Rutgers Center for Environmental Exposure and Disease (CEED)

罗格斯大学环境暴露与疾病中心 (CEED)

• 批准号: 9927635
• 负责人: HELMUT ZARBL
• 金额: $ 202.61万
• 依托单位: RBHS-SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9927635
• 关键词: Address; Affect; Age; Area; Behavior; Bioinformatics; Biological; Biological Markers; Biology; Center for Translational Science Activities; Clinical; Clinical Research; Collaborations; Communities; Community Health; Community Participation; Complex; Core Facility; Cost-Benefit Analysis; Data; Development; Diet; Disease; Educational Curriculum; Environment; Environmental Exposure; Environmental Health; Environmental Impact; Epidemiology; Epigenetic Process; Exposure to; Faculty; Federal Government; Fostering; Funding; Genetic; Genomics; Goals; Government Agencies; Grant; Health; Health Policy; Human; Individual; Industry; Informatics; Intervention; K-Series Research Career Programs; Labor Unions; Link; Local Government; Mentors; Metagenomics; Mission; Modeling; National Institute of Environmental Health Sciences; Pathogenesis; Pilot Projects; Policies; Population; Prevention strategy; Preventive Intervention; Psychosocial Factor; Psychosocial Stress; Public Health; Regulation; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Risk; Science; Scientist; State Government; Statutes and Laws; Structure; System; Teacher Professional Development; Technology; Toxic Environmental Substances; Toxicology; Training; Training Support; Translating; Universities; Ursidae Family; Vision; Vulnerable Populations; Work; base; cofactor; comorbidity; cost effective; data integration; data streams; design; disorder prevention; empowered; environmental justice; environmental stressor; evidence base; faculty support; health disparity; improved; innovation; interest; investigator training; member; metabolomics; microbiome analysis; microbiome research; new technology; population based; programs; psychosocial; recruit; response; risk mitigation; sex; social stressor; social structure; stressor; tool; toxicant; treatment strategy

OVERALL: ABSTRACT The theme of the Rutgers Center for Environmental Exposures and Disease (CEED) is Precision Environmental Health (PEH) research, which we define as the integration of data from exposure biology, genomics, epigenetics, and microbiomics to identify biological responses that are mechanistically linked to pathogenesis and that will inform disease prevention. The mission of CEED is to improve health and diminish the impact of environmental toxicants and stressors by reducing exposures and mitigating their adverse biological effects. Our vision is that a PEH research approach can better inform the development of precise and targeted prevention/intervention strategies. Our strategy is to recruit and train investigators who can integrate information-rich data streams from new technologies with the Center’s longstanding expertise in clinical, basic, population-based, and community engaged research to reduce the burden of environmental disease, especially in vulnerable and environmental justice communities, which bear the greatest burden of exposures and health disparities. To achieve our strategic vision, CEED is formed as a hub of transdisciplinary research, combining access to cutting-edge technologies and computational approaches with a team of outstanding scientists with expertise in exposure science, mechanistic toxicology, modeling and bioinformatics, human research, epidemiology, and community engagement. CEED aims to reduce adverse health effects of toxicants and stressors through transdisciplinary PEH research that considers all aspects of the individual’s responsiveness that contribute to disease pathogenesis and that uses this information to design mechanistically-guided intervention and prevention strategies. We aim to engage communities and stakeholders in multidirectional interactions and participatory research to: 1) identify exposures that are of concern to communities and have the potential to adversely affect human health; 2) assess and model the extent of exposures in affected populations; 3) identify cofactors (i.e., psychosocial factors, age, sex, genetics, co-morbidity, etc.) and assess their impact on individual responsiveness to toxicants; 4) discover and use biological response indicators that link exposures to mechanisms of disease pathogenesis; 5) develop and implement mechanistically-driven prevention, intervention, and treatment strategies; 6) reduce exposures and mitigate health effects by informing systems changes that alter behaviors, practices, policies and regulations.

总体：摘要 罗格斯环境暴露与疾病中心（CEED）的主题精确 环境健康（PEH）研究，我们将其定义为暴露生物学数据的整合， 基因组学，表观遗传学和微生物学以识别机械上的生物学反应 与发病机理有关，这将为疾病预防提供依据。 CEED的任务是改善健康 并通过减少暴露并减轻环境毒物和压力源的影响并减轻其影响 不良生物学效应。我们的愿景是PEH研究方法可以更好地告知 精度和有针对性的预防/干预策略。我们的策略是招募和培训调查员 可以将新技术的信息丰富的数据流与中心的长期专业知识整合在一起 临床，基础，基于人群和社区参与研究以减少环境的燃烧 疾病，尤其是在脆弱和环境正义社区中，这是最大的伯恩。 暴露和健康差异。为了实现我们的战略愿景，CEED被形成为跨学科的枢纽 研究，将对先进技术和计算方法的访问结合在一起 具有曝光科学，机械毒理学，建模和生物信息学专业知识的杰出科学家， 人类研究，流行病学和社区参与。 CEED旨在减少对健康的不利影响 通过跨学科的PEH研究考虑了个人的各个方面，有毒物质和压力源 有助于疾病发病机理并使用此信息设计的反应能力 机械引导的干预和预防策略。我们旨在吸引社区和 多方向互动和参与研究的利益相关者至：1）确定的暴露 关注社区，并有可能对人类健康产生不利影响； 2）评估和建模 受影响人群的暴露程度； 3）识别辅助因子（即心理社会因素，年龄，性别，遗传学， 合并症等）并评估其对毒物的个人反应性的影响； 4）发现和使用 生物反应指标将暴露与疾病发病机理的机理联系起来； 5）发展和 实施机械驱动的预防，干预和治疗策略； 6）减少暴露和 通过告知系统变化，以改变行为，实践，政策和法规，来减轻健康的影响。