列的嵌套病例对照数据阴性(ER-)乳腺癌。
我很罕见,侵略性和研究。
饮食危险因素。
事件子宫内膜癌,及其与四个病例对照数据的饮食或脂肪症关系
前瞻性人群。
使用基于美国的前瞻性研究数据的dipuse和饮食可能会发现未知的
参与乳腺癌和子宫内膜癌症病因的代谢途径也可能适用
其他肥胖驱动的癌症,并确定针对癌症的开发和评估的关键途径
预防间隔。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Measuring Dietary Botanical Diversity as a Proxy for Phytochemical Exposure.
- DOI:10.3390/nu13041295
- 发表时间:2021-04-14
- 期刊:
- 影响因子:5.9
- 作者:Thompson HJ;Levitt JO;McGinley JN;Chandler P;Guenther PM;Huybrechts I;Playdon MC
- 通讯作者:Playdon MC
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Mary Christine Playdon其他文献
Mary Christine Playdon的其他文献
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{{ truncateString('Mary Christine Playdon', 18)}}的其他基金
Ceramides as novel drivers of metabolic dysfunction and colorectal cancer
神经酰胺作为代谢功能障碍和结直肠癌的新驱动因素
- 批准号:
10696086 - 财政年份:2022
- 资助金额:
$ 24.9万 - 项目类别:
Ceramides as novel drivers of metabolic dysfunction and colorectal cancer
神经酰胺作为代谢功能障碍和结直肠癌的新驱动因素
- 批准号:
10505169 - 财政年份:2022
- 资助金额:
$ 24.9万 - 项目类别:
Global metabolomics profiling, dietary factors, and colorectal cancer risk in the NIH-Consortium of Metabolomics Studies (COMETS)
NIH 代谢组学研究联盟 (COMETS) 中的全球代谢组学分析、饮食因素和结直肠癌风险
- 批准号:
10645028 - 财政年份:2022
- 资助金额:
$ 24.9万 - 项目类别:
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