Inflammatory Mechanisms Linking Sleep Disturbances and Cognitive Deficits in Schizophrenia in Later Life

与精神分裂症晚年睡眠障碍和认知缺陷相关的炎症机制

• 批准号: 9926924
• 负责人: Ellen Eun-Ok Lee
• 金额: $ 20.26万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-07 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9926924
• 关键词: Accounting; Address; Affect; Age; Aging; Antipsychotic Agents; Attention; Behavior; Bioinformatics; Biological; Body mass index; C-reactive protein; Cell Count; Cells; Chronic; Chronic Disease; Clinical; Cognition; Cognitive; Cognitive deficits; Complex; Consensus; Data; Development; Diet; Dimensions; Dose; Elderly; Expression Profiling; Future; Gene Expression; Gene Expression Profiling; General Population; Genomics; Goals; Immune; Impaired cognition; Incidence; Individual; Inflammation; Inflammatory; Interleukin-6; Intervention; Investigation; K-Series Research Career Programs; Lead; Link; Longitudinal Studies; Measures; Mediating; Mediator of activation protein; Mental Depression; Mental disorders; Modeling; National Institute of Mental Health; Pathway interactions; Patient Self-Report; Performance; Persons; Physical activity; Pittsburgh Sleep Quality Index; Reporting; Research; Risk Factors; Sample Size; Schizophrenia; Scientist; Severities; Sleep; Sleep Disorders; Sleep disturbances; Sleeplessness; Smoking; Testing; Time; Training; United States National Institutes of Health; Vulnerable Populations; Woman; actigraphy; age related; base; career; cognitive function; cognitive performance; cost; executive function; follow-up; geriatric mental health; high risk; improved; improved functioning; indexing; inflammatory marker; lifestyle factors; men; middle age; modifiable risk; molecular marker; promoter; recruit; sex; skills; sleep quality; transcription factor; translational physician

SUMMARY/ABSTRACT The proposed K23 application will strongly support Ellen Lee, MD’s long-term career goal of becoming an independent clinical-translational physician-scientist in geriatric mental health. This project investigates inflammatory mechanisms underlying sleep and cognition in middle-aged and older adults (41-70 years old) with schizophrenia (SZ). The proposal has considerable

摘要/摘要 拟议的K23应用程序将强烈支持医学博士艾伦·李（Ellen Lee）的长期职业目标艾伦·李（Ellen Lee），即成为老年人心理健康中独立的临床转变体科学家。该项目通过精神分裂症（SZ）调查了中年和老年人（41 - 70岁）的睡眠和认知的炎症机制。该提议考虑了